Improvement of extraction and stability of anthocyanins, the natural red pigment from roselle calyces using supercritical carbon dioxide extraction

Idham, Zuhaili; Putra, Nicky Rahmana; Aziz, Ahmad Hazim Abdul; Zaini, Ahmad Syahmi; Rasidek, Noor Azwani Mohd; Mili, Norlisa; Yunus, Mohd Azizi Che

doi:10.1016/j.jcou.2021.101839

Cited by 50 publications

(27 citation statements)

References 48 publications

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“…They reported that although the extracted yield fraction depended especially on the extraction temperature and was slightly influenced by the extraction pressure, the increasing operating pressures at the constant operating temperature resulted in the increasing extracted yield fraction, including the total flavonoid content. Idham et al also reported that the increasing operating pressure may increase the total anthocyanin content value when they carried out experiments for the natural red pigment extraction from the Hibiscus sabdariffa matrix using the SC-CO 2 extraction system . They explained that the increasing operating pressure could give a beneficial effect due to the increasing CO 2 density and diffusivity.…”

Section: Resultsmentioning

confidence: 98%

“…Idham et al also reported that the increasing operating pressure may increase the total anthocyanin content value when they carried out experiments for the natural red pigment extraction from the Hibiscus sabdariffa matrix using the SC-CO 2 extraction system. 22 They explained that the increasing operating pressure could give a beneficial effect due to the increasing CO 2 density and diffusivity. At high operating pressures, the fluctuation of CO 2 density may occur and intensify the interaction between the CO 2 fluid as an extraction solvent and the H. sabdariffa matrix.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The operating pressure is an important variable in supercritical fluids that may enhance the solvent power and have a high effect on product selectivity. − At a constant operating temperature, the density of the fluid under supercritical conditions increases with increasing operating pressure. Because the solvent power is related to the fluid density, the increase in density may enhance the fluid solvent power, resulting in an increased extraction yield.…”

Section: Resultsmentioning

confidence: 99%

“…This may be because of the increase in the density of CO 2 under supercritical conditions, which implies that the solvent power of SC-CO 2 increases when the operating pressure is increased at a constant operating temperature, resulting in an increasing amount of extracted functional components from A. furcijuga leaves. − Saito et al conducted an experiment for phenolic compound extraction using the SC-CO 2 extraction system with green propolis and Brazilian red as raw material sources . They reported that although the extracted yield fraction depended especially on the extraction temperature and was slightly influenced by the extraction pressure, the increasing operating pressures at the constant operating temperature resulted in the increasing extracted yield fraction, including the total flavonoid content.…”

Section: Resultsmentioning

confidence: 99%

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Extraction of Functional Components from Freeze-Dried Angelica furcijuga Leaves Using Supercritical Carbon Dioxide

et al. 2022

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Angelica furcijuga (A. furcijuga), as a material for traditional Chinese medicine, has been widely used in Asian countries, such as China, Korea, and Japan, for several centuries owing to its therapeutic effects. In this study, A. furcijuga leaves were used as starting materials to extract functional substances using supercritical carbon dioxide (SC-CO2) at pressure and temperature ranges of 20–40 MPa and 40–80 °C, respectively. The extraction process was performed in a semibatch-type system with extraction times of 15–120 min. The high-performance liquid chromatography analysis indicated that kaempferol, ferulic acid, ligustilide, and butylidenephthalide as selected functional substances were successfully extracted under these operating conditions. An operating pressure of 30 MPa with an extraction time of 60 min seems to be an appropriate pressure to extract functional components from A. furcijuga leaves. The Hansen solubility parameter values and statistical analysis showed that SC-CO2 with 10% ethanol addition is a feasible tool to isolate these selected functional substances from the A. furcijuga matrix.

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Section: Resultsmentioning

confidence: 98%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Extraction of Functional Components from Freeze-Dried Angelica furcijuga Leaves Using Supercritical Carbon Dioxide

et al. 2022

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“…Besides the extraction time, the operating pressure is also a key factor in SCCO 2 extraction system. It can improve the solvent power of SCCO 2 solvent and affect the selectivity of products [ 25 , 26 , 27 ]. The fluid density including CO 2 under supercritical conditions mostly raises with raising operating pressure at a fixed operating temperature.…”

Section: Resultsmentioning

confidence: 99%

Oil removal from spent bleaching earth of vegetable oil refinery plant using supercritical carbon dioxide

Machmudah

Maulana

Norman

et al. 2022

Heliyon

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Integrating natural compounds and nanoparticle‐based drug delivery systems: A novel strategy for enhanced efficacy and selectivity in cancer therapy

Manzari‐Tavakoli,

Babajani,

Tavakoli

et al. 2024

Cancer Medicine

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Cancer remains a leading cause of death worldwide, necessitating the development of innovative and more effective treatment strategies. Conventional cancer treatments often suffer from limitations such as systemic toxicity, poor pharmacokinetics, and drug resistance. Recently, there has been growing attention to utilizing natural compounds derived from various sources as possible cancer therapeutics. Natural compounds have demonstrated diverse bioactive properties, including antioxidant, anti‐inflammatory, and antitumor effects, making them attractive candidates for cancer treatment. However, their limited solubility and bioavailability present challenges for effective delivery to cancer cells. To overcome these limitations, researchers have turned to nanotechnology‐based drug delivery systems. Nanoparticles, with their small size and unique properties, can encapsulate therapeutic agents and offer benefits such as improved solubility, prolonged drug release, enhanced cellular uptake, and targeted delivery. Functionalizing nanoparticles with specific ligands further enhances their precision in recognizing and binding to cancer cells. Combining natural compounds with nanotechnology holds great promise in achieving efficient and safe cancer treatments by enhancing bioavailability, pharmacokinetics, and selectivity toward cancer cells. This review article provides an overview of the advancements in utilizing natural substances and nanotechnology‐based drug delivery systems for cancer treatment. It discusses the benefits and drawbacks of various types of nanoparticles, as well as the characteristics of natural compounds that make them appealing for cancer therapy. Additionally, current research on natural substances and nanoparticles in preclinical and clinical settings is highlighted. Finally, the challenges and future perspectives in developing natural compound‐nanoparticle‐based cancer therapies are discussed.

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Improvement of extraction and stability of anthocyanins, the natural red pigment from roselle calyces using supercritical carbon dioxide extraction

Cited by 50 publications

References 48 publications

Extraction of Functional Components from Freeze-Dried Angelica furcijuga Leaves Using Supercritical Carbon Dioxide

Extraction of Functional Components from Freeze-Dried Angelica furcijuga Leaves Using Supercritical Carbon Dioxide

Oil removal from spent bleaching earth of vegetable oil refinery plant using supercritical carbon dioxide

Integrating natural compounds and nanoparticle‐based drug delivery systems: A novel strategy for enhanced efficacy and selectivity in cancer therapy

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