Improvement in Large Density HDL Particle Number by NMR Is Associated With Improvement in Vascular Inflammation by 18-FDG Pet/Ct at One-Year in Psoriasis

Dey, Amit; Playford, Martin P.; Joshi, Aditya; Belur, Agastya D.; Goyal, Aditya; Elnabawi, Youssef; Groenendyk, Jacob; Chung, Jonathan; Rivers, Joshua; Rodante, Justin; Genovese, Leonard; Sajja, Aparna; Jain, Tushina; Harrington, Charlotte; Varghese, Nevin; Shukla, Parag; Teague, Heather; Baumer, Yvonne; Remaley, Alan T.; Ahlman, Mark A.; Gelfand, Joel; Mehta, Nehal N.

doi:10.1016/s0735-1097(18)32229-0

Cited by 3 publications

(4 citation statements)

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“…A pilot research [4] and a cross-sectional study [18] used the same data set, and we chose the former to analyze the overlapped data. Thus, eleven individual articles [4, 7–13, 19–21] with 12 studies satisfying inclusion criteria were identified in the systematic review, and study characteristics were reported in Table 1. Cases, controls and outcomes of each study were carefully extracted and inspected.…”

Section: Resultsmentioning

confidence: 99%

“…Recent studies [4, 14, 21] indicate that the anti-tuberculosis effect of metformin is dependent on the standard regimen for TB, and metformin only acts as a supporting role with long-term medication. Two studies [11, 21] suggest that metformin usage could not reduce the sputum culture conversion in patients with DM. We consider the small sample size substantially reduce the statistical power, and the deficiency has been solved by the meta-analysis (see Fig.…”

Section: Discussionmentioning

confidence: 99%

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Impact of metformin on the risk and treatment outcomes of tuberculosis in diabetics: a systematic review

Xia

et al. 2019

BMC Infect Dis

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Background Tuberculosis (TB) remains one of the infectious diseases with a leading cause of death among adults worldwide. Metformin, a first-line medication for the treatment of type 2 diabetes, may have potential for treating TB. The aims of the present systematic review were to evaluate the impact of metformin prescription on the risk of tuberculosis diseases, the risk of latent TB infection (LTBI) and treatment outcomes of tuberculosis among patients with diabetic mellitus. Methods Databases were searched through March 2019. Observational studies reporting the effect of metformin prescription on the risk and treatment outcomes of TB were included in the systematic review. We qualitatively analyzed results of included studies, and then pooled estimate effects with 95% confidence intervals (CIs) of different outcome using random-effect meta-analyses. Results This systematic review included 6980 cases from 12 observational studies. The meta-analysis suggested that metformin prescription could decrease the risk of TB among diabetics (pooled odds ratio [OR], 0.38; 95%CI, 0.21 to 0.66). Metformin prescription was not related to a lower risk of LTBI (OR, 0.73; 95%CI, 0.30 to 1.79) in patients with diabetes. Metformin medication during the anti-tuberculosis treatment is significantly associated with a smaller TB mortality (OR, 0.47; 95%CI, 0.27 to 0.83), and a higher probability of sputum culture conversion at 2 months of TB disease (OR, 2.72; 95%CI, 1.11 to 6.69) among patients with diabetes. The relapse of TB was not statistically reduced by metformin prescription (OR, 0.55; 95%CI, 0.04 to 8.25) in diabetics. Conclusions According to current observational evidence, metformin prescription significantly reduced the risk of TB in patients with diabetes mellitus. Treatment outcomes of TB disease could also be improved by the metformin medication among diabetics.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact of metformin on the risk and treatment outcomes of tuberculosis in diabetics: a systematic review

Xia

et al. 2019

BMC Infect Dis

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“…Evidence shows that wheat yields in Australia have already stalled because of the changing climate. 5 Furthermore, CO 2 greater than 450 parts per million is likely to have a negative effect on grain quality. 6 A more complete analysis of the effects of climate change on health is provided by the Intergovernmental Panel on Climate Change (IPCC)-overall, they are expected to be overwhelmingly negative.…”

Section: Authors' Replymentioning

confidence: 99%

Health and climate change – Authors' reply

et al. 2019

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“…3,4 Further more, the high sensitivity of these approaches will allow assessment of response to therapeutic interventions shortly after initiation, which might not be feasible with conventional imaging techniques. 5 Structural changes are well established to remain unchanged for an extended period of time and, therefore, might not allow timely adoption of the most effective therapeutic inter vention. We strongly believe that future imaging techniques should include both PET and structural imaging methods, such as CT and MRI, in combination for optimal manage ment of many disorders, including atherosclerosis.…”

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confidence: 99%