Improvement of drug safety by the use of lipid-based nanocarriers

Lim, Sok Bee; Banerjee, Amrita; Önyüksel, Hayat

doi:10.1016/j.jconrel.2012.06.002

Cited by 274 publications

(152 citation statements)

References 132 publications

(207 reference statements)

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“…Aspirin and metformin may form an acid-base complex and be encapsulated in the nanoparticles at high efficiency. Similar types of nanoparticles have been reported to be stable and suitable for oral delivery (108). They are absorbed through the lymphatic system and then enter the systemic circulation, hence passing gastrointestinal metabolism (109,110).…”

Section: Discussionmentioning

confidence: 80%

Repurposing of Metformin and Aspirin by Targeting AMPK-mTOR and Inflammation for Pancreatic Cancer Prevention and Treatment

Yang

DiPaola

et al. 2014

Cancer Prevention Research

138

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Pancreatic cancer, as the fourth leading cause of cancer-related deaths, carries a poor prognosis with a median survival of 6 months and a dismal 5-year survival rate of 3% to 5%. These statistics highlight an urgent need for novel chemopreventive and therapeutic strategies for this malignancy. Metformin and aspirin have been explored as two emerging cancer chemoprevention agents for different types of cancers, including pancreatic cancer. Here, we review the effects of both metformin and aspirin on pancreatic tumorigenesis and their potential actions in pancreatic cancer. Special attention is paid to their effects on the important signaling pathways of pancreatic cancer development as well as possible mechanisms for synergy between these two agents. For metformin, the most important mechanism may involve the inhibition of mTOR signaling via AMP-activated protein kinase (AMPK)-dependent and -independent pathways. For aspirin, the major mechanism is the anti-inflammatory action through the inhibition of COX-1/COX-2 and modulation of the NFkB or STAT3 pathway. In addition, aspirin may activate AMPK, and both agents may affect Notch, Wnt/b-catenin, and other signaling pathways. The combination of metformin and aspirin will provide additive and possibly synergistic effects for the prevention and treatment of pancreatic cancer. Cancer Prev Res; 7(4); 388-97. Ó2014 AACR.

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Section: Discussionmentioning

confidence: 80%

Repurposing of Metformin and Aspirin by Targeting AMPK-mTOR and Inflammation for Pancreatic Cancer Prevention and Treatment

Yang

DiPaola

et al. 2014

Cancer Prevention Research

138

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“…Liposomes have been intensively investigated and serve as one of the most biocompatible biomedical drug delivery systems for clinical applications 1,2 . They are mainly composed of phospholipids and cholesterol, both of which are biocompatible compounds mimicking parts of natural cell membranes.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for <em>In Vivo</em> Optical Imaging

Tansi

Rüger

Rabenhold

et al. 2015

JoVE

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Optical imaging offers a wide range of diagnostic modalities and has attracted a lot of interest as a tool for biomedical imaging. Despite the enormous number of imaging techniques currently available and the progress in instrumentation, there is still a need for highly sensitive probes that are suitable for in vivo imaging. One typical problem of available preclinical fluorescent probes is their rapid clearance in vivo, which reduces their imaging sensitivity. To circumvent rapid clearance, increase number of dye molecules at the target site, and thereby reduce background autofluorescence, encapsulation of the near-infrared fluorescent dye, DY-676-COOH in liposomes and verification of its potential for in vivo imaging of inflammation was done. DY-676 is known for its ability to self-quench at high concentrations. We first determined the concentration suitable for self-quenching, and then encapsulated this quenching concentration into the aqueous interior of PEGylated liposomes. To substantiate the quenching and activation potential of the liposomes we use a harsh freezing method which leads to damage of liposomal membranes without affecting the encapsulated dye. The liposomes characterized by a high level of fluorescence quenching were termed Lip-Q. We show by experiments with different cell lines that uptake of Lip-Q is predominantly by phagocytosis which in turn enabled the characterization of its potential as a tool for in vivo imaging of inflammation in mice models. Furthermore, we use a zymosan-induced edema model in mice to substantiate the potential of Lip-Q in optical imaging of inflammation in vivo. Considering possible uptake due to inflammation-induced enhanced permeability and retention (EPR) effect, an always-on liposome formulation with low, non-quenched concentration of DY-676-COOH (termed LipdQ) and the free DY-676-COOH were compared with Lip-Q in animal trials. Video LinkThe video component of this article can be found at

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“…Liposomes have been shown to be safe for human use, and they can be a suitable platform for multimodal imaging (13)(14)(15). In addition, it is well known that macrophages phagocytize particles such as liposomes (16,17).…”

mentioning

confidence: 99%

Development of¹¹¹In-Labeled Liposomes for Vulnerable Atherosclerotic Plaque Imaging

et al. 2013

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Improvement of drug safety by the use of lipid-based nanocarriers

Cited by 274 publications

References 132 publications

Repurposing of Metformin and Aspirin by Targeting AMPK-mTOR and Inflammation for Pancreatic Cancer Prevention and Treatment

Repurposing of Metformin and Aspirin by Targeting AMPK-mTOR and Inflammation for Pancreatic Cancer Prevention and Treatment

Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for <em>In Vivo</em> Optical Imaging

Development of¹¹¹In-Labeled Liposomes for Vulnerable Atherosclerotic Plaque Imaging

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Improvement of drug safety by the use of lipid-based nanocarriers

Cited by 274 publications

References 132 publications

Repurposing of Metformin and Aspirin by Targeting AMPK-mTOR and Inflammation for Pancreatic Cancer Prevention and Treatment

Repurposing of Metformin and Aspirin by Targeting AMPK-mTOR and Inflammation for Pancreatic Cancer Prevention and Treatment

Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for <em>In Vivo</em> Optical Imaging

Development of111In-Labeled Liposomes for Vulnerable Atherosclerotic Plaque Imaging

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Product

Resources

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Development of¹¹¹In-Labeled Liposomes for Vulnerable Atherosclerotic Plaque Imaging