Improvement of Arthritic Signs in Dogs Fed Green-Lipped Mussel (Perna canaliculus)

Bierer, Tiffany L.; Bui, Linh M.

doi:10.1093/jn/132.6.1634s

Cited by 57 publications

(53 citation statements)

References 2 publications

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“…Green-lipped mussel is known to have anti-inflammatory properties with active ingredients including the presence of eicosatetraenoiec acid and a blend of other unique fatty acids (Bierer and Bui, 2002;Bui et al, 2003;Hielm-Bjorkman et al, 2009;Servet et al, 2006). It can be incorporated into food through a freeze-dried powder or as an oil extract (Pollard et al, 2006).…”

Section: Green-lipped Musselmentioning

confidence: 99%

“…One group of researchers conducted a series of 3 clinical studies on dogs (age range: 4 to 13 years; n = 31 to 33/study) with signs of arthritis and evaluated the effects of GLM as a powdered supplement fed on top of a control diet (< 25 kg BW = 450 mg GLM/day; 25 to 34 kg BW = 750 mg GLM/day; > 34 kg BW = 1000 mg GLM/day), or incorporated into a treat or dry main meal diet for a period of 6 weeks (Bierer and Bui, 2002). A veterinarian scored each dog for lameness when walking, trotting, and climbing stairs, resulting in a "visual score".…”

Section: Green-lipped Musselmentioning

confidence: 99%

“…Those two scores then were averaged to give a "total arthritic score" (TAS). For all three studies, total arthritic score, joint pain, and joint swelling were reduced (P < 0.05) in the GLM treated groups compared to the control (Bierer and Bui, 2002). A multicenter study was conducted over 50 days on OA-stricken dogs (n = 85) evaluating the effects of GLM incorporated into an extruded diet at a dose of 0.3% (Servet et al, 2006).…”

Section: Green-lipped Musselmentioning

confidence: 99%

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Effects of dietary calcium fructoborate supplementation on joint comfort and flexibility and serum inflammatory markers in dogs with osteoarthritis

Price¹,

Godoy²,

Harper³

et al. 2017

Journal of Animal Science

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Symptoms of osteoarthritis (OA) afflict approximately 20% of adult dogs in NorthAmerica. Clinical signs consistent with OA include decreased range of motion of a joint, reduced physical activity, difficulty climbing stairs or onto furniture, and a reduced ability to rise from a lying position. A safe and effective nutraceutical supplement may benefit dogs suffering from OA. Calcium fructoborate (CFB), a mimetic of a naturally occurring molecule, has previously been reported to be safe and effective in humans with joint problems. The objective of this randomized, double-blinded, placebo-controlled study was to evaluate the short-term effects of CFB alone, or in combination with a blend of glucosamine hydrochloride (GH) and chondroitin sulfate (CS), on gait analysis, goniometry, serum inflammatory markers, and owner perception of pain in client-owned dogs. Sixty-four dogs with joint discomfort were recruited and 59 dogs (mean age = 8.42 ± 0.37 yr.; mean BW = 31.11 ± 1.28 kg) completed the study. All procedures were approved by the University of Illinois Institutional Animal Care and Use Committee, and pet owners signed an informed consent prior to study initiation. Dogs were randomly assigned to one of four treatments: placebo (60 mg fructose; n = 15), low dose (69 mg CFB; n = 14), high dose (127 mg CFB; n = 14), or combination (69 mg CFB, 500 mg GH and 200 mg CS; n = 16).Treatments were provided once daily as dietary supplements. Small dogs weighing up to 22.9 kg received 1 capsule/day, while large dogs weighing 23 to 50 kg received 2 capsules/day for 28 days. A physical examination, radiographs, goniometry measurements, gait analysis, blood sample collection, and the canine brief pain inventory (CBPI) questionnaire were performed and administered on days 0 and 28. As expected, a majority (69%) of the dogs were overweight or obese, with a body condition score (BCS) > 6 on a 9-point scale. Dogs fed the low dose (-2.93) and high dose (-2.21) of CFB were shown to improve (P < 0.05) in their ability to rise from a iii lying position from day 0 to day 28 compared to dogs fed the placebo (0.00), but no difference was observed for dogs fed the combination treatment. Dogs assigned the low dose of CFB also tended to have an improved pain severity score (PSS; -1.46; P = 0.08) and pain at its worst score (-2.14; P = 0.06) from day 0 to day 28 compared to dogs fed the placebo (0.05 and 0.00, respectively). Dogs fed the high dose of CFB had a greater increase (P = 0.05) in serum concentration of soluble receptor for advanced glycation end products (sRAGE) from day 0 to day 28 (7.88 ng/mL) compared to dogs fed the placebo (0.83 ng/mL). All blood metabolites were within reference range except total alkaline phosphatase and corticosteroid-induced alkaline phosphatase, which started and ended at concentrations greater than the upper reference range.Dogs assigned the high dose of CFB tended to have a greater reduction (P = 0.07) in serum chloride from day 0 to day 28 (-1.64 mmol/L) compared to dogs fed the low dose of ...

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Section: Green-lipped Musselmentioning

confidence: 99%

Section: Green-lipped Musselmentioning

confidence: 99%

Section: Green-lipped Musselmentioning

confidence: 99%

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Effects of dietary calcium fructoborate supplementation on joint comfort and flexibility and serum inflammatory markers in dogs with osteoarthritis

Price¹,

Godoy²,

Harper³

et al. 2017

Journal of Animal Science

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show abstract

“…Um grande problema é que o processamento térmico dos GLM pode destruir a sua capacidade terapêutica, desta forma o processamento do GLM e a incorporação em produtos alimentares requerem técnicas especiais de processamento, pois se não houver cuidados pode ocorrer à perda da eficácia do produto final, devendo haver processamento com baixa temperatura (Bierer & Bui, 2002).…”

Section: Glm (Green-lipped Mussels)unclassified

“…Estudos realizados por Bierer & Bui (2002) demonstraram que o GLM em pó é eficaz na redução dos sinais de artrose em cães, tanto quando incorporados na ração ou aspergidos sobre a dieta. Os escores totais da artrite nas pontuações de dor e inchaço foram reduzidos significativamente após 6 semanas de suplementação com o GLM.…”

Section: Glm (Green-lipped Mussels)unclassified

The importance of additives in feeding dogs and cats: Literature review

Cappelli¹,

Manica²,

Hashimoto³

2016

Pubvet

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RESUMO.Os aditivos nas rações de cães e gatos passaram a ter grande importância no mercado de pet foods. Isto devido ao papel que os animais de estimação passaram a ocupar nos últimos anos, aproximando-se cada vez mais das pessoas e tornando-se dependentes dos seres humanos. O objetivo do estudo bibliográfico tem por finalidade destacar a importância dos aditivos, principalmente nas rações secas extrusadas, tratando das particularidades de ambas as espécies. Os aditivos tem a função de atender as exigências nutricionais que as matérias primas empregadas na fabricação das rações não fornecem. Além disso, existem aditivos que são capazes de gerar benefícios, tais como: aprimorar a digestibilidade; melhorar a qualidade das fezes e da microbiota intestinal; amenizar quadros clínicos que os animais podem sofrer, como problemas dermatológicos, intestinais e das articulações. Quando adicionados a alimentação de cães e gatos promovem benefícios ao animal a curto e longo prazo, aprimorando a saúde do pet.Palavras chave: Pet food, rações extrusadas, nutrição, saúde, animais pet. Importance of additives in feeding dogs and cats: ReviewABSTRACT. Additives in pet feed started to have big importance in the market. This due to the part of the pets passed to have in the last years, approaching more and more of the people e becoming dependents of human beings. The main of this study have the purpose to show the importance of the additives, principally in the extruded feed, addressing the particularities of both species. They function is to attempt the nutritional requirements that the feedstock used in the fabrication of pet feed don't supply. Furthermore, there are additives that are able to generate benefits, like: improving the digestibility; the faeces quality and the intestinal microbiota; ease medical conditions that animals can suffer, as skin, intestinal and articulations problems. They can provide benefits to animals in a short or a long time, improving health to pet when they are add in their feed.

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Treatment of Chronic Pain in Dogs

Hielm‐Björkman¹

2013

Pain Management in Veterinary Practice

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Improvement of Arthritic Signs in Dogs Fed Green-Lipped Mussel (Perna canaliculus)

Cited by 57 publications

References 2 publications

Effects of dietary calcium fructoborate supplementation on joint comfort and flexibility and serum inflammatory markers in dogs with osteoarthritis

Effects of dietary calcium fructoborate supplementation on joint comfort and flexibility and serum inflammatory markers in dogs with osteoarthritis

The importance of additives in feeding dogs and cats: Literature review

Treatment of Chronic Pain in Dogs

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