Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters

Crisosto, Nicolás; Echiburú, Bárbara; Maliqueo, Manuel; Pérez, Virginia; Guevara, Amanda Ladrón de; Preisler, Jessica; Sánchez, Francisco Javier Sierro; Sir-Petermann, Teresa

doi:10.1016/j.fertnstert.2011.10.002

Cited by 52 publications

(66 citation statements)

References 44 publications

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“…It may explain the lack of relationship between circulating androgens and AMH levels, which is in accordance with previously published studies conducted by one research team [13,14,15,16]. …”

Section: Discussionsupporting

confidence: 91%

“…This is in contradiction to previously published studies conducted by a single research team [13,14,15,16]. It should be noted that both FSH and AMH are markers of functional ovarian reserve reflecting distinctively different stages of folliculogenesis [21].…”

Section: Discussioncontrasting

confidence: 68%

“…Recently, it has been shown that hyperandrogenism and hyperinsulinemia during pregnancy in PCOS women may be related to an increased ovarian follicular mass of their daughters, and are associated with higher circulating AMH levels at 2-3 months of the infant's age. Treatment with metformin caused improvement of the endocrine-metabolic status of PCOS mothers followed by reduced AMH levels in their daughters [13]. Moreover, the same research group described higher levels of AMH in daughters of PCOS women (PCOSd) at the age of 4-7 years as well as at the peripubertal period in all Tanner stages [14,15,16].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the same research group described higher levels of AMH in daughters of PCOS women (PCOSd) at the age of 4-7 years as well as at the peripubertal period in all Tanner stages [14,15,16]. Thus, the authors suggested that PCOSd appear to show an increased follicular mass established during the early development, and persisting at puberty [13,14,15,16]. …”

Section: Introductionmentioning

confidence: 99%

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Circulating Anti-Müllerian Hormone Levels in Daughters of Women with and without Polycystic Ovary Syndrome

Olszanecka-Glinianowicz¹,

Zachurzok

Drosdzol–Cop

et al. 2016

Horm Res Paediatr

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Background/Aims: The aim of this study was to assess whether circulating anti-Müllerian hormone (AMH) levels in daughters of women with polycystic ovary syndrome (PCOSd) correspond with clinical and biochemical features of hyperandrogenism, polycystic ovary morphology and menstrual cycle disturbances. Methods: Menstrual cycle disturbances, hirsutism, acne and ultrasonographic ovarian morphology were assessed in 75 girls aged 13-18 years (35 PCOSd and 40 daughters of healthy women). Serum gonadotropins, androgens, sex hormone-binding globulin and plasma AMH were measured in a fasting state, and the free androgen index was calculated. Results: A significant correlation between the AMH level and mean ovary volume was found (r = 0.36; p < 0.01). AMH levels were not related to hirsutism, acne and polycystic ovary morphology. Significantly higher AMH levels were found only in PCOSd with irregular menstruation or secondary amenorrhea. The results of logistic regression analysis showed that in that group for each 1-ng/ml increase in the AMH level, the odds ratio of the PCOS occurrence in the future was increased 1.27 times (95% CI: 1.09-1.47; p < 0.01). Conclusions: A higher AMH level in PCOSd is associated with menstrual cycle disturbances and larger ovarian volume but not with clinical and biochemical features of hyperandrogenism. Thus, the risk for PCOS development among genetically predisposed girls may be related to increased AMH levels.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Circulating Anti-Müllerian Hormone Levels in Daughters of Women with and without Polycystic Ovary Syndrome

Olszanecka-Glinianowicz¹,

Zachurzok

Drosdzol–Cop

et al. 2016

Horm Res Paediatr

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“…En las madres, se observó una disminución signifi cativa de los niveles de insulina y andrógenos séricos y un aumento de la sensibilidad insulínica 40 . Por lo tanto, la administración de metformina durante el embarazo a la madre con SOP, parece tener un efecto favorable sobre las alteraciones endocrino-metabólicas que presentan estas pacientes, disminuyendo el desarrollo de diabetes gestacional y previniendo el exceso de andrógenos para el feto, lo que se traduce en una disminución de niños con extremos de peso al nacer y una disminución de la masa folicular de las hijas.…”

Section: ¿Cómo Infl Uye El Sop Sobre El Embarazo?unclassified

Síndrome de ovario poliquístico y embarazo

et al. 2012

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Polycystic ovary syndrome (PCOS) is a common endocrine metabolic dysfunction closely associated with insulin resistance and obesity, which predisposes to pregnancy complications and prenatal programming of the offspring. The aim of this review is to report our experience in PCOS patients, caracterizada por oligo-ovulación e hiperandrogenismo, lo que compromete la función reproductiva de la mujer. Su etiología es incierta y se encuentra en estrecha asociación a la resistencia insulínica (RI), la que juega un papel preponderante en su fi siopatología y en las consecuencias metabólicas a largo plazo, entre las que destacan el desarrollo precoz de síndrome metabólico, diabetes tipo 2 y enfermedad cardiovascular 2 .Las manifestaciones clínicas del SOP son heterogéneas y varían de acuerdo a la edad de la paciente. Se ha propuesto que este trastorno acompañaría a la mujer durante toda la vida, pudiendo manifestarse desde etapas muy tempranas del desarrollo sexual hasta la senectud [3][4][5][6] . El SOP se caracteriza por presentar una morfología ovárica típica con múltiples folículos en crecimiento, aumento del estroma ovárico e hipersecreción de andrógenos, lo que sugiere que las alteraciones de la esteroidogénesis y de la foliculogénesis serían eventos centrales de este

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Hyperandrogenism and Polycystic ovary syndrome: Effects in pregnancy and offspring development

Abruzzese

Silva

Velázquez

et al. 2022

WIREs Mechanisms of Disease

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Polycystic ovary syndrome (PCOS) is one of the major endocrine disorders affecting women of reproductive age. Its etiology remains unclear. It is suggested that environmental factors, and particularly the intrauterine environment, play key roles in PCOS development. Besides the role of androgens in PCOS pathogenesis, exposure to endocrine disruptors, as is Bisphenol A, could also contribute to its development. Although PCOS is considered one of the leading causes of ovarian infertility, many PCOS patients can get pregnant. Some of them by natural conception and others by assisted reproductive technique treatments. As hyperandrogenism (one of PCOS main features) affects ovarian and uterine functions, PCOS women, despite reaching pregnancy, could present high-risk pregnancies, including implantation failure, an increased risk of gestational diabetes, preeclampsia, and preterm birth. Moreover, hyperandrogenism may also be maintained in these women during pregnancy. Therefore, as an altered uterine milieu, including hormonal imbalance, could affect the developing organisms, monitoring these patients throughout pregnancy and their offspring development is highly relevant. The present review focuses on the impact of androgenism and PCOS on fertility issues and pregnancy-related outcomes and offspring development. The evidence suggests that the increased risk of pregnancy complications and adverse offspring outcomes of PCOS women would be due to the factors involved in the syndrome pathogenesis and the related co-morbidities. A better understanding of the involved mechanisms is still needed and could contribute to a better management of these women and their offspring.

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Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters

Cited by 52 publications

References 44 publications

Circulating Anti-Müllerian Hormone Levels in Daughters of Women with and without Polycystic Ovary Syndrome

Circulating Anti-Müllerian Hormone Levels in Daughters of Women with and without Polycystic Ovary Syndrome

Síndrome de ovario poliquístico y embarazo

Hyperandrogenism and Polycystic ovary syndrome: Effects in pregnancy and offspring development

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