Improvement of perineal wound healing by local administration of gentamicin-impregnated collagen fleeces after abdominoperineal excision of rectal cancer

TOPICALLY-USED GENTAMICIN ATTACHED TO NANOFIBRE MDOCTM COMPARED WITH GARAMYCIN SCHWAMM^® IN AN ACUTE WOUND INFECTION MODEL. AN EXPERIMENTAL STUDY.

“…In total, bacteriologic efficacy amounted to 83.7 % in the treated group vs. 60.4 % in controls. The difference in infection rates was significant as well, 6 % vs. 20.8 % [19]. Similar results were reported in the studies of Rosen et al and Gomez et al -though with a significantly higher percent of primary wound healing in the gentamicin group, 87 % vs. control 46 %, and rate of infections in 9 % vs. 44 %, respectively [20][21].…”

“…Haase et al did not show any differential effect between topically-subcutaneouslyused gentamicin implants with regard to the prevention of wound infections after loop-ileostomy closure [18]. However, very good results with topical administration of gentamicin were achieved in more randomized controlled studies [19][20][21]. Grüssner et al found a reduction of pathogens in cultures and a lower infection rate in perineal wounds after abdominoperineal excisions.…”

Randomized clinical trial of local gentamicin–collagen treatment in advancement flap repair for anal fistula

“…Schouten et al 20 found that patients with more than one previous fistula repair had significantly higher recurrence rates than those with one or no previous repair (50 versus 13 per cent respectively), but in a later study by the same group there was no difference 18 . In other studies, in which the proportion of patients with previous repairs varied between 15 and 47 per cent, earlier repair had no impact on the recurrence rate 3,9 -11 . The use of a draining seton before advancement flap repair resulted in lower recurrence rate in a study by Sonoda et al 9 , whereas Zimmerman et al 18 noted that this practice made no difference.…”

“…Local application of gentamicin-collagen has been used both to prevent and treat surgical wound infection 12 -14 . This treatment has been demonstrated to improve perineal wound healing after abdominoperineal excision of rectal cancer 15 and to reduce postoperative complications after rectal cancer surgery 16 . The primary aim of the present study was to evaluate whether local antibiotic treatment with gentamicin-collagen improves healing after endoanal advancement flap repair for anal fistula.…”

Pedicled vastus lateralis musculofascial flap as a new technique for repairing rectourethral fistula after radical prostatectomy

“…Meanwhile, it was reported that the use of local antibiotics of gentamicin reduced the incidence of postoperative perineal and sacral infections after abdominoperineal resection, 14 so the use of gentamicin should be indicated for the future patients.…”