Improvement of the microstructure and mechanical properties of bioceramic scaffolds using electrohydrodynamic spraying with template modification

Muthutantri, Anushini; Edirisinghe, Mohan; Boccaccını, Aldo R.

doi:10.1016/j.jmbbm.2009.10.004

Cited by 10 publications

(1 citation statement)

References 24 publications

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“…The compressive strength values of the scaffold groups examined (Fig. 14) fall within the range of cancellous bone (2-12 MPa) (Muthutantri et al, 2010), suggesting that they are appropriate for use in bone tissue engineering applications in places that do not sustain loads.…”

Section: Discussionmentioning

confidence: 80%

An in vitro evaluation of the biological activity of biogenic eggshell-derived nanosized bioglass, poly (ε-caprolactone), and zein protein 3D composite scaffolds for bone tissue engineering

El-Korashy,

El-Shahidy,

Badawy

et al. 2024

Catrina: The International Journal of Environmental Sciences

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Applying biologically active scaffolds to promote bone tissue regeneration and reduce environmental pollution caused by biological waste are the main goals of this study. Sol-gel methods were utilized in this study to create nano-sized bioactive glass ceramics, which are frequently used as graft material or bone filler. Two synthesis routes were compared: one utilizing pure chemicals and the other utilizing biogenic CaCO 3 sourced from eggshell waste as an innovative approach. X-ray diffraction and Fourier transform infrared analyses showed that both bioglass powders consisted of amorphous phases with particle sizes of crystals measuring 14-16 nm, as observed through transmission electron microscopy. Upon immersion in phosphatebuffered saline, carbonate apatite crystals were observed to develop on the surfaces of solid bioglass and composite polymeric scaffolds composed of polycaprolactone/zein protein. These porous and non-toxic scaffolds facilitated osteoblast attachment, proliferation, and differentiation. The incorporation of bioglass enhanced mechanical properties, rates of biodegradation, and cell behavior. Incorporating biogenic bioglass powder into the PCL/Zein scaffold matrix improved the thermal stability of the synthesized scaffolds. Biogenic bioglass contributed to the bioactivity, degradation rate, viability, and calcium deposition of bone marrow Mesenchymal stem cells (r-BMMSC) to a certain extent. This study explores the utilization of eggshell waste as a costeffective source of calcium for Nano-bioglass synthesis. The resulting nano-bioglass was incorporated into 3D PCL/Zein composite scaffolds for bone tissue engineering in non-loadbearing areas. Furthermore, the study suggests the application of biogenic bioglass in dentistry for oral care product fabrication due to its superior bioactivity compared to chemically synthesized bioglass.

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Section: Discussionmentioning

confidence: 80%