Improvement of Curcumin Bioavailability for Medical Applications

Her, Chithdavone; Venier-Julienne, Marie-Claire; Roger, Émilie

doi:10.4172/2167-0412.1000326

Cited by 28 publications

(21 citation statements)

References 147 publications

(177 reference statements)

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“…Many specific bioactivities of GA and GA derivatives have been reported. The poor aqueous solubility of natural products result in short retention time and poor bioavailability ( Coimbra et al, 2011 ; Dewitte et al, 2016 ; Dymarska et al, 2018 ; Her et al, 2018 ). Glycosylation has been implemented to improve the solubility of hydrophobic natural products, as well as their pharmacodynamics ( Nam et al, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

Highly Efficient Biosynthesis of Glycyrrhetinic Acid Glucosides by Coupling of Microbial Glycosyltransferase to Plant Sucrose Synthase

Ali

Chang

Yan

et al. 2021

Front. Bioeng. Biotechnol.

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Glycyrrhetinic acid (GA) is a principal bioactive pentacyclic triterpenoid from Glycyrrhiza uralensis. Uridine diphosphate-dependent glycosyltransferases (UGTs) have been widely used to catalyze glycosylation of diverse nature products for the development of potential therapeutic compounds. In this study, we have characterized a UGT109A3 from Bacillus subtilis, which can glycosylate both the free C3 hydroxyl and C30 carboxyl groups of GA to yield a unique 3, 30-O-β-D-diglucoside-GA. By coupling the microbial UGT109A3 to plant sucrose synthase (SUS), GA-diglucoside could be biosynthesized in an efficient and economical way. With a fed-batch glycosylation, a large scale of GA-diglucoside (6.26 mM, 4.98 g/L in 8 h) could be enzymatically transformed from GA. The obtained GA-diglucoside showed a significant water solubility improvement of around 3.4 × 103 fold compared with that of the parent GA (29 μM). Moreover, it also exhibited dose-dependent cytotoxicity toward human colon carcinoma Caco-2 cell line according to MTT assay, having an IC50 at 160 μM. This study not only establishes efficient platform for producing GA-glucosides, but is also valuable for developing further the biosynthesis of other complex glycosylated natural products.

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Section: Resultsmentioning

confidence: 99%

Highly Efficient Biosynthesis of Glycyrrhetinic Acid Glucosides by Coupling of Microbial Glycosyltransferase to Plant Sucrose Synthase

Ali

Chang

Yan

et al. 2021

Front. Bioeng. Biotechnol.

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“…Curcumin is generally a yellow powder, and it is an effective constituent of the Indian spice turmeric, which is extracted from dried Curcuma longa plant [39,40]. Turmeric has three major components ( Figure 1): curcumin 1, bisdemethoxycurcumin 2 and demethoxycurcumin 3, and curcumin is the most abundant and active component [41]. Curcumin and its analogues have been reported to possess anticancer activity on several cancer cell lines, such as lung, colorectal, ovarian, pancreatic, breast carcinoma, oral, and melanoma cells.…”

Section: Curcumin In Cancer Therapymentioning

confidence: 99%

Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

Alven

Aderibigbe

2020

Nanomaterials

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Cancer remains a heavy health burden resulting in a high rate of mortality around the world. The presently used anticancer drugs suffer from several shortcomings, such as drug toxicity, poor biodegradability and bioavailability, and poor water solubility and drug resistance. Cancer is treated effectively by combination therapy whereby two or more anticancer drugs are employed. Most of the combination chemotherapies result in a synergistic effect and overcome drug resistance. Furthermore, the design of polymer-based nanocarriers for combination therapy has been reported by several researchers to result in promising therapeutic outcomes in cancer treatment. Curcumin exhibits good anticancer activity but its poor bioavailability has resulted in its incorporation into several polymer-based nanocarriers resulting in good biological outcomes. Furthermore, the incorporation of curcumin together with other anticancer drugs have been reported to result in excellent therapeutic outcomes in vivo and in vitro. Due to the potential of polymer-based nanocarriers, this review article will be focused on the design of polymer-based nanocarriers loaded with curcumin together with other anticancer drugs.

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“…It should be noted that in several studies, the test item was not free curcumin but nanoparticles loaded with curcumin produced for pharmaceutical purposes to increase its bioavailability (reviewed by Her et al, 2018). A number of studies were designed with the aim to demonstrate the alleged protective properties of curcumin against the effects of some genotoxic substances (doxorubicin, cisplatin, cyclophosphamide perfluorooctane sulfonate and b-cyfluthrin).…”

Section: Genotoxicitymentioning

confidence: 99%

Safety and efficacy of turmeric extract, turmeric oil, turmeric oleoresin and turmeric tincture from Curcuma longa L. rhizome when used as sensory additives in feed for all animal species

Additives¹,

Bampidis²,

Azimonti³

et al. 2020

EFS2

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Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of turmeric extract, turmeric oil, turmeric oleoresin and turmeric tincture from Curcuma longa L. rhizome when used as sensory additives in feed and in water for drinking for all animal species. The FEEDAP Panel concludes that the additives under consideration are safe at the maximum proposed use levels: (i) turmeric extract at 15 mg/kg complete feed (or in water for drinking at comparable exposure) for all animal species; (ii) turmeric essential oil at 80 mg/kg feed for veal calves (milk replacer) and 20 mg/kg complete feed (or 20 mg/L) for all other species; (iii) turmeric oleoresin at 30 mg/kg complete feed (or 30 mg/L) for chickens for fattening and laying hens and 5 mg/kg complete feed (or 5 mg/L) for pigs, veal calves, cattle for fattening and dairy cows, sheep, goats, horses, rabbits and fish; (iv) turmeric tincture at 0.8 mL/L water for drinking for poultry, 6 mL per head and day for horses and 0.05 mL tincture/kg complete feed for dogs. No concerns for consumers were identified following the use of the additives at the proposed use level in animal nutrition. Turmeric extract, turmeric oil, turmeric oleoresin and turmeric tincture should be considered as irritants to skin and eyes and the respiratory tract and as skin sensitisers. The use of the additives in feed is not expected to pose a risk for the environment. Since turmeric and its preparations are recognised to flavour food and their function in feed would be essentially the same as that in food, no further demonstration of efficacy is considered necessary.

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Improvement of Curcumin Bioavailability for Medical Applications

Abstract: Curcumin, a natural polyphenol isolated from the rhizomes of the turmeric plant (Curcuma longa Linn), is well known for its antioxidant and anti-inflammatory properties. Curcumin is currently marketed as a dietary supplement in several countries (United States

Cited by 28 publications

References 147 publications

Highly Efficient Biosynthesis of Glycyrrhetinic Acid Glucosides by Coupling of Microbial Glycosyltransferase to Plant Sucrose Synthase

Highly Efficient Biosynthesis of Glycyrrhetinic Acid Glucosides by Coupling of Microbial Glycosyltransferase to Plant Sucrose Synthase

Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

Safety and efficacy of turmeric extract, turmeric oil, turmeric oleoresin and turmeric tincture from Curcuma longa L. rhizome when used as sensory additives in feed for all animal species

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