Improvement of quality of life and menopausal symptoms in climacteric women treated with low-dose monthly parenteral formulations of non-polymeric microspheres of 17<b>β</b>-estradiol/progesterone

Cortés-Bonilla, Manuel; Alonso-Campero, Rosalba; Bernardo-Escudero, Roberto; Francisco-Doce, María Teresa de Jesús; Chavarín-González, Juan; Pérez‐Cuevas, Ricardo; Chedraui, Peter

doi:10.1080/09513590.2016.1183628

Cited by 6 publications

(8 citation statements)

References 19 publications

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“…Later was presented the short-term effect of the same proposed schemes over secondary endpoints (menopausal symptoms and QoL). After 6 months, there was an improvement of menopausal symptoms for all groups [26].…”

Section: Quality Of Life and Menopausementioning

confidence: 85%

Quality of Life and Menopause

Velasco-Téllez¹,

Cortés-Bonilla²,

Ortiz-Luna³

et al. 2020

Quality of Life - Biopsychosocial Perspectives

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Since the middle of twentieth century, the concept of Quality of Life (QoL) has been a point of interest for many investigators and clinicians for different health and physiological issues. Menopause has not been an exemption of this, due to the increase of the life expectation, the importance of Women's Health and the view of this period of life as important as the reproductive one. Many of us work, trying to offer these women with treatments, health solutions, and psychological tools to embrace and enjoy this new chapter in her life. In this chapter, we present a review of the QoL studies on this period and the new trends on treatments and help for these women on health problems, their mental and sexual well-being.

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Section: Quality Of Life and Menopausementioning

confidence: 85%

Quality of Life and Menopause

Velasco-Téllez¹,

Cortés-Bonilla²,

Ortiz-Luna³

et al. 2020

Quality of Life - Biopsychosocial Perspectives

Self Cite

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“…The analysis of articles identified the MENQOL (Ghazanfarpour et al, 2013) as the most commonly used rating scale assessing the symptoms and quality of life of menopausal women. Furthermore, other specific rating scales, such as the Greene Climacteric Scale (Cortés-Bonilla et al, 2016), the KI (Capistrano et al, 2015), the MENQOL (Vora, Dangi, 2014), the WHQ (Hunter, 2003), and the UQoLS (Cortés-Bonilla et al, 2016), were mentioned in association with the problem of quality of life in this important and demanding stage of women's lives. In addition to these tools, rating scales intended for use in a general population were mentioned, namely the Pittsburgh Sleep Quality Index (Taavoni et al, 2014), WHOQL-BREF (Kim et al, 2018), Quality of Life Enjoyment Scale questionnaire, the Sheehan Disability Scale, and the Social Adjustment Scale (Wariso et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

“…Other studies were concerned with the urogenital system (Di Bonaventura et al, 2014;Eftekhar et al, 2016), the psychology of women (Da Silva, dʼAndretta Tanaka, 2013;Wariso el al., 2017), and comparison of symptoms in women from different cultures (Vural, Yangin, 2017). In addition, studies focusing on the methods of substitutional hormonal treatment (Cortés-Bonilla et al, 2016), and on the importance of women's education and readiness to embrace climacteric changes (Urbánková, Moravcová, Dopitová, 2016) were found. Based on the literature search and content analysis of studies published in scientific databases, the MRS was identified as the most commonly used tool to assess symptoms and changes in climacteric women (both in the CR and abroad), alongside other, less frequently used measuring scales.…”

Section: Discussionmentioning

confidence: 99%

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Use of evaluation tools to evaluate symptoms and changes in climacteric women in the Czech Republic and abroad

Belešová¹,

Tóthová²

2019

Cent Eur J Nurs Midw

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Aim: The paper surveys empirical research on the use of evaluation tools with the purpose of evaluating symptoms and changes in climacteric women in the Czech Republic and other countries. In order to evaluate the range of individual symptoms, a great number of standardized questionnaires and measuring scales have been created, which are logically designed for clear statistic evaluation, and are used on a global scale to measure the severity of disorders, or quality of life of women. Design: A literature review. Methods: In outline, the article is an overview making use of content analysis of studies published in scientific databases, e.g. EBSCO, PubMed, ProQuest, and ScienceDirect, during the years 2012 to 2018. The overview focuses on articles dealing with the use of evaluation tools in connection with menopause. After screening for eligibility, 25 articles were eventually analyzed. Results: Following analysis of the results of foreign empirical research, it was apparent that the most common evaluation tool for defining the types and level of symptoms in climacteric women was the Menopausal Rating Scale. Besides this tool, other tools, such as the Greene Climacteric Scale, the Kuperrman index, the Menopause-Specific Quality of Life Questionnaire, the Womenʼs Health Questionnaire, and the Utian Quality of life Scale were used in this field. Two studies focusing on the Czech Republic were analyzed. The standardized tool used in these cases was the Menopausal Rating Scale. Conclusion: A number of foreign studies have been conducted regarding climacteric women monitoring symptoms and changes in psychological condition and behaviour, and changes in their cognitive and emotional states, or evaluating their quality of life. However, only two such studies have been undertaken in the Czech Republic.

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“…While the therapeutic efficacy of hormonal therapies has been proven, their use has declined due to perceived and real, safety concerns. It should be a convenient, effective, and low dose product that also addresses the safety concerns relevant to healthy women undergoing menopause [10].…”

Section: Traditional Remedies: Herbal Teas Dietary Measures Etcmentioning

confidence: 99%

Non-polymeric Microspheres for the Therapeutic Use of Estrogens: An Innovative Technology

Sosa¹,

Fuentes²,

Rico³

et al. 2019

Estrogen

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Non-polymeric microspheres are stable-shaped particles constituted by crystalline organic compounds. This technology allows controlled release of parental products that has its prime value on estrogen therapy. The structure is a nonpolymeric crystalline microsphere that uses a low solubility fatty acid, cholesterol as a carrier. Cholesterol is a waxy lipid, a substance that is insoluble in water and has been recognized as safe as excipient by FDA for the manufacturing of drugs. Cholesterol is a lipid present in the cell membrane and subcellular organelles of tissues and serves as the building block for all steroid hormones including cortisol, aldosterone, estrogen, and testosterone; therefore, this fatty acid provides better biocompatibility than polymers. The use of cholesterol as a low solubility carrier was used to develop a first of its kind, parental HT product for the management of menopausal symptoms carrying estrogen microspheres in an aqueous suspension, which would allow an extended estrogen release maintaining plasmatic therapeutic concentrations. Estradiol doses would be up to 30 times lower than that provided by oral and transdermal routes fulfilling current recommendations regarding the use of a low dose and the nonoral route. Both intramuscular monthly administered formulations of E/P non-polymeric microspheres had favorable pharmacokinetic and safety profiles, suggesting this route as an interesting, novel, and suitable way of treating menopause-related symptoms.

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Improvement of quality of life and menopausal symptoms in climacteric women treated with low-dose monthly parenteral formulations of non-polymeric microspheres of 17β-estradiol/progesterone

Abstract: Clinicaltrials.gov Identifiers NCT 00775242.

Cited by 6 publications

References 19 publications

Quality of Life and Menopause

Quality of Life and Menopause

Use of evaluation tools to evaluate symptoms and changes in climacteric women in the Czech Republic and abroad

Non-polymeric Microspheres for the Therapeutic Use of Estrogens: An Innovative Technology

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