Research Methods and Procedures:According to a sampling scheme based on BMI, 33 adult obese women (BMI Ն 30) and 30 adult normal-weight women (BMI Ͼ 18.5 and Ͻ 25 kg/m 2 ) were recruited for this study. Women with chronic inflammatory diseases or acute pathology were excluded. Glucose, insulin, leptin, lipids, and tumor necrosis factor ␣ (TNF␣) were measured in fasting plasma samples. Insulin resistance was estimated through the homeostasis model assessment for insulin resistance method. The Ala54Thr allelic variant was determined by polymerase chain reaction, followed by restriction fragment-length polymorphism analysis. Results: The Thr54 allele was more frequent in obese than in nonobese women (47.0% vs. 31.7; p ϭ 0.08). Among obese women, higher TNF␣ concentrations were found when comparing the Thr54/Thr54 genotype (30.0 Ϯ 7.1 pg/mL) with either the Ala54/Thr54 genotype (21.2 Ϯ 8.4 pg/mL) or the Ala54/Ala44 genotype (20.1 Ϯ 7.0 pg/mL) (p Ͻ 0.05). In addition, higher fasting plasma insulin and leptin levels were found among Thr54/Thr54 homozygotes compared with the other genotypes (p Ͻ 0.05). Discussion: Our results suggest that the Ala54Thr polymorphism of the FABP2 gene is associated with obesity and insulin resistance. The effect of this polymorphism might be mediated by elevated production of TNF␣.

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Polycystic ovary syndrome (PCOS) is a common endocrine metabolic dysfunction closely associated with insulin resistance and obesity, which predisposes to pregnancy complications and prenatal programming of the offspring. The aim of this review is to report our experience in PCOS patients, caracterizada por oligo-ovulación e hiperandrogenismo, lo que compromete la función reproductiva de la mujer. Su etiología es incierta y se encuentra en estrecha asociación a la resistencia insulínica (RI), la que juega un papel preponderante en su fi siopatología y en las consecuencias metabólicas a largo plazo, entre las que destacan el desarrollo precoz de síndrome metabólico, diabetes tipo 2 y enfermedad cardiovascular 2 .Las manifestaciones clínicas del SOP son heterogéneas y varían de acuerdo a la edad de la paciente. Se ha propuesto que este trastorno acompañaría a la mujer durante toda la vida, pudiendo manifestarse desde etapas muy tempranas del desarrollo sexual hasta la senectud [3][4][5][6] . El SOP se caracteriza por presentar una morfología ovárica típica con múltiples folículos en crecimiento, aumento del estroma ovárico e hipersecreción de andrógenos, lo que sugiere que las alteraciones de la esteroidogénesis y de la foliculogénesis serían eventos centrales de este

Background: Polycystic ovary syndrome (PCOS) is an endocrine metabolic dysfunction closely associated with insulin resistance and obesity (Rev Méd Chile 2007; 135: 1530-38).