Improvement in Pharmacokinetic Parameters of Ibuprofen by Crystal Engineering Approach

Vaghela, Parth; Tank, H. M.

doi:10.35652/igjps.2020.10103

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…This technology is the most popular because it uses a quick, continuous, and one-step process. As a result, the spray drying process will present a distinctive setting for the creation and expansion of co-crystals [60,61].…”

Section: Spray Drying Techniquementioning

confidence: 99%

Modification of Physicochemical Properties of Active Pharmaceutical Ingredient by Pharmaceutical Co-Crystals

Thenge¹,

Adhao²,

Mehetre³

et al. 2023

Drug Formulation Design

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The oral drug delivery is widely used and accepted routes of administration, but it fails to provide the therapeutic effectiveness of drugs due to low solubility, poor compression and oral bioavailability. Crystal engineering is the branch where the modification of API is of great importance. Co-crystallization of API using a co-former is a hopeful and emerging approach to improve the performance of pharmaceuticals, such as micromeritic properties, solubility, dissolution profile, pharmacokinetics and stability. Pharmaceutical co-crystals are multicomponent systems in which one component is an active pharmaceutical ingredient and the others are pharmaceutically acceptable ingredients that are of GRAS category. In multidrug co-crystals one drug acts as API and other drug acts as coformer. This chapter illustrates the guidance for more efficient design and manufacture of pharmaceutical co-crystals with the desired physicochemical properties and applications.

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Section: Spray Drying Techniquementioning

confidence: 99%

Modification of Physicochemical Properties of Active Pharmaceutical Ingredient by Pharmaceutical Co-Crystals

Thenge¹,

Adhao²,

Mehetre³

et al. 2023

Drug Formulation Design

View full text Add to dashboard Cite

show abstract

“…Improvement in the mechanical and processing parameters like flowability, packability, compactibility, and compressibility of samples under investigation enables to employ direct compression process of Ibuprofen crystals prepared by crystallization technique [5]. Hence tablets containing the pure drug, its control batch and an equivalent amount of Ibuprofen containing treated crystals are prepared by direct compression process by using different formulation excipients.…”

Section: Directly Compressible Tablets Of Pure Drug Its Control Batch...mentioning

confidence: 99%

Preparation and Evaluation of Directly Compressible Tablets of Ibuprofen Crystals

Vaghela¹,

Patel²,

Tank³

2022

IGJPS

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The goalof present studywas to prepare the directly compressible tablets of Ibuprofen crystals prepared by crystallization technique using saccharin sodium as an excipient. The prepared tabletswere evaluatedfor the improvement in drug release of Ibuprofenas compared to the pure drug. The crystal formation of Ibuprofen lead to improve the compressibility and mechanical strength of thedrug which can be easily converted to directlycompressible tablets. The In-vitro dissolution profiledemonstrates 3.96fold incrementin the drug release rate from tablets of Ibuprofen crystals compared to the pure drug after one hour. The characterization was done byPowder X-Ray Diffractometry (pXRD), and Headspace Gas Chromatography (HSGC) Study of Ibuprofen treated crystals illustrates the improvement in manufacturabilityand pharmacotechnical parameters of the drug.©2022iGlobal Research and PublishingFoundation. All rights reserved.

show abstract

Improvement in Pharmacokinetic Parameters of Ibuprofen by Crystal Engineering Approach

Cited by 2 publications

References 9 publications

Modification of Physicochemical Properties of Active Pharmaceutical Ingredient by Pharmaceutical Co-Crystals

Modification of Physicochemical Properties of Active Pharmaceutical Ingredient by Pharmaceutical Co-Crystals

Preparation and Evaluation of Directly Compressible Tablets of Ibuprofen Crystals

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