Improvements in LED-based fluorescence analysis systems

Moe, A.E.; Marx, S.R.; Banani, N.; Liu, Matthew Tingchi; Marquardt, Brian J.; Wilson, Denise

doi:10.1016/j.snb.2005.01.057

Cited by 37 publications

(34 citation statements)

References 8 publications

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“…They are also less attractive sources for battery operation due to the high current power (25 A) required and are ignition sources which are often considered an explosion hazard without suitable precautions. 47 In contrast, LEDs and LDs as LIF excitation sources offer many attractive attributes. First, these sources afford superior emission signal precision and accuracy due to their high spectral quality, narrow spectral characteristics (quasi -monochromatic) and reliable output.…”

Section: Lif P Hotometric I Nstrument S Pecifi Cationmentioning

confidence: 99%

“…When an excitation fi lter is required (i.e., small Stokes shift), the resulting attenuation may be offset by increasing the source optical power to provide the desired signal characteristics. Moreover, these sources afford real -time ' dynamic ' optical power control 10,47 to exploit the optical power fl uorescent advantage. This is advantageous as it provides a powerful approach in optimizing the response functions (i.e., SBR and SNR) and analytical merits (sensitivity, detection limits, etc.)…”

Section: Lif P Hotometric I Nstrument S Pecifi Cationmentioning

confidence: 99%

“…This can be accommodated by various means such as the diode drive current or selective diode activation within the array. 10,47 LEDs are also compact thereby affording arrays or spectral domain versatility without the need for additional high overhead optics (e.g., grating). 25 Finally, the signifi cantly reduced power requirement of these sources is much more suitable for battery powered devices.…”

Section: Lif P Hotometric I Nstrument S Pecifi Cationmentioning

confidence: 99%

“…In recent years these narrow band light sources have become more common within various instrumental devices as various commercial vendors now provide LEDs throughout the UV -vis range. 45,47 Lasers have been omitted as a potential light source for process LIF instruments as they are inappropriate in many real -time applications due to several signifi cant limitations. Consequently, before the advent of LEDs suitable for fl uorescence analysis, lasers were the only excitation source affording exploitation of the optical power emission advantage.…”

Section: Lif P Hotometric I Nstrument S Pecifi Cationmentioning

confidence: 99%

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Fluorescent Sensing and Process Analytical Applications

Dickens¹

2010

Process Analytical Technology

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Section: Lif P Hotometric I Nstrument S Pecifi Cationmentioning

confidence: 99%

Section: Lif P Hotometric I Nstrument S Pecifi Cationmentioning

confidence: 99%

Section: Lif P Hotometric I Nstrument S Pecifi Cationmentioning

confidence: 99%

Section: Lif P Hotometric I Nstrument S Pecifi Cationmentioning

confidence: 99%

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Fluorescent Sensing and Process Analytical Applications

Dickens¹

2010

Process Analytical Technology

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“…The use of LEDs as excitation sources is becoming increasingly common [36]. LEDs demonstrate several advantages over lasers such as lower cost, higher efficiency and better intensity stability.…”

Section: Ledsmentioning

confidence: 99%

Noise analysis and measurement of integrator-based sensor interface circuits for fluorescence detection in lab-on-a-chip applications

Jensen

Gaudet

Levine

2013

2013 22nd International Conference on Noise and Fluctuations (ICNF)

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Lab-on-a-chip (LOC) biological assays have the potential to fundamentally reform healthcare. The move away from centralized facilities to Point-of-Care (POC) testing of biological assays would improve the speed and accuracy of these, thereby improving patient care. Before LOC can be realized, a number of challenges must be addressed: the need for expert users must be abstracted away; the manufacturing cost of $5 per test threshold must be met; and the supporting infrastructure must be integrated down to an easily portable size. These challenges can be addressed with the deposition of microfluidics on CMOS chips. By designing application specific integrated circuits (ASICs) much of the automation and the supporting infrastructure needed to run these assays can be integrated into the chip. Additionally, CMOS fabrication is some of the most optimized manufacturing in industry today. My parents, thank you for providing me with food and shelter while in Alberta and never ending support while I was in Ontario. Keesa, my lovely fiance, without you I never would have gotten this far; probably not even close. Evelyn, your kitchen table debates over genetics and technology pushed me to discover new knowledge; endless appreciation.To my colleges at the U of A:

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Ultraviolet Photodissociation Induced by Light‐Emitting Diodes in a Planar Ion Trap

et al. 2016

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The first application of light-emitting diodes (LEDs) for ultraviolet photodissociation (UVPD) mass spectrometry is reported. LEDs provide ac ompact, low cost light source and have been incorporated directly into the trapping cell of an Orbitrap mass spectrometer.M S/MS efficiencies of over 50 % were obtained using an extended irradiation period, and UVPD was optimizedb ym odulating the ion trapping parameters to maximizet he overlap between the ion cloud and the irradiation volume.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: http://dx.

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Improvements in LED-based fluorescence analysis systems

Cited by 37 publications

References 8 publications

Fluorescent Sensing and Process Analytical Applications

Fluorescent Sensing and Process Analytical Applications

Noise analysis and measurement of integrator-based sensor interface circuits for fluorescence detection in lab-on-a-chip applications

Ultraviolet Photodissociation Induced by Light‐Emitting Diodes in a Planar Ion Trap

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