Improvements in diagnosis have changed the incidence of histological types in advanced gastric cancer

Ikeda, Yoichi; Mori, Masaki; Kamakura, Tatsuro; Haraguchi, Yukiaki; Saku, Motonori; Sugimachi, Keizō

doi:10.1038/bjc.1995.349

Cited by 23 publications

(16 citation statements)

References 16 publications

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“…However, the decline in the diffuse type has been more gradual. In some series, although intestinal type gastric cancer remained the predominant subtype, the relative proportion of diffuse type cancer became higher over the course of time, (23)(24)(25)(26)(27) but this is not noted in all studies. (28,29) The reasons for this relative increase in the proportion of diffuse type cancer are speculative.…”

Section: Clinical Epidemiology Of Gastric Cancermentioning

confidence: 99%

Clinical epidemiology of gastric cancer

Ang

Fock

2014

smedj

316

223

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Gastric cancer is the second leading cause of cancer-related mortality and the fourth most common cancer globally. There are, however, distinct differences in incidence rates in different geographic regions. While the incidence rate of gastric cancer has been falling, that of gastric cardia cancers is reportedly on the rise in some regions. Helicobacter pylori (H. pylori) infection is a major risk factor of non-cardia gastric cancer, and data has emerged concerning the role of H. pylori eradication for primary prevention of gastric cancer. Dietary, lifestyle and metabolic factors have also been implicated. Although addressing these other factors may contribute to health, the actual impact in terms of cancer prevention is unclear. Once irreversible histological changes have occurred, endoscopic surveillance would be necessary. A molecular classification system offers hope for molecularly tailored, personalised therapies for gastric cancer, which may improve the prognosis for patients.

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Section: Clinical Epidemiology Of Gastric Cancermentioning

confidence: 99%

Clinical epidemiology of gastric cancer

Ang

Fock

2014

smedj

316

223

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“…On the other hand, the decline in the diffuse type has been more gradual. Consequently, the diffuse type represents about 30 percent of gastric carcinoma [8].…”

Section: Distribution Of Histologic Typesmentioning

confidence: 99%

Gastric Cancer: An Epidemiological Overview

Benbrahim¹,

Mekkaoui²,

Lahmidani³

et al. 2017

Epidemiology

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Gastric cancer constitutes one of the leading causes of cancer incidence and mortality in the worldwide despite its decline over the past century. In this article we will first review descriptive epidemiology of gastric cancer. Next we will discuss its precursors and risk factors; the principal risk factors of stomach cancer are HP Infection, smoking, high salt intake and genetic factors. Finally we will discuss screening strategies and prevention of gastric cancer.

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“…Some studies have reported an increase in the diffuse type of gastric carcinoma, especially the signet-ring cell type [6] . As a result, the diffuse type now accounts for about 30% of gastric carcinomas in some reported series [7] . Intestinal-type and diffuse-type gastric cancer differ in their epidemiology, pathogenesis, genetic profile, and clinical outcome [8] .…”

Section: Introductionmentioning

confidence: 99%

LINE-1 family member GCRG123 gene is up-regulated in human gastric signet-ring cell carcinoma

Wang

Wang²,

Wu³

et al. 2008

WJG

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AIM:To analyze the expression profiles of a human gastriccancer-related gene, GCRG123 , in human gastric signetring cell carcinoma tissues, and to perform bioinformatics analysis on GCRG123 . METHODS:In situ hybridization was used to explore the GCRG123 expression pattern in paraffin-embedded gastric tissues, including 15 cases of signet-ring cell carcinoma, 15 of intestinal-type adenocarcinoma, and 15 of normal gastric mucosa. Northern blotting was used to analyze the differences in GCRG123 expression between stomach signet-ring cell carcinoma and intestinal-type adenocarcinoma tissues. Online software, including BLAST, Multalin and BLAT, were applied for bioinformatics analysis. National Center for Biotechnology Information (NCBI) and the University of California Santa Cruz (UCSC) databases were used for the analyses. RESULTS:The in situ hybridization signal appeared as blue precipitates restricted to the cytoplasm. Ten out of 15 cases of gastric signet ring cell carcinoma, normal gastric mucosal epithelium and pyloric glands showed high GCRG123 expression. Low GCRG123 expression was observed in gastric intestinal-type adenocarcinoma and normal gastric glands. Northern blotting revealed that GCRG123 was up-regulated in signet-ring cell carcinoma tissue but down-regulated in intestinal-type adenocarcinoma tissue. BLAST and Multalin analyses revealed that the GCRG123 sequence had 92% similarity with the ORF2 sequence of human long interspersed nuclear element retrotransposons (LINE-1, L1).BLAT analysis indicated that GCRG123 mapped to all chromosomes. GCRG123 was found to integrate in the intron-17 and -23 of Rb, 5' flanking region of IL-2 and clotting factor Ⅸ genes. LINE-1 family member GCRG123 gene is up-regulated in human gastric signet-ring cell carcinoma. World

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Improvements in diagnosis have changed the incidence of histological types in advanced gastric cancer

Cited by 23 publications

References 16 publications

Clinical epidemiology of gastric cancer

Clinical epidemiology of gastric cancer

Gastric Cancer: An Epidemiological Overview

LINE-1 family member GCRG123 gene is up-regulated in human gastric signet-ring cell carcinoma

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