“…Operating rooms in the inpatient setting utilized a separate EHR with CPOE (although some orders were still transcribed), but this system did not directly connect to Epic, did not have the CDS capabilities of Epic, and barcoding technologies were not used for all medications administered during procedures. The NCH healthcare network utilized an electronic AE monitoring system where patients, families, and clinicians could enter any ADEs, ADRs, potential ADEs, and medication errors identified during routine care [25]. In addition, an automated trigger tool system was used to detect common medication adverse effects without the need for voluntary reporting (e.g., the use of reversal agents and addition of laxatives for opioid-induced constipation would be automatically collected in the trigger tool database) [7,26].…”