2018
DOI: 10.2323/jgam.2017.07.002
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Improvement of bilirubin oxidase productivity of <i>Myrothecium verrucaria</i> and studies on the enzyme overproduced by the mutant strain in the solid-state fermentation

Abstract: Bilirubin oxidase has applications in the health and environmental sectors. Hence, several attempts have been made to increase enzyme yields. However, improvements were not very high. We report here the development of a mutant strain of Myrothecium verrucaria by using UV-rays, which produced 28.8 times more enzyme compared with the parent and was higher than the yields reported in earlier submerged cultures. The mutant strain produced 35.6 times more enzyme than the parent in solid-state fermentation, which is… Show more

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Cited by 4 publications
(1 citation statement)
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“…Considering the relevance of copper and the redox nature of the degradation, we speculated that the degradation could be a more general feature for copper-containing proteins, particularly for multi-copper oxidases (MCOs). Bilirubin oxidase, an endogenous protein, is a copper-containing polyphenol oxidase that shares similar copper coordination structure CuSS*N2 (S = Cys, S* = Met, N = His) as the ceruloplasmin family 13,[50][51][52] . As expected, we observed faint cleaved bands from the mixture of FAM-Aβ42 and bilirubin oxidase (BO) (Figure 4a).…”
Section: Degradation By Ascorbate Oxidase and Other Multiplecopper Ox...mentioning
confidence: 99%
“…Considering the relevance of copper and the redox nature of the degradation, we speculated that the degradation could be a more general feature for copper-containing proteins, particularly for multi-copper oxidases (MCOs). Bilirubin oxidase, an endogenous protein, is a copper-containing polyphenol oxidase that shares similar copper coordination structure CuSS*N2 (S = Cys, S* = Met, N = His) as the ceruloplasmin family 13,[50][51][52] . As expected, we observed faint cleaved bands from the mixture of FAM-Aβ42 and bilirubin oxidase (BO) (Figure 4a).…”
Section: Degradation By Ascorbate Oxidase and Other Multiplecopper Ox...mentioning
confidence: 99%