FABP2 Ala54Thr polymorphism and diabetes in Chilean elders

Albala, Cecilia; Villarroel, Ana Claudia; Santos, José Luis; Ángel, Bárbara; Lera, Lydia; Liberman, Claudio; Sánchez, Hugo; Pérez-Bravo, Francisco

doi:10.1016/j.diabres.2006.12.006

Cited by 23 publications

(21 citation statements)

References 30 publications

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“…Fatty acid binding protein 2 is an intracellular protein expressed in small intestine epithelial cells and involved in the metabolism of unsaturated dietary long chain fatty acids [30]. Fatty acid metabolism is well known to be associated with insulin resistance and hence progression to other disorders inicluding obesity, diabetes and cardiovascular diseases [31].…”

Section: Discussionmentioning

confidence: 99%

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The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis

Shabana

Hasnain

2015

Gene

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Section: Discussionmentioning

confidence: 99%

“…There was no heterogeneity among studies (I 2 =38.6%, p-value=0.149) whereas the pooled Odds Ratio was 1.15, CI was 1.02-1 30. …”

mentioning

confidence: 81%

The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis

Shabana

Hasnain

2015

Gene

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“…FABP2 is an intracellular protein expressed in the villus tips of the small intestine, has a high affinity for saturated and unsaturated long-chain fatty acids and is believed to be involved in the absorption and transport of dietary fatty acids [13]. The association between fatty acid metabolism and IR is well known, and the FABP2 gene has been suggested as a possible candidate gene in the development of IR and T2DM [14].…”

Section: Discussionmentioning

confidence: 99%

A54T polymorphism in the fatty acid binding protein 2 studies in a Saudi population with type 2 diabetes mellitus

et al. 2014

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BackgroundFatty acid-binding protein 2 (FABP2) is an intracellular protein expressed exclusively in the enterocytes of proximal small intestine. FABP2 has a high affinity for saturated and unsaturated long-chain fatty acids and is believed to be involved in the absorption and transport of dietary fatty acids.MethodsThis is a case–control study conceded in 438 T2DM cases and 460 subjects with normal glucose levels and non-obese considered as healthy controls. Allelic discrimination was performed using TaqMan single-nucleotide polymorphism was carried out by real time-polymerase chain reaction (RT-PCR) assays using purified DNA.ResultsClinical data and anthropometric measurements except age, glucose levels and lipid profile of the patients were significantly different from those of the controls (p < 0.05). Statistical analyses failed to show any type of significant association of the polymorphism between cases and controls. However logistic regression analyses was suggests that the TT genotype is significantly associated with male patients (p = 0.001). None of the allele or genotypes of FABP2 A54T was associated with T2DM cases versus the controls (AT genotype, OR = 0.85 (0.64-1.12), p = 0.25; TT genotype, OR = 0.66 (0.39-1.11), p = 0.11; T allele, 0.82 (0.67-1.02), p = 0.08).ConclusionIn conclusion, this study suggests that the above named variant in FABP2 gene is not potential contributor to the risk of T2DM and related traits in a Saudi population. However TT genotype is a risk factor for the disease in males.

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“…The FABP2 Ala54Thr gene polymorphism has been suggested as a possible genetic factor associated with insulin resistance and type 2 diabetes [10,11]. However, the results from the published studies on the association of the FABP2 Ala54Thr polymorphism with insulin resistance and blood glucose are conflicting and inconclusive [8][9][10][11][12][13].…”

Section: Discussionmentioning

confidence: 97%

“…FABP2 has a high affinity for saturated and unsaturated long-chain fatty acids and is believed to be involved in the absorption and transport of dietary fatty acids [9]. The association between fatty acid metabolism and insulin resistance is well known, and the FABP2 gene has been suggested as a possible candidate gene in the development of insulin resistance and type 2 diabetes [4,5,10,11]. In 1995, Baier et al reported a G/A mutation (rs1799883).…”

Section: Introductionmentioning

confidence: 98%

Association of the fatty acid‐binding protein 2 gene Ala54Thr polymorphism with insulin resistance and blood glucose: a meta‐analysis in 13451 subjects

Zhao

Yang

2010

Diabetes Metabolism Res

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FABP2 Ala54Thr polymorphism and diabetes in Chilean elders

Cited by 23 publications

References 30 publications

The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis

The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis

A54T polymorphism in the fatty acid binding protein 2 studies in a Saudi population with type 2 diabetes mellitus

Association of the fatty acid‐binding protein 2 gene Ala54Thr polymorphism with insulin resistance and blood glucose: a meta‐analysis in 13451 subjects

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