Improvement of Drug Release and Compatibility between Hydrophilic Drugs and Hydrophobic Nanofibrous Composites

Abstract

Electrospinning is a flexible polymer processing method to produce nanofibres, which can be applied in the biomedical field. The current study aims to develop new electrospun hybrid nanocomposite systems to benefit the sustained release of hydrophilic drugs with hydrophobic polymers. In particular, electrospun hybrid materials consisting of polylactic acid (PLA):poly(ε-caprolactone) (PCL) blends, as well as PLA:PCL/halloysite nanotubes-3-aminopropyltriethoxysilane (HNT-ASP) nanocomposites were developed in order to achieve sustained release of hydrophilic drug tetracycline hydrochloride (TCH) using hydrophobic PLA:PCL nanocomposite membranes as a drug carrier. The impact of interaction between two commonly used drugs, namely TCH and indomethacin (IMC) and PLA:PCL blends on the drug release was examined. The drug release kinetics by fitting the experimental release data with five mathematical models for drug delivery were clearly demonstrated. The average nanofiber diameters were found to be significantly reduced when increasing the TCH concentration due to increasing solution electrical conductivity in contrast to the presence of IMC. The addition of both TCH and IMC drugs to PLA:PCL blends reduced the crystallinity level, glass transition temperature (Tg) and melting temperature (Tm) of PCL within the blends. The decrease in drug release and the impairment elimination for the interaction between polymer blends and drugs was accomplished by mobilising TCH into HNT-ASP for their embedding effect into PLA:PCL nanofibres. The typical characteristic was clearly identified with excellent agreement between our experimental data obtained and Ritger–Peppas model and Zeng model in drug release kinetics. The biodegradation behaviour of nanofibre membranes indicated the effective incorporation of TCH onto HNT-ASP.

Electrospun nanofibers of poly (lactic acid)/poly (ε‐caprolactone) blend for the controlled release of levetiracetam

“…In the electrospinning process, due to the rapid evaporation of solvent and high ionic interaction, a part of the drug accumulates on the nanofibers surface. [ 72 ] The drug absorbed on the nanofibers surface causes rapid release of the drug from the amorphous regions at early times (burst region). This study performed drug release at 37°C in a phosphate buffer solution.…”

Development, Evaluation, and Molecular Dynamics Study of Ampicillin-Loaded Chitosan–Hyaluronic Acid Films as a Drug Delivery System

“…However, the drug content was found higher for I3 (6% HA) than I1 (12% HA). This might be attributed to the phenomenon that competition between solvent accessibility to the system and the binding energy of ampicillin to the system affected the results …”

“…This might be attributed to the phenomenon that competition between solvent accessibility to the system and the binding energy of ampicillin to the system affected the results. 41 3.2.2. Determination of Ampicillin Release from PECs.…”

Enhanced Inhibition of Drug-Resistant Escherichia coli by Tetracycline Hydrochloride-Loaded Multipore Mesoporous Silica Nanoparticles

“…Figure S3 (Supplementary Materials) showed the surface zeta potential of MSNs before and after TCH loading in PBS solution. We noted that the surface charges of all three MSNs showed very small increases (1-2 mV) after TCH loading, indicating that most of the TCH molecule was immobilized in the mesopores of MSNs by non-covalent interactions instead of modifying on the surface of MSNs [19,20]. TCH release behavior from MSNs was examined under conditions with a fixed initial TCH concentration (0.2 mg/mL) in PBS.…”