Improvement of cyanobacterial-killing biologically derived substances (BDSs) using an ecologically safe and cost-effective naphthoquinone derivative

Joo, Jae-Hyoung; Wang, Pengbin; Park, Bum Soo; Byun, Jeong-Hwan; Choi, Hye Jeong; Kim, Seong Hun; Han, Moonsik

doi:10.1016/j.ecoenv.2017.02.006

Cited by 11 publications

(7 citation statements)

References 49 publications

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“…32 Therefore, much attention has been paid to developing new algaecides with low toxicity, high selectivity, and eco-friendly performance. 33 In this study, Q2 displayed significant selective algicidal effects against M. aeruginosa at a low concentration (0.5 mg/L), while the commercial chemical diuron suppressed the growth of M. aeruginosa and C. vulgaris without selectivity. This indicates that Q2 has the potential of being a promising algaecide for the alleviation of M. aeruginosa-dependent blooms.…”

Section: ■ Discussionmentioning

confidence: 60%

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Development of a Potentially New Algaecide for Controlling Harmful Cyanobacteria Blooms Which is Ecologically Safe and Selective

Feng

Huang

et al. 2022

J. Agric. Food Chem.

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Harmful cyanobacterial blooms (HCBs) caused by Microcystis aeruginosa are of great concern as they negatively affect the aquatic environment and human health. Chemical methods could rapidly eradicate HCBs and have been used for many decades. However, many chemical reagents are not recommended to eliminate HCBs in the long term, given the possible destructive and toxic effects of the chemicals employed on non-target aquatic organisms. We developed a new algaecide, 2-((1,3,4-thiadiazol-2-yl)thio)-N-(4-chlorophenyl) acetamide (Q2), to control harmful cyanobacteria while being environmentally friendly and selective. In our study, Q2 effectively inhibited cyanobacterial growth, especially of M. aeruginosa, but did not affect eukaryotic algae in test concentrations. A critical mechanism was revealed by transcriptome and metagenomic results showing that Q2 affects multiple cellular targets of cyanobacteria for HCB control, including the destruction of organelles, damage in the photosynthesis center, as well as inhibition of gas vesicle growth, and these changes can be highly relevant to the decrease of quorum-sensing functional KEGG pathways. Furthermore, Q2 did not affect the microbial composition and could recover the disrupted aquatic functional pathways in a short period. This is different from the impact on ecosystem functioning of the traditionally used harmful algaecide diuron. All these results verified that Q2 could be friendly to the aquatic environment, providing a new directional choice in managing HCBs in the future.

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Section: ■ Discussionmentioning

confidence: 60%

“…aeruginosa dominated the phytoplankton community and caused a recent drinking water crisis . Therefore, much attention has been paid to developing new algaecides with low toxicity, high selectivity, and eco-friendly performance . In this study, Q2 displayed significant selective algicidal effects against M.…”

Section: Discussionmentioning

confidence: 89%

Development of a Potentially New Algaecide for Controlling Harmful Cyanobacteria Blooms Which is Ecologically Safe and Selective

Feng

Huang

et al. 2022

J. Agric. Food Chem.

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“…Although observing the effect of plant extracts on the algal growth (in terms of inhibition rate) is the main purpose of this study, the mode of algal physiological progression can help understand the causes of this phenomenon, providing an insight into modifying the materials and extraction technologies for field implementation [47,48]. The algicidal substances used against HABs were involved in various physiological processes, including oxidative damage, interruption of the electron transfer chain of PSII, cell division inhibition and DNA damage [49,50].…”

Section: Of Physiological Progressionmentioning

confidence: 99%

Algicidal Activity of Cyperus rotundus Aqueous Extracts Reflected by Photosynthetic Efficiency and Cell Integrity of Harmful Algae Phaeocystis globosa

Lan

Chen

Gou

et al. 2020

Water

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Phaeocystis globosa is regarded as a notoriously harmful algal bloom species. Suppressing harmful algae using algicidal substances extracted from plants is considered an effective method. The physiological and biochemical processes of P. globosa were explored by exposure to different concentrations of aqueous extracts of Cyperus rotundus. All treatments indicated various inhibitory effects on the algal growth compared to the control samples without adding extracts. At 48 h, the 4, 8, and 16 mg/mL treatment groups showed a significant inhibitory effect, consistent with a decrease in the chlorophyll-a content and photosynthetic efficiency. The images of the transmission electron microscope (TEM) further confirmed that a subset of the cells in the treatment groups exhibited morphological anomalies. The algicidal active substances were mainly identified as phenolic acids containing maximal content of quinic acid in aqueous extracts according to the results of ultra-high-performance liquid chromatography-tandem time-of-flight mass spectrometer (UPLC-HRMS). The 50% anti-algal effect concentration of quinic acid was 22 mg/L at 96 h (EC50–96h). Thus, the phenolic acids might be considered as major inhibitors of the growth of P. globosa. These results demonstrated that the aqueous extracts of C. rotundus could potentially control the growth of P. globosa.

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“…Several ways such as applications of biological agents, clay flocculants, chemical algaecides, and physical manipulation have been utilized to control HABs [8][9][10][11][12][13][14]. Among them, application of chemical algaecide is considered as an effective and popular technique [15,16].…”

Section: Introductionmentioning

confidence: 99%

Laboratory studies of the algaecide GreenTD: stability, algaecidal activity and reduction of microcystin production

et al. 2021

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GreenTD (Dichlorobenzyl derivative, MW 362.17) is a new dichlorobenzyl derivative algaecide. It is effective and selective against harmful algal blooms (HABs). HABs cause serious problems for public health and fishery industries. Algae that cause HABs include Microcystis spp., Anabaena spp., and Aphanizomenon spp. Blooms of toxin-producing Microcystis aeruginosa occur regularly in fresh water where is rich in nitrogen and phosphorus nutrients. Environmental fate studies are needed to investigate the degradation of GreenTD. In the present study, we studied the persistence of GreenTD (90% aqueous solution) in water and toxic effects GreenTD on M. aeruginosa and reduction of microcystin production in the culture media. GreenTD was added in the water pots and microcystis media tubes at levels of 25 g/0.1 ha (0.5 mg/kg) and 50 g/0.1 ha (1.0 mg/kg). Samples were collected after 1, 3, 5, 7 and 14 days. The residues of GreenTD and microcystins in water and the media were determined using high performance liquid chromatography-diode array detection and ultra-performance liquid chromatography-tandem mass spectrometry, respectively. The half-life of GreenTD at concentrations of 0.5 and 1.0 mg/kg was 4.5 and 3.6 days, respectively. This result presents a safety level suitable for the acceptable guideline of water residue. The average recoveries of microcystins RR, YR, LR, and LA were 106–115%, 103–110%, 96–105% and 89–113% in the microcystis media, respectively. The limit of detection of (LOD) the microcystins was 0.1 µg/kg. No microcystins in the media were detected at the LOD (0.1 µg/kg). GreenTD at concentrations of 0.2 and 0.5 µg/kg had a 100% of control efficacy of M. aeruginosa. No growth of the blue-green algae was observed after 14 days of GreenTD application.

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Improvement of cyanobacterial-killing biologically derived substances (BDSs) using an ecologically safe and cost-effective naphthoquinone derivative

Cited by 11 publications

References 49 publications

Development of a Potentially New Algaecide for Controlling Harmful Cyanobacteria Blooms Which is Ecologically Safe and Selective

Development of a Potentially New Algaecide for Controlling Harmful Cyanobacteria Blooms Which is Ecologically Safe and Selective

Algicidal Activity of Cyperus rotundus Aqueous Extracts Reflected by Photosynthetic Efficiency and Cell Integrity of Harmful Algae Phaeocystis globosa

Laboratory studies of the algaecide GreenTD: stability, algaecidal activity and reduction of microcystin production

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