2001
DOI: 10.1159/000050495
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Improvement in Right Lung Atelectasis (Middle Lobe Syndrome) following Administration of Low-Dose Roxithromycin

Abstract: Middle lobe syndrome is a distinct clinical entity characterized by right middle lobe atelectasis. Prompt diagnosis and initiation of medical therapy including the administration of antibiotics and the avoidance of irritating agents may be effective. However, abnormal shadows on chest radiography remain unchanged even when acute symptoms have disappeared, suggesting latent lesional inflammation or recurrence. We describe 2 cases of atelectasis in the middle lobe of the right lung which resolved completely afte… Show more

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Cited by 7 publications
(4 citation statements)
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“…Otherwise, broad-spectrum antibiotics are used, covering streptococci (including Streptococcus pneumoniae ), Haemophilus influenzae, Moraxella catarrhalis and even Pseudomonas aeruginosa in difficult cases [3]. Low-dose macrolide therapy can be used, particularly if bronchiectasis is present [35]. Consideration must also be given to unusual infections (atypical mycobacteria, fungi) that may require specific antimicrobial agents [11,12,14].…”
Section: Treatment and Prognosis Of Mlsmentioning
confidence: 99%
“…Otherwise, broad-spectrum antibiotics are used, covering streptococci (including Streptococcus pneumoniae ), Haemophilus influenzae, Moraxella catarrhalis and even Pseudomonas aeruginosa in difficult cases [3]. Low-dose macrolide therapy can be used, particularly if bronchiectasis is present [35]. Consideration must also be given to unusual infections (atypical mycobacteria, fungi) that may require specific antimicrobial agents [11,12,14].…”
Section: Treatment and Prognosis Of Mlsmentioning
confidence: 99%
“…Sometimes, broncholiths and foreign objects can be removed with flexible fiber‐optic or rigid bronchoscopy. Patients with the nonobstructive form usually respond to medical therapy that includes bronchodilators, antibiotics and mucolytic agents (2, 3, 8). If conservative treatment fails and symptoms persist with chronic atelectasis on chest radiograph, surgical removal is an option.…”
Section: Introductionmentioning
confidence: 99%
“…4,7 Long-term low-dose macrolide therapy has been shown to result in complete resolution of symptoms of MLS in selected patients. 24 Macrolides are thought to be efficacious in the treatment of MLS via their ability to reduce surface expression of the MAC-1 molecule on neutrophils, 25 to suppress active oxygen generation, 26 to improve mucociliary clearance, 27 to decrease mucus hypersecretion, 28 and to promote anti-inflammatory activity. 29 The use of bronchodilators, in combination with inhaled or oral corticosteroids, may be particularly useful in patients with MLS-associated asthma.…”
Section: Treatment Of Mlsmentioning
confidence: 99%