Improvement of speed of separation in packed column gas chromatography

Jonker, R.J.; Poppe, H.; Huber, J.F.K.

doi:10.1021/ac00251a011

Cited by 49 publications

(24 citation statements)

References 36 publications

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“…The suitability of SGSC for the selective separation of unsaturated compounds was further investigated by separating C hydrocarbons on columns 6 containing porous silica particles under isothermal Ž . Ž .…”

Section: Resultsmentioning

confidence: 99%

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Solvating gas-solid chromatography

Shen¹,

Lee²

1999

J. Micro. Sep.

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Capillary columns containing microparticulate adsorbents were used with CO2 as the mobile phase. By operating at selected temperatures, the CO2 mobile phase changed from liquid or supercritical fluid to gas between the column inlet and outlet. The column efficiency was examined for both situations. Similar minimum‐reduced plate heights (h∼1.5) were obtained for both situations, however, higher optimum mobile phase linear velocity (uopt) was observed when using a mobile phase that changed from supercritical fluid to gas than from liquid to gas. Silica and alumina adsorbents provided high selectivities for unsaturated (olefinic and aromatic) hydrocarbons. Silica adsorbents were more suitable than alumina for the separation of highly unsaturated compounds such as aromatic compounds, while alumina‐packed capillary columns yielded lower resistance to CO2 mobile phase flow and allowed faster separations. Chromatographic separations can be optimized by combining various modes of chromatography [i.e., liquid chromatography (LC), supercritical fluid chromatography (SFC), and gas chromatography (GC)] along the column length. ©1999 John Wiley & Sons, Inc. J Micro Sep 11: 359–365, 1999

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Section: Resultsmentioning

confidence: 99%

“…and isobaric conditions. Figures 4 A ᎐ C shows SGSC separations of C hydrocarbons according to 6 number, cisrtrans structure, and position of double Ž . bond s using a mobile phase that changes from a Ž .…”

Section: Resultsmentioning

confidence: 99%

Solvating gas-solid chromatography

Shen¹,

Lee²

1999

J. Micro. Sep.

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“…Table 10.1 shows two of the fastest separations ever accomplished using packed capillary and narrow bore capillary GC [94], [95]. It is useful to look at these two examples and to make the following observations:…”

Section: Fundamental Tradeoffsmentioning

confidence: 99%

Sample extraction and injection with a microscale preconcentrator.

Robinson

Chan²

2007

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This report details the development of a microfabricated preconcentrator that functions as a fully integrated chemical extractor-injector for a microscale gas chromatograph (GC). The device enables parts-per-billion detection and quantitative analysis of volatile organic compounds (VOCs) in indoor air with size and power advantages over macro-scale systems. The 44 mm 3 preconcentrator extracts VOCs using highly adsorptive, granular forms of graphitized carbon black and carbon molecular sieves. The micron-sized silicon cavities have integrated heating and temperature sensing allowing low power, yet rapid heating to thermally desorb the collected VOCs (GC injection). The keys to device construction are a new adsorbent-solvent filling technique and solvent-tolerant wafer-level silicon-gold eutectic bonding technology. The product is the first granular adsorbent preconcentrator integrated at the wafer level. Other advantages include exhaustive VOC extraction and injection peak widths an order of magnitude narrower than predecessor prototypes. A mass transfer model, the first for any microscale preconcentrator, is developed to describe both adsorption and desorption behaviors. The physically intuitive model uses implicit and explicit finite differences to numerically solve the required partial differential equations. The model is applied to the adsorption and desorption of decane at various concentrations to extract Langmuir adsorption isotherm parameters from effluent curve measurements where properties are unknown a priori.

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“…The normal inside diameter of a capillary column is approximately 250 ,um, but recently columns with diameters of 50 ,um and below have been prepared. Work by Schutjes et al (5) has demonstrated separation of roughly 100 hydrocarbon components from a plant extract in only 6 minutes. These columns require somewhat higher carrier gas pressures than ordinary capillaries and place greater demands on sample injections, system dead volumes, and detector sensitivity and speed.…”

Section: Gas Chromatographymentioning

confidence: 99%

Trends in Analytical Scale Separations

Jorgenson

1984

Science

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Although gas chromatography has been called a mature technology, advances are still being made in the development of faster columns as well as detectors which yield more information on solutes. In liquid chromatography short columns packed with 3-micrometer particles are already popular for fast analyses, while long narrow-bore columns are being developed for high-resolution separations. An increasing range of detection modes is enhancing the problem-solving capabilities of liquid chromatography. Electrophoresis continues to be of central importance to molecular biology. Computer-aided analysis and display of electropherogram patterns is helping researchers to better comprehend the wealth of data from two-dimensional electrophoresis. A new mode of two-dimensional electrophoresis is permitting separation of whole chromosomes containing as many as 3 million base pairs.

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Improvement of speed of separation in packed column gas chromatography

Cited by 49 publications

References 36 publications

Solvating gas-solid chromatography

Solvating gas-solid chromatography

Sample extraction and injection with a microscale preconcentrator.

Trends in Analytical Scale Separations

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