The main purpose of this present study was to investigate the different processing conditions on the microstructure, segregation behavior of alloying elements, and mechanical properties of Al−Mg−Si alloy twin-roll cast slab prepared using a novel twin-roll casting technology. The simulation of temperature field, distribution of alloying elements, tensile properties, hardness, and conductivity were examined by a Leica optical microscope, scanning electron microscopy, energy dispersion spectroscopy, electron probe microanalysis, and tensile tests. The results indicated that when the traditional twin-roll casting method was used to produce aluminum alloy strip, there are obvious centerline segregation defects due to the deep crystallization front depth and symmetrical solidification characteristics. When the forced-cooling technology was applied in the twin-roll casting process, by virtue of the changing of crystallization front depth and crystallization front shape, the segregation defects are obviously suppressed. Suggesting that this method can significantly improve the uniformity of alloying elements in the thickness direction of the twin-roll cast slab, ultimately improve the mechanical properties of AA6022 aluminum alloy.