2012
DOI: 10.1111/apha.12043
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Improvement of the metabolic status recovers cardiac potassium channel synthesis in experimental diabetes

Abstract: Diabetes reduces K(+) current densities in ventricular myocytes due to a defect in channel protein synthesis. Activation of AMP-K secondary to deterioration in the metabolic status of the cells is responsible for K(+) channel reductions.

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Cited by 31 publications
(34 citation statements)
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“…, , Torres‐Jacome et al . ). Further, the rabbit model has been widely used for studying sustained arrhythmias and ventricular fibrillation (VF) (Such et al .…”
mentioning
confidence: 97%
“…, , Torres‐Jacome et al . ). Further, the rabbit model has been widely used for studying sustained arrhythmias and ventricular fibrillation (VF) (Such et al .…”
mentioning
confidence: 97%
“…The pathology of the cardiac system induced by diabetes includes interstitial fibrosis, imbalance of cardiac ionic currents, apoptosis of cardiomyocytes, abnormal energy use and cardiac neuropathy. Moreover, diabetes can cause severe vascular defects, leading to micro-and macroangiopathy (McVeigh et al 1992, Casis et al 2000, Aragno et al 2008, Torres-Jacome et al 2013. However, the mechanisms of this pathology are not entirely understood.…”
Section: Diabetic Cardiomyopathy and Mirnasmentioning
confidence: 99%
“…Abnormalities of glucose and insulin result in hyperglycemia, together with dysregulation of carbohydrate, fat and protein metabolism. Severe complications, including retinopathy (3), nephropathy (4,5) and cardiovascular disease (6,7), contribute to the deleterious consequences of T2DM. Although the progression of clinical complications of T2DM can be prevented or delayed by effective glycemic control (8), the current medical management for T2DM may yield unsatisfactory results due to the lack of comprehensive awareness with regards to the physiological basis of T2DM.…”
Section: Introductionmentioning
confidence: 99%