Improvement of the extraction efficiency of d-amygdalin from Armeniacae Semen powder through inactivating emulsin and suppressing the epimerization of d-amygdalin

Kwon, Ha-Jeong; Lee, Je-Hyun; Hong, Seon-Pyo

doi:10.1007/s12272-010-2229-3

Cited by 11 publications

(4 citation statements)

References 11 publications

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“…Regardless of the increase of dose and exposure time, BCG-PSAW and BCG-PSN had no significant effect on C666-1. In details, there was a little tumor inhibition was obtained with BCG-PSAW and BCG-PSN, and the inhibition ratio of this two samples was only 27.3% and 11.25%, respectively, in a dose of 400 g/mL after 72 h. These results suggested that the antitumor activities of BCG-PSAW and BCG-PSN might be based on its immunostimulation function rather than a direct cytocidal effect on the tumor cells more or less, which was consistent with the previous references (Kwon, Lee, & Hong, 2010;Chang & Zhang, 2012).…”

Section: Antitumor Activity (Mts Assay)supporting

confidence: 90%

Purification and characterization of a glucan from Bacillus Calmette Guerin and the antitumor activity of its sulfated derivative

Shao

et al. 2015

Carbohydrate Polymers

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Section: Antitumor Activity (Mts Assay)supporting

confidence: 90%

Purification and characterization of a glucan from Bacillus Calmette Guerin and the antitumor activity of its sulfated derivative

Shao

et al. 2015

Carbohydrate Polymers

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“…Chang et al (2006) stated that despite the significant effects of AMG, the Food and Drug Administration (FDA) has not approved it in cancer treatment owing to insufficient clinical evidence of efficacy and potential toxicity of AMG. Despite the failure of clinical tests to demonstrate the anticancer effects of AMG in the USA and in Europe, it continues to be manufactured and administered as an anticancer therapy in northern Europe and Mexico (Chang et al, 2006;Kwon et al, 2010). The effect of AMG is generally known in the treatment of cancer.…”

Section: Figurementioning

confidence: 99%

The Effect of Apricot Seeds on Microscopic Structure of Rabbit Liver

Kolesárová¹,

Džurňáková²,

Michalcová³

et al. 2020

J microb biotech food sci

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Natural phytosubstances, such as amygdalin, used in alternative medicine has gained popularity. However, some researchers suspect the protective properties of amygdalin due to a lack of clinical studies. The aim of the present in vivo study was to determine the effect of apricot seed administration on microscopic changes in the liver using a rabbit as a biological model. Sixteen male rabbits 45 days old were randomly divided into four groups (control group without any apricot seed administration, and experimental groups fed by crushed apricot seeds at the doses 60, 300 and 420 mg/kg b.w., mixed with commercial feed), which was administered orally a daily during a ten-month period. The liver tissue samples were evaluated by histological analysis. Significant changes were observed in the microscopic structure of rabbit livers after apricot seed ingestion. The morphometric evaluation of rabbit livers after the application of apricot seeds showed an increase of binucleated cells in the vena centralis region (P≤0.001) at the highest dose and in the peripheral zone at all the doses used (P≤0.001, P≤0.01, P≤0.05) compared to control. On the other hand, distinct inhibition in the number of binucleated cells in the region vena centralis at the doses 300 (P≤0.01) and 420 mg/kg b.w. (P≤0.05) and in the peripheral zone at all the doses used (P≤0.001, P≤0.01) was observed. No significant differences between the control and experimental groups in vena centralis after apricot seed treatment were found (P≥0.05). In addition, the effect of apricot seeds on the relative volume of liver structures – vena centralis, stroma and parenchyma after the application of apricot seeds to rabbit males were assessed. No significant differences between control and experimental groups in the relative volume of vena centralis were found (P≥0.05). On the other hand, the relative volume of the stroma was increased at doses 60 (P≤0.05) and 300 (P≤0.01) mg/kg b.w. Interestingly, the relative volume of parenchyma was significantly decreased (P≤0.05) after the application of apricot seeds in two experimental groups 60 and 300 mg/kg b.w. The current study provides experimental evidence that apricot seeds might affect the liver microscopic structure in rabbits in vivo and thus amygdalin present in apricot seeds might present a potential risk for animal health. However, the toxic effect could not be accurately corroborated, as in many cases changes were dose-dependent and not recorded at the highest dose used in the study.

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“…Amygdalin, can be used for an effective prevention and treatment of human cancer (Gomez et al, 1998). However, the Food and Drug Administration (FDA) has not approved amygdalin as a cancer treatment owing to insufficient clinical evidence of its efficacy and potential toxicity (Chang et al, 2006;Kwon et al, 2010). The seed oil has been used to treat tumors, ulcers (Rieger, 2006) well as in cosmetics and as a pharmaceutical agent (laxative and expectorant).…”

Section: Introductionmentioning

confidence: 99%

Blood plasma levels of anterior pituitary hormones of rabbits after apricot seed exposure in vivo

Michalcová¹,

Halenár²,

Tušimová³

et al. 2016

j. cent. eur. agric.

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The present study describes possible changes in plasma levels of anterior pituitary hormones induced by bitter apricot (Prunus armeniaca L.) seeds in young female rabbits in vivo. Prunus armeniaca L. is an important medicinal edible plant species commonly known as "apricot". The apricot is a member of the Rosaceae and subfamily Prunoideae. It is one of the most delicious and commercially traded fruits in the world. Apricot kernel is the inner part of the seed of the apricot fruit. The kernel is used to produce oil and other chemicals used for medicinal purposes. The seeds are potentially useful in human nutrition and for treatment several diseases especially cancer. In the present study apricot seeds were mixed with feed at different doses 0, 60, 300, 420 mg*kg -1 of body weight. ELISA was used to determine the levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL). 58-days application of apricot seeds did not affect the concentration (P≥0.05) of PRL, LH in blood plasma. Significant (P≤0.01) inhibition of FSH levels induced by the seeds was found at the dose of 420 mg*kg -1 but not at 60 and 300 mg*kg -1 of body weight. These results are suggesting that the natural substances present in apricot seeds may be involved in mechanisms of ovarian folliculogenesis. AbstraktTáto štúdia popisuje možnú zmenu koncentrácie hormónov adenohypofýzy u mladých samíc králikov, vyvolanú biologickou aktivitou horkých marhuľových semien (Prunus armeniaca L.). Prunus armeniaca L. je jedlý liečivý druh všeobecne známy ako "marhuľa". Marhuľa obyčajná patrí do čeľade Rosaceae a podčeľade Prunoideae. Reprezentuje jedno z najchutnejších a komerčne ľahko dostupných ovocných druhov na svetovom trhu. Marhuľové semeno je vnútorná časť jadra marhúľ. Semeno sa využíva na výrobu oleja a iných chemických zlúčenín, ktoré našli uplatnenie v medicíne. Semená sú potenciálne vhodné pre ľudskú výživu a na liečbu mnohých ochorení najmä nádorov. V predloženej štúdii boli marhuľové semená pridané do krmiva v rôznych dávkach 0, 60, 300, 420 mg*kg -1 telesnej hmotnosti. Následne bola na stanovenie folikulostimulačného (FSH), luteinizačného hormónu (LH) a prolaktínu (PRL) použitá ELISA metóda. 58-dňová aplikácia marhuľových semien nemala vplyv (P≥0.05) na koncentráciu PRL, LH v krvnej plazme. Významná (P≤0.01) inhibícia uvoľňovania FSH bola indukovaná pri dávke 420 mg*kg -1 živej hmotnosti marhuľových semien. Tieto výsledky naznačujú, že prírodné látky prítomné v semenách marhúľ, by mohli byť zapojené do mechanizmov ovariálnej folikulogenézy.

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Improvement of the extraction efficiency of d-amygdalin from Armeniacae Semen powder through inactivating emulsin and suppressing the epimerization of d-amygdalin

Cited by 11 publications

References 11 publications

Purification and characterization of a glucan from Bacillus Calmette Guerin and the antitumor activity of its sulfated derivative

Purification and characterization of a glucan from Bacillus Calmette Guerin and the antitumor activity of its sulfated derivative

The Effect of Apricot Seeds on Microscopic Structure of Rabbit Liver

Blood plasma levels of anterior pituitary hormones of rabbits after apricot seed exposure in vivo

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