Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective

Liao, Shengnan; Wang, Yue; Cai, Shuning; Tang, Quan; Lu, Weitong; Huang, Lei; Qi, Tingting; Liao, Jinfeng

doi:10.3389/fphar.2021.664123

Cited by 73 publications

(54 citation statements)

References 207 publications

(291 reference statements)

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“…Plasmon resonance can be changed by adjusting the length-to-width ratio or effective volume of the rod ( 18 ). Therefore, it can be absorbed by the tumor tissue due to the penetration effect while maintaining a small diameter and better light absorption properties to simultaneously achieve the effect of photothermal treatment ( 30 , 31 ). Furthermore, studies have shown that gold nanorods modified with low-density lipoprotein binding domain-binding polypeptide (RLT polypeptide) have a relatively evident inhibitory effect in the gastric cancer cell.…”

Section: Gnps With Different Structuresmentioning

confidence: 99%

The Applications of Gold Nanoparticles in the Diagnosis and Treatment of Gastrointestinal Cancer

et al. 2022

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In recent years, the morbidity and mortality of gastrointestinal cancer have remained high in China. Due to the deep location of the gastrointestinal organs, such as gastric cancer, the early symptoms of cancer are not obvious. It is generally discovered at an advanced stage with distant metastasis and lymph node infiltration, making it difficult to cure. Therefore, there is a significant need for novel technologies that can effectively diagnose and treat gastrointestinal cancer, ultimately reducing its mortality. Gold nanoparticles (GNPs), a type of nanocarrier with unique optical properties and remarkable biocompatibility, have the potential to influence the fate of cancer by delivering drugs, nucleic acids to cancer cells and tissues. As a safe and reliable visualization agent, GNPs can track drugs and accurately indicate the location and boundaries of cancer, opening up new possibilities for cancer treatment. In addition, GNPs have been used in photodynamic therapy to deliver photosensitizers, as well as in combination with photothermal therapy. Therefore, GNPs can be used as a safe and effective nanomaterial in the treatment and diagnosis of gastrointestinal cancer.

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Section: Gnps With Different Structuresmentioning

confidence: 99%

The Applications of Gold Nanoparticles in the Diagnosis and Treatment of Gastrointestinal Cancer

et al. 2022

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“…AuNRs were incorporated into mesoporous silica [97,98], biodegradable polymeric matrix [99], and liposomes to facilitate the targeted release of ruthenium(II) polypyridyl complexes [100]. For more detailed information, the readers are referred to resent original papers [101][102][103][104][105][106][107][108][109] and related citations in recent reviews [77,[110][111][112][113][114][115].…”

Section: Au Nanorods (Aunrs)mentioning

confidence: 99%

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Bucharskaya

Khlebtsov

et al. 2022

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Cancer remains one of the leading causes of death in the world. For a number of neoplasms, the efficiency of conventional chemo- and radiation therapies is insufficient because of drug resistance and marked toxicity. Plasmonic photothermal therapy (PPT) using local hyperthermia induced by gold nanoparticles (AuNPs) has recently been extensively explored in tumor treatment. However, despite attractive promises, the current PPT status is limited by laboratory experiments, academic papers, and only a few preclinical studies. Unfortunately, most nanoformulations still share a similar fate: great laboratory promises and fair preclinical trials. This review discusses the current challenges and prospects of plasmonic nanomedicine based on PPT and photodynamic therapy (PDT). We start with consideration of the fundamental principles underlying plasmonic properties of AuNPs to tune their plasmon resonance for the desired NIR-I, NIR-2, and SWIR optical windows. The basic principles for simulation of optical cross-sections and plasmonic heating under CW and pulsed irradiation are discussed. Then, we consider the state-of-the-art methods for wet chemical synthesis of the most popular PPPT AuNPs such as silica/gold nanoshells, Au nanostars, nanorods, and nanocages. The photothermal efficiencies of these nanoparticles are compared, and their applications to current nanomedicine are shortly discussed. In a separate section, we discuss the fabrication of gold and other nanoparticles by the pulsed laser ablation in liquid method. The second part of the review is devoted to our recent experimental results on laser-activated interaction of AuNPs with tumor and healthy tissues and current achievements of other research groups in this application area. The unresolved issues of PPT are the significant accumulation of AuNPs in the organs of the mononuclear phagocyte system, causing potential toxic effects of nanoparticles, and the possibility of tumor recurrence due to the presence of survived tumor cells. The prospective ways of solving these problems are discussed, including developing combined antitumor therapy based on combined PPT and PDT. In the conclusion section, we summarize the most urgent needs of current PPT-based nanomedicine.

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“…Under high temperatures, normal cells can be in the heat stress state [182]. During this process, the expression of heat shock protein is upregulated, helping to reduce the damage caused by protein denaturation and inhibit the activation of apoptosis-related pathways [183]. PTT mediated by gold-based nanomaterials can induce physiological and biological changes in the surrounding tumor environment, which can maximize the cytotoxicity of PTT and improve the efficacy of secondary therapy.…”

Section: Cell Death Mechanism Induced By Pttmentioning

confidence: 99%

Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

et al. 2021

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Liposomes are attractive carriers for targeted and controlled drug delivery receiving increasing attention in cancer photothermal therapy. However, the field of creating near-infrared nanomaterial-liposome hybrid nanocarriers (NIRN-Lips) is relatively little understood. The hybrid nanocarriers combine the dual superiority of nanomaterials and liposomes, with more stable particles, enhanced photoluminescence, higher tumor permeability, better tumor-targeted drug delivery, stimulus-responsive drug release, and thus exhibiting better anti-tumor efficacy. Herein, this review covers the liposomes supported various types of near-infrared nanomaterials, including gold-based nanomaterials, carbon-based nanomaterials, and semiconductor quantum dots. Specifically, the NIRN-Lips are described in terms of their feature, synthesis, and drug-release mechanism. The design considerations of NIRN-Lips are highlighted. Further, we briefly introduced the photothermal conversion mechanism of NIRNs and the cell death mechanism induced by photothermal therapy. Subsequently, we provided a brief conclusion of NIRNs-Lips applied in cancer photothermal therapy. Finally, we discussed a synopsis of associated challenges and future perspectives for the applications of NIRN-Lips in cancer photothermal therapy.

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Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective

Cited by 73 publications

References 207 publications

The Applications of Gold Nanoparticles in the Diagnosis and Treatment of Gastrointestinal Cancer

The Applications of Gold Nanoparticles in the Diagnosis and Treatment of Gastrointestinal Cancer

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

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