Improvement predictors in obsessive-compulsive disorder. An event-related potential study

Morault, P; Guillem, François; Bourgeois, M; Paty, J

doi:10.1016/s0165-1781(98)00091-2

Cited by 23 publications

(20 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The OCD and the GTS+OCD group showed reduced rare-target P300 amplitude, mainly in the right anterior region, but otherwise did not differ significantly from each other. The target P300 amplitude was also negatively correlated with OCD, which confirmed numerous findings reported in OCD (Beech, Ciesielski, & Gordon, 1983;Malloy, Rasmussen, Braden, & Haier, 1989;Miyata et al, 1998;Morault, Guillem, Bourgeois, & Paty, 1998;Morault, Bourgeois, Laville, Bensch, & Paty, 1997;Oades, Dittmann-Balcar, Schepker, Eggers, & Zerbin, 1996;Sanz, Molina, Martin-Loeches, Calcedo, & Rubia, 2001;Towey et al, 1994). Conversely, participants suffering from GTS showed larger target P300 amplitude, positively correlated with tic frequency.…”

Section: Inhibitory and Sensorimotor Integration Specificity In Gtssupporting

confidence: 87%

Neurocognitive Aspects of Tourette Syndrome and Related Disorders

Lavoie¹,

O’Connor²

2012

When Things Go Wrong - Diseases and Disorders of the Human Brain

View full text Add to dashboard Cite

Section: Inhibitory and Sensorimotor Integration Specificity In Gtssupporting

confidence: 87%

Neurocognitive Aspects of Tourette Syndrome and Related Disorders

Lavoie¹,

O’Connor²

2012

When Things Go Wrong - Diseases and Disorders of the Human Brain

View full text Add to dashboard Cite

“…However, our sample size compares to earlier samples in the ERP field, which used GTS patients samples at n=6 (Van de Wetering et al, 1985), n=10 (Johannes et al, 2001a(Johannes et al, ,b, 2003, n=12 (Johannes et al, 1997) and n=24 (van Woerkom et al, 1994). The same applies with ERP studies of OCD patients with various sample sizes from a n=8 (Di Russo et al, 2000), n=9 (Gehring et al, 2000), n=13 (Morault et al, 1997), n=15 (Sanz et al, 2001) and n=21 (Morault et al, 1998). Future research would ideally recruit larger samples and compare GTS+OCS with other comorbid groups such as highly anxious, depressive or hyperactive GTS patients.…”

Section: Possible Influences Of Confounding Variablesmentioning

confidence: 91%

“…Nevertheless, these P300 patterns were elicited in slightly different experimental procedures, so nuancing homogeneous interpretation of their functional significance across groups. In GTS, working memory processes have been found to be affected in complex attentional performance while in OCD, anomalies appeared non specifically across a wide spectrum of cognitive demands (Kim et al, 2003;Mavrogiorgou et al, 2002;Miyata et al, 1998;Morault et al, 1998;Sanz et al, 2001;Towey et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome

Thibault

Felezeu

O’Connor

et al. 2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

View full text Add to dashboard Cite

Approximately 30 to 50% of people suffering from Gilles de la Tourette Syndrome (GTS) also fulfill diagnostic criteria for obsessive-compulsive disorder (OCD). Despite this high degree of comorbidity, very few studies have addressed the question of obsessive-compulsive symptoms (OCS) in GTS patients using specific brain event-related potentials (ERP) responses. The aim of the current study was to quantify neurocognitive aspects of comorbidity, using ERPs. Fourteen adults with GTS (without OCD) were compared to a group of 12 participants with GTS and comorbid obsessive-compulsive symptoms (GTS+OCS), to a group of 15 participants with OCD and to a group of 14 control participants without neurological or psychiatric problems. The P200 and P300 components were recorded during a visual counting oddball task. Results showed intact P200 amplitude in all groups, whilst the P300 amplitude was affected differentially across groups. The P300 oddball effect was reduced in participants in both OCD and GTS+OCS groups in the anterior region. However, the P300 oddball effect was significantly larger in participants of the GTS group compared to all other groups, mostly in the parietal region. These findings suggest that adults with GTS are characterized by enhanced working memory updating processes and that the superimposition of OCS can lead to a reduction of these processes. The discrepancy between our findings and results obtained in previous studies on GTS could reflect the modulating effect of OCS on late ERP components.

show abstract

“…There were studies reporting diminished amplitudes of the P300 [33,34] and studies showing contradicting results with regard to its latency. For example, Sanz et al [34] found prolonged latency of auditory P300 before and after treatment, as compared with controls, while other researchers reported that OCD patients show shorter latencies [35][36][37].…”

Section: Introductionmentioning

confidence: 98%

Do Obsessive-Compulsive Patients and Abstinent Heroin Addicts Share a Common Psychophysiological Mechanism?

et al. 2003

View full text Add to dashboard Cite

Background/Aim: Working memory (WM) and attentional deficits have been implicated in the pathophysiology of both obsessive-compulsive disorder (OCD) and opioid addiction. The P300 component of event-related potentials (ERPs) is considered as an index of on-line updating of WM and/or attentional operations involved in this function. The present study aimed at comparing the P300 elicited during a WM test in patients with prolonged heroin abstinence, those with OCD and healthy controls, in order to demonstrate possibly common underlying psychophysiological mechanisms. Methods: The P300 component was evaluated during the anticipatory period of a WM test in 20 patients characterized by a past history of opioid dependence (6 months abstinence), in 18 OCD patients, and 20 healthy subjects matched for age, sex and educational level. Results: The two patient groups showed a considerable reduction of the P300 amplitudes, located at the right frontal area as compared with healthy controls. The abstinent heroin addicts exhibited a significantly lower P300 amplitude at central frontal areas and a significantly higher P300 amplitude at the left occipital region relative to the other two groups. Furthermore, the abstinent group showed a notable delay of P300 latency relative to controls and OCD patients at the right occipital region. Moreover, the OCD patients manifested a significant prolongation of P300 located at the central prefrontal area, relative to addicts and healthy controls. Conclusions: These findings point to considerable WM and/or attentional deficits in the long-term abstinent syndrome of heroin misuse and OCD associated with distributed and prefrontal cortical circuits, respectively. Furthermore, the present findings suggest that both OCD and long-term abstinent heroin addicts may share a common impairment of WM and/or attention involving or affecting the right prefrontal areas.

show abstract

Improvement predictors in obsessive-compulsive disorder. An event-related potential study

Cited by 23 publications

References 22 publications

Neurocognitive Aspects of Tourette Syndrome and Related Disorders

Neurocognitive Aspects of Tourette Syndrome and Related Disorders

Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome

Do Obsessive-Compulsive Patients and Abstinent Heroin Addicts Share a Common Psychophysiological Mechanism?

Contact Info

Product

Resources

About