Improvement of migraine headaches in severely obese patients after bariatric surgery

Bond, Dale S.; Vithiananthan, Sivamainthan; Nash, Justin M.; Thomas, J. Graham; Wing, Rena R.

doi:10.1212/wnl.0b013e318212ab1e

Cited by 89 publications

(74 citation statements)

References 18 publications

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“…The result of this study showed that headache frequency was considerably decreased from before to 6 months post-operatively (11.1 vs. 6.7 headache days), with almost half of subjects demonstrating at least a 50 percent discretion (83,84).…”

Section: The Effect Of Bariatric Surgery On Migraine Headachementioning

confidence: 65%

“…thought, at 6 months after surgery, just 3 (12.5%) of the participants showed this degree of disability. notably, headache improvements occurred post-operatively in spite of that 70% of subjects were still obese, revealing that body weight reduction helps to alleviating headache in the absence of complete improvement of obesity (83).…”

Section: The Effect Of Bariatric Surgery On Migraine Headachementioning

confidence: 97%

“…Later study which was an open, non-controlled, clinical trial of morbid obese subjects admitting for bariatric surgery conducted by Bond et al (83). They evaluated 24 morbid obese, pre-and post-reproductive age patients suffered from episodic migraine.…”

Section: The Effect Of Bariatric Surgery On Migraine Headachementioning

confidence: 99%

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The Effect of Bariatric Surgery on Migraine Headache in Morbid Obese Patients

Hatami

Mohammadi-Farsani

2017

J Minim Invasive Surg Sci

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Background: Migraine is a common and chronic neuro-inflammatory disease with progressive and episodic headache manifestation that leads to considerable disability. Many studies recognized that obesity is a risk factor for progression of migraine. Furthermore, both migraine and obesity is highly prevalent and important risk factors of chronic cardiovascular disease, stroke, and other inflammatory disease. Thus, it is very important if weight loss could alleviate the migraine headache and its related comorbidities. Aim: The present review article was conducted to assess the potential effect of Bariatric surgery on improvement of migraine headaches in morbid obese patients. Search Strategy: Scopus, PubMed and web of science electronic database were systematically searched with key words of "Bariatric surgery", "gastric Bypass"; "Morbid Obesity" and "Migraine headache" for interventional studies investigated the impact of Bariatric surgery on migraine headache. Results: The findings suggest significant improvement in headache frequency, duration, migraine-induced discomfort and migraine derived symptoms (nausea, phono and photophobia and) occurs as early as 3 months after bariatric surgery. Moreover, patients who had higher weight loss were more likely to experience a 50% or higher reduction in headache frequency, duration and severity. Conclusions:The entire evidences suggest patients with indications of bariatric surgery will benefit from the improvements in the Migraine headache after surgery. However, it remains unclear whether Bariatric-induced endocrine, gut-brain axis alterations, or reduction in adipokine contribute to migraine improvement, so further studies are needed to confirm and clarify these findings.

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Section: The Effect Of Bariatric Surgery On Migraine Headachementioning

confidence: 65%

Section: The Effect Of Bariatric Surgery On Migraine Headachementioning

confidence: 97%

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The Effect of Bariatric Surgery on Migraine Headache in Morbid Obese Patients

Hatami

Mohammadi-Farsani

2017

J Minim Invasive Surg Sci

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“…Given the strong association with obesity and migraine chronification [82], nutrition consultant may improve long-term outcomes, especially given recent evidence that long-term weight loss appears to improve migraine severity [83].…”

Section: Discussionmentioning

confidence: 99%

Inpatient Management of Migraine

Marmura

Goldberg

2015

Curr Neurol Neurosci Rep

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“…More specifically, metabolic correction accompanied with lifestyle changes would likely enable a significant proportion of migranieurs to achieve a long-lasting migraine relief without heavily seeking preventive therapies that provide temporary symptomatic relief [12] conducted a review of previous studies on childhood migraine and concluded that restoration of ideal body weight of obese children and adolescents would reduce migraine frequency, use of analgesic therapy and risk of progression to chronic migraine. In another study, [13] conducted bariatric surgery on 24 mostly female obese patients who had persistent severe headache as one of the symptom of their obesity related disease. Significant reduction in headache days as well as severity was reported.…”

Section: Migraine and Metabolic Syndromementioning

confidence: 99%

Metabolic Syndrome in Migraine Patients: Recent Findings and Treatment Approach

Dubey¹

2017

Int J Neurorehabilitation Eng

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The neurovascular theory explains migraine to be a result of complex pathophysiological changes leading to activation of trigeminal nociceptors by several inflammatory mediators. Different classes of drugs have been used to control migraine where specific class of drugs inhibit only specific mediators while sparing others, resulting into suboptimal treatment response. Migraine is also reported by a significant proportion of patients suffering with various metabolic syndrome related conditions. The chronic inflammation caused by metabolic disruptions has been the leading cause that contributes in inducing and worsening migraine attacks. Treating these patients for conditions such as obesity and insulin resistance has resulted in significant improvement in alleviating migraine episodes. These findings provide opportunities to devise a comprehensive migraine treatment regimen that combines pharmacotherapy with metabolic corrections, lifestyle changes and diet therapy to achieve improved treatment outcome. Metabolic Syndrome in Migraine Patients Migraine and Current Treatment OptionsMigraine is the third most prevalent neurological disorder worldwide. As per the latest estimate, US have 38 million migraine patients, with women comprising 85% of them [1]. It is more debilitating than a simple headache due to associated 'aura' like conditions that includes nausea, photophobia or phonophobia. The pathophysiological basis of migraine has been explained in terms of neurological changes originating from hypothalamus and brainstem and spreading to central trigeminovascular neurons where consequent inflammatory pathways release various inflammatory mediators including histamine, prostaglandins, leukotrienes, cytokines and tryptase [2]. These mediators act on pain nociceptors of trigeminovascular system inducing headache. While neurological theory has gained more support recently, vascular theory was once considered as the root cause of the migraine. As per vascular theory, abnormal vasodilation of cranial blood vessels results into release of pain mediators which activate pain nociceptors located on trigeminal nerves that closely follow cranial blood vessels [3]. More recently, research is focused on CGRP as pain mediator. CGRP is a prominent neuropeptide expressed in 35-50% of neurons in the trigeminal ganglia and exert vasodilation effect [4].

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Improvement of migraine headaches in severely obese patients after bariatric surgery

Abstract: Severely obese migraineurs experience marked alleviation of headaches after significant weight reduction via bariatric surgery. Future studies are needed to determine whether more modest, behaviorally produced weight losses can effect similar migraine improvements.

Cited by 89 publications

References 18 publications

The Effect of Bariatric Surgery on Migraine Headache in Morbid Obese Patients

The Effect of Bariatric Surgery on Migraine Headache in Morbid Obese Patients

Inpatient Management of Migraine

Metabolic Syndrome in Migraine Patients: Recent Findings and Treatment Approach

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