Seismic isolation systems have been used worldwide in bridge structures to reduce vibration and avoid collapse. The seismic isolator, damper, and Shock Transmission Unit (SUT) are generally adopted in the seismic design of bridges to improve their seismic safety with economic efficiency. There are several seismic isolation systems, such as Natural Rubber Bearing (NRB), Lead Rubber Bearing (LRB), and the Eradi-Quake System (EQS). EQS as a new technology is expected to effectively reduce both seismic force and displacement, but there is still some need to verify whether it might provide an economical and practical strategy for a bridge isolation system. Moreover, it is important to guarantee consistent performance of the isolators by quality control. A comparative evaluation of the basic properties of the available seismic isolators is thus necessary to achieve a balance between cost-effectiveness and the desired performance of the bridge subjected to extreme loading. Accordingly, in this study, the seismic response characteristics of the seismic isolation systems for bridges were investigated by conducting compressive test and compressive-shear test on NRB, LRB, and EQS.