Improvement of Insulin Resistance and Insulin Secretion by Water Extracts ofCordyceps militaris,Phellinus linteus, andPaecilomyces tenuipesin 90% Pancreatectomized Rats

Choi, Soo Bong; Park, Chun Hee; Mi-Ja, Choi; Jun, Dong Wha; Park, Sunmin

doi:10.1271/bbb.68.2257

Cited by 100 publications

(49 citation statements)

References 27 publications

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“…In contrast to the effect of C. militaris on adipocyte differentiation, its effect on adipocyte hypertrophy might be independent of AhR. Previous reports evidenced antidiabetic effects of C. militaris in pancreatectomized diabetic rats and streptozotocin-induced diabetic mice (8,51). Although the molecular mechanisms involved have not been elucidated, our present results indicate the possibility that the antiadipogenic effect of C. militaris on preadipocytes as well as its antihypertrophic effect on mature adipocytes may, at least in part, explain the antidiabetic effect of this mycelium in vivo.…”

Section: Discussionmentioning

confidence: 96%

“…militaris has been considered an entomopathogenic fungus that may be potentially useful for prevention and treatment of various pathologies in humans including cancers, inflammation, fibrosis, diabetes, and hypercholesterolemia (8,25,27,30,46,47,50). However, in the majority of previous studies only phenomenological evidence was provided, and molecular mechanisms underlying the beneficial, therapeutic effects of C. militaris have never been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies showed that C. militaris inhibits angiogenesis and proliferation of normal and malignant cells (27,47,50). Other investigators also reported the antifibrotic, antidiabetic, antiinflammatory, and hypocholesterolemic potential of this mycelium (8,25,30,46). However, to date, the antiadipogenic potential of C. militaris has never been reported.…”

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confidence: 95%

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Suppression of adipocyte differentiation byCordyceps militaristhrough activation of the aryl hydrocarbon receptor

Shimada¹,

Hiramatsu²,

Kasai³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

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Mycelial extracts have a wide range of biological activities that modulate functions of mammalian cells. In this report, we sought to identify antiadipogenic mycelia with the use of 3T3-L1 cells and found that the extract of Cordyceps militaris exclusively suppressed differentiation of 3T3-L1 preadipocytes into mature adipocytes without affecting cell viability. This inhibitory effect was dose dependent, reversible, and associated with 1) a decrease in lipid accumulation, 2) blunted induction of adipocyte markers including adiponectin, peroxisome proliferator-activated receptor-γ, and CCAAT/enhancer binding protein-α, and 3) sustained expression of a preadipocyte marker, monocyte chemoattractant protein-1. C. militaris also significantly decreased accumulation of lipid and hypertrophy in mature adipocytes and preserved their response to insulin (phosphorylation of Akt) during prolonged culture. Subsequent experiments revealed that C. militaris has the potential to activate the aryl hydrocarbon receptor (AhR). In 3T3-L1 cells, treatment with AhR agonists including benzo[ a]pyrene and 3-methylcholanthrene reproduced the antiadipogenic effect of C. militaris. Furthermore, dominant-negative inhibition of AhR abrogated the suppressive effect of C. militaris on adipocyte differentiation. These results suggest that C. militaris has the potential to interfere with adipocyte differentiation through activation of AhR.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Suppression of adipocyte differentiation byCordyceps militaristhrough activation of the aryl hydrocarbon receptor

Shimada¹,

Hiramatsu²,

Kasai³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

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“…The experiments are repeated thrice using the same protocol. 55 The α-amylase inhibitory activity was calculated by using the formula …”

Section: Assay Of Amylase Inhibitionmentioning

confidence: 99%

Past and Future of in-vitro and in-vivo Animal Models for Diabetes: A Review

Dewangan¹,

Tiwari²,

Sharma³

et al. 2017

IJPER

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Diabetes mellitus is classified into two major types, Type 1 (Insulin Dependent Diabetes Mellitus) and Type 2 (Non-Insulin Dependent Diabetes Mellitus). In world about 90% of diabetes patients are of Type 2 diabetes. There are various in-vivo and in-vitro methods available for the screening of new antidiabetic drugs. In-vivo models mainly uses chemical such as streptozotocin, alloxan etc. for the induction of diabetes where as in-vitro techniques, directly show its effect on cells which are responsible for induction of diabetes in human. In vitro techniques provide more accurate data and possible mechanism which are involved in diabetes disease. Now, a day's newer techniques such as diabetes induction with the help of viruses had been also introduced which are proving to be good tool in evaluation of antidiabetic drugs. This review could prove to be a good tool for the researchers who seek to do research on diabetes as it is providing vast resource about diabetic model under single umbrella.

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“…In China, it has been used as a traditional medicine and health food since ancient times. C. militaris has been reported to have beneficial functional effects such as anti-angiogenesis, 6) anti-tumor, anti-diabetic 7) , and hypoglycemic effects 8) . Cordycepin, a characteristic functional component of C. militaris, has been shown to have anti-inflammatory effects.…”

mentioning

confidence: 99%

Suppressing effect of cordycepin on the lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells

Imamura

Asai

Sugamoto

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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In this study, we focused on the anti-inflammatory effect of cordycepin, 3′-deoxyadenosine. Cordycepin potently suppressed nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells in an adenosine receptor-independent manner. In addition, inhibitors for adenosine kinase and nucleoside transporter abrogated the action of cordycepin. Thus, we considered that intracellular metabolism cordycepin is important for the anti-inflammatory effect of cordycepin.

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Improvement of Insulin Resistance and Insulin Secretion by Water Extracts ofCordyceps militaris,Phellinus linteus, andPaecilomyces tenuipesin 90% Pancreatectomized Rats

Cited by 100 publications

References 27 publications

Suppression of adipocyte differentiation byCordyceps militaristhrough activation of the aryl hydrocarbon receptor

Suppression of adipocyte differentiation byCordyceps militaristhrough activation of the aryl hydrocarbon receptor

Past and Future of in-vitro and in-vivo Animal Models for Diabetes: A Review

Suppressing effect of cordycepin on the lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells

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