Improvement of the gelling ability in restructured fish products: effect of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide level and pH

Cardoso, Carlos; Ribeiro, Bernardete; Mendes, Rogério

doi:10.1007/s00217-012-1713-z

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…DCC and DIC exhibit dermal toxicity and carcinogenic activity in tests using mice (Hayes et al, 1998; Kato et al, 2002; Surh et al, 2012). Currently, EDC is considered to have low toxicity and is used more extensively than DCC and DIC, including in synthesis of medical and food‐grade polymers (Cardoso et al, 2012; Park et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Effects of polycaprolactone degradation products on the water flea, Daphnia magna: Carbodiimide additives have acute and chronic toxicity

Matsumoto

Ito

Tateishi

et al. 2023

J of Applied Toxicology

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Plastics have benefited our lives in many ways, but their long persistence in the environment causes serious problems. Rapid decomposition and detoxification of plastics after use are significant challenges. As a possible solution, biodegradable plastics have attracted attention, and for environmental risk assessment research on polymer toxicity, use of indicator organisms, like water fleas and fish, has increased globally. However, such research often focuses on standardized substances without considering changes in toxicity due to plastic degradation products. Additionally, tests generally focus on acute toxicity, while long‐term effects on organismal reproduction and lifespan are largely unknown. Understanding the impact of degraded polymers on biological activities is crucial for accurate risk assessment. In this study, we investigated the biological toxicity of substances generated during degradation of polycaprolactone (PCL), a common biodegradable plastic, using the indicator organism, Daphnia magna. We examined PCL, oligocaprolactones (OCLs), and monomers resulting from polymer cleavage, as well as carbodiimides, added during polyester synthesis. As a result, PCL, which is insoluble in water, reduced individual survival and total number of offspring at an exposure concentration of 100 mg/L, while no toxicity was observed for water‐soluble degradation products, OCLs, and monomers. Furthermore, carbodiimides, which are expected to be released during PCL degradation, showed strong toxicity, significantly reducing individual survival and total number of offspring at 0.1–10 mg/L. These findings suggest that changes in physical properties due to polymer degradation and release of additives can significantly alter their toxicity.

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