Improvement of hemodynamic performance using novel helical flow vena cava filter design

Chen, Ying; Zhang, Peng; Deng, Xiaoyan; Fan, Yubo; Xing, Yongzhong; Xing, Na

doi:10.1038/srep40724

Cited by 10 publications

(12 citation statements)

References 32 publications

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“…The following models are considered: model A, in which the inducer has a large and an invariable diameter of 10 mm, and a thread pitch of 7 mm; model B, in which the inducer has a conical angle with a diameter that varied from 10 mm to 3.5 mm in the blood flow direction, and a thread pitch of 7 mm; model C, in which a helical flow inducer has a large and invariable diameter of 10 mm with a thread pitch of 27 mm; and model D, in which the helical flow inducer has an invariable small diameter of 3.5 mm, and a thread pitch of 5 mm. Compared to the previous, novel helical flow vena cava filter, and the Greenfield filter prototype [ 9 , 11 ], in these four inducers, the circular cross-section diameter of the inducer leg is 0.6 mm, and the total length of each inducer (L) is 38 mm. In the present study, we focus on the hemodynamic performance of the helical flow inducers in the vena cava.…”

Section: Methodsmentioning

confidence: 99%

“…We adopted the same methods as previously reported, whereby a circulation perfusion system was constructed [ 9 ]. A flexible and transparent plastic hose with an inner diameter of 19 mm was used for simulating the vena cava.…”

Section: Methodsmentioning

confidence: 99%

“…Wen et al numerically simulated the hemodynamic characteristics of several arteriovenous grafts with various helical shapes, and their simulation results showed the helical grafts suppress the disrupted shear stress distribution in the venous segment compared to the conventional straight graft [ 8 ]. Our previous study also demonstrated that use of a novel helical flow vena cava filter design could result in hemodynamic performance improvements in the vena cava [ 9 , 10 ]. The induction of helical flow is likely to minimize clinical risks of deep venous thrombosis and pulmonary embolisms.…”

Section: Introductionmentioning

confidence: 99%

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Study of helical flow inducers with different thread pitches and diameters in vena cava

et al. 2018

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Pulmonary embolism is a severe, potentially life-threatening condition. Inferior vena cava filters have been used to prevent recurrent pulmonary embolisms. However, the build-up of thrombosis in vena cava filters after deployment presents a severe problem to patients. Previous studies proposed that filters with helical flow are beneficial and capable of alleviating this problem. In this study, the hemodynamic performances of four typical helical flow inducers in the vena cava are determined using computational fluid dynamics simulations (steadystate and pulsatile flow) and compared. Pilot in vitro experiments were also conducted. The simulation results demonstrate that large-diameter inducers produce helical flow. Among inducers with identical diameter, those with a smaller thread pitch are more likely to induce increased helical flow. We also observed that the small thread pitch inducers can yield higher shear rates. Furthermore, a large diameter, small thread pitch helical flow inducer increases the time-averaged wall shear stress and reduces the oscillating shear index and relative residence time on the vessel wall in the vicinity of the helical flow inducer. In vitro experiments also verify that large diameter inducers generate a helical flow. A notable observation of this study is that the diameter is the key parameter that affects the induction of a helical flow. This study will likely provide important guidance for the design of interventional treatments and the deployment of filters associated with helical flow in the vena cava.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Study of helical flow inducers with different thread pitches and diameters in vena cava

et al. 2018

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“…(2) ρ((∂υ/∂t) A zero OSI value corresponds to a unidirectional shear flow, and the OSI value is 1/2 when a purely oscillatory shear case occurs [25].…”

Section: Hemodynamic Parametersmentioning

confidence: 99%

Effects of reverse deployment of cone-shaped vena cava filter on improvements in hemodynamic performance in vena cava

Chen

Deng

et al. 2021

BioMed Eng OnLine

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Background Cone-shaped vena cava filters (VCFs) are widely used to treat venous thromboembolism. However, in the long term, the problem of occlusion persists even after the filter is deployed. A previous study hypothesized that the reverse deployment of a cone-shaped VCFs may prevent filter blockage. Methods To explore this hypothesis, a comparative study of the traditional and reverse deployments of VCFs was conducted using a computational fluid dynamics approach. The distribution of wall shear stress (WSS) and shear stress-related parameters were calculated to evaluate the differences in hemodynamic effects between both conditions. In the animal experiment, we reversely deployed a filter in the vena cava of a goat and analyzed the blood clot distribution in the filter. Results The numerical simulation showed that the reverse deployment of a VCF resulted in a slightly higher shear rate on the thrombus, and no reductions in the oscillating shear index (OSI) and relative residence time (RRT) on the vessel wall. Comparing the traditional method with the reversely deployed cases, the shear rate values is 16.49 and 16.48 1/s, respectively; the minimal OSI values are 0.01 and 0.04, respectively; in the vicinity of the VCF, the RRT values are both approximately 5 1/Pa; and the WSS is approximately 0.3 Pa for both cases. Therefore, the reverse deployment of cone-shaped filters is not advantageous when compared with the traditional method in terms of local hemodynamics. However, it is effective in capturing thrombi in the short term, as demonstrated via animal experiments. The reversely deployed cone-shaped filter captured the thrombi at its center in the experiments. Conclusions Thus, the reverse deployment of cone-shaped filters is not advantageous when compared with the traditional method in terms of local hemodynamics. Therefore, we would not suggest the reverse deployment of the cone-shaped filter in the vena cava to prevent a potentially fatal pulmonary embolism.

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“…The thrombus in deep veins dislodges and flows toward the pulmonary artery, where larger emboli may cause pulmonary embolism (PE). PE is the most common complication of DVT with a high morbidity and mortality ( Aycock et al, 2014 ; Chen et al, 2017 ). Both DVT and PE are collectively referred to as venous thromboembolism (VTE) ( Yamashita et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of hemodynamic effects of different inferior vena cava filter heads using computational fluid dynamics

Wang

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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Inferior vena cava (IVC) filters are used to prevent pulmonary embolism in patients with deep vein thrombosis for whom anticoagulation is unresponsive. The head is a necessary structure for an Inferior vena cava filter (IVCF) in clinic use. At present, there are various head configurations for IVCFs. However, the effect of head pattern on the hemodynamics of IVCF is still a matter of unclear. In this study, computational fluid dynamics is used to simulate non-Newtonian blood flows around four IVCFs with different heads inside an IVC model, in which the Denali filter with a solid and hooked head is employed as a prototype, and three virtual variants are reconstructed either with a no-hook head or with a through-hole head for comparison. The simulation results show that the through-hole head can effectively avoid the recirculation region and weaken the blood flow stasis closely downstream the IVCF head. The shape change of the filter head has no significant effect on the blood flow acceleration inside the IVCF cone as well as little influence on the wall shear stress (WSS) distribution on the filter wire surface and IVC wall. The structure pattern of filter head greatly affects the flow resistance of its own. However, the flow drag of filter head only occupies a small proportion of the total resistance of IVCF. Therefore, to reduce the flow resistance of an IVCF should optimize its whole structure.

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Improvement of hemodynamic performance using novel helical flow vena cava filter design

Cited by 10 publications

References 32 publications

Study of helical flow inducers with different thread pitches and diameters in vena cava

Study of helical flow inducers with different thread pitches and diameters in vena cava

Effects of reverse deployment of cone-shaped vena cava filter on improvements in hemodynamic performance in vena cava

Evaluation of hemodynamic effects of different inferior vena cava filter heads using computational fluid dynamics

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