Improvement of Stability and Transdermal Delivery of Bioactive Compounds in Green Robusta Coffee Beans Extract Loaded Nanostructured Lipid Carriers

Nitthikan, Nichcha; Leelapornpisid, Pimporn; Natakankitkul, Surapol; Chaiyana, Wantida; Mueller, Monika; Viernstein, Helmut; Kiattisin, Kanokwan

doi:10.1155/2018/7865024

Cited by 22 publications

(21 citation statements)

References 32 publications

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“…In contrast, Boelzinger et al showed greater penetration of ChA from microemulsion than from the gel or emulsion [ 65 ]. However, an increase of CA penetration was observed through the pig ear after using liposomes [ 66 ] and nanostructured lipid carriers [ 67 ]. The same substances in different vehicles may penetrate deeper or accumulate in greater amounts in the skin.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Human Skin Penetration, Antioxidant and Antimicrobial Activity of Ethanol-Water Extract of Fireweed (Epilobium angustifolium L.)

et al. 2021

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Epilobium angustifolium L. is applied as an antiseptic agent in the treatment of skin diseases. However, there is a lack of information on human skin penetration of active ingredients with antioxidative potential. It seems crucial because bacterial infections of skin and subcutaneous tissue are common and partly depend on oxidative stress. Therefore, we evaluated in vitro human skin penetration of fireweed ethanol-water extracts (FEEs) by determining antioxidant activity of these extracts before and after penetration study using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and Folin–Ciocalteu methods. Microbiological tests of extracts were done. The qualitative and quantitative evaluation was performed using gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC-UV) methods. The in vitro human skin penetration using the Franz diffusion chamber was assessed. The high antioxidant activity of FEEs was found. Gallic acid (GA), chlorogenic acid (ChA), 3,4-dihydroxybenzoic acid (3,4-DHB), 4-hydroxybenzoic acid (4-HB), and caffeic acid (CA) were identified in the extracts. The antibacterial activities were found against Serratia lutea, S. marcescens, Bacillus subtilis, B. pseudomycoides, and B. thuringiensis and next Enterococcus faecalis, E. faecium, Streptococcus pneumoniae, Pseudomonas aeruginosa, and P. fluorescens strains. In vitro penetration studies showed the penetration of some phenolic acids and their accumulation in the skin. Our results confirm the importance of skin penetration studies to guarantee the efficacy of formulations containing E. angustifolium extracts.

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Section: Discussionmentioning

confidence: 99%

In Vitro Human Skin Penetration, Antioxidant and Antimicrobial Activity of Ethanol-Water Extract of Fireweed (Epilobium angustifolium L.)

et al. 2021

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“…14 Required HLB (rHLB) plays an important role while selecting suitable type and amount of surfactant for NLC formulation. 16 rHLB of lipids and lipid matrix is determined to calculate the amount of emulsifiers to be added in formulation. The rHLB value for lipid is the HLB value of emulsifier which is necessary for appropriate emulsification i.e.…”

Section: Surfactantsmentioning

confidence: 99%

“…The mixture is put through high pressure homogenization and analyzed for least particle size. 16,18,19 Other ingredients Organic salts and ionic polymers may be employed as counter-ions in formulation of nano structure carriers to overcome the challenge of encapsulating water soluble drug molecules. Surface-modifiers are another category of excipients used in formulation of NLC to minimize their phagocytic uptake by the macrophages in reticuloendothelial system (RES).…”

Section: Surfactantsmentioning

confidence: 99%

Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery

Chauhan¹,

Yasir

Verma³

et al. 2020

Adv Pharm Bull

293

145

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Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and co-surfactants. Over time, as a second generation lipid nanocarrier NLC has emerged as an alternative to first generation nanoparticles. This review article highlights the structure, composition, various formulation methodologies, and characterization of NLCs which are prerequisites in formulating a stable drug delivery system. NLCs hold an eminent potential in pharmaceuticals and cosmetics market because of extensive beneficial effects like skin hydration, occlusion, enhanced bioavailability, and skin targeting. This article aims to evoke an interest in the current state of art NLC by discussing their promising assistance in topical drug delivery system. The key attributes of NLC that make them a promising drug delivery system are ease of preparation, biocompatibility, the feasibility of scale up, non-toxicity, improved drug loading, and stability.

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“…The particle size, polydispersity index (PDI), and zeta potential of unloaded NLCs were measured by Zetasizer (Zetasizer ® ZS, Malvern Instruments Ltd., UK). Each formulation was diluted at a ratio of 1:100 with deionized water and then the diluted sample was measured the particle size and polydispersity index (PDI) at room temperature (25 ± 0.5°C) with the detection angle of 173° (Nitthikan et al., 2018). The measurement was performed in triplicate.…”

Section: Methodsmentioning

confidence: 99%

Stability enhancement of lycopene in Citrullus lanatus extract via nanostructured lipid carriers

Sirikhet

Chanmahasathien

Raiwa

et al. 2021

Food Science & Nutrition

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Lycopene is one of naturally occurring carotenoids in plants including watermelon (Citrullus lanatus). Heat, light, and oxygen effect on lycopene isomerization and degradation. Nanostructured lipid carriers (NLCs) are drug delivery system which can enhance the stability of active compound. Therefore, this study aimed to develop watermelon extract loaded in NLCs for lycopene stability improvement. The NLCs were prepared using a hot homogenization technique. Cocoa butter was used as solid lipid. Grape seed oil was used as liquid lipid. Span® 80 and Plantasens® HE20 were used as an emulsifier. The selected unloaded NLCs contained solid lipid to liquid lipid at the ratio of 3:1 and 10% (w/w) of total lipid. The particle size of watermelon extract‐loaded NLCs (WH‐loaded NLCs) was 130.17 ± 0.72 nm with low PDI and high zeta potential. It also presented high entrapment efficiency. For stability study, the WH‐NLC3 could enhance stability and maintain lycopene content after stability test. It exhibited the highest values of lycopene content (83.26 ± 2.30%) when stored at 4°C. It also possessed a prolonged release pattern over 48 hr. Therefore, the NLCs could improve stability and release profile of lycopene from watermelon extract.

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Improvement of Stability and Transdermal Delivery of Bioactive Compounds in Green Robusta Coffee Beans Extract Loaded Nanostructured Lipid Carriers

Cited by 22 publications

References 32 publications

In Vitro Human Skin Penetration, Antioxidant and Antimicrobial Activity of Ethanol-Water Extract of Fireweed (Epilobium angustifolium L.)

In Vitro Human Skin Penetration, Antioxidant and Antimicrobial Activity of Ethanol-Water Extract of Fireweed (Epilobium angustifolium L.)

Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery

Stability enhancement of lycopene in Citrullus lanatus extract via nanostructured lipid carriers

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