Improvements in PET Image Quality in Time of Flight (TOF) Simultaneous PET/MRI

Minamimoto, Ryogo; Levin, Craig S.; Jamali, Mehran; Holley, Dawn; Barkhodari, Amir; Zaharchuk, Greg; Iagaru, Andrei

doi:10.1007/s11307-016-0939-8

Cited by 27 publications

(15 citation statements)

References 25 publications

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“…19,20 Benefits of ToF for clinical PET/MR imaging have been demonstrated in a separate work. 21 The energy resolution has been previously measured at 10.3% with MR idle and 10.5% with continuous pulsing of the 2-point Dixon method sequence used for MR-based AC. 14,16 The PET electronics incorporate a dynamic temperature compensation system that maintains gain stability under MR pulsing, preventing large photopeak gain shifts.…”

Section: Introductionmentioning

confidence: 99%

NEMA NU 2-2012 performance studies for the SiPM-based ToF-PET component of the GE SIGNA PET/MR system

Deller²,

et al. 2016

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Section: Introductionmentioning

confidence: 99%

NEMA NU 2-2012 performance studies for the SiPM-based ToF-PET component of the GE SIGNA PET/MR system

Deller²,

et al. 2016

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“…Hybr id PET/MRI is a recent advance in multimodality imaging, providing both anatomic and functional information (1,2), and has several important advantages over PET/CT systems. First, MRI is considered superior to CT for showing soft-tissue contrast and is regarded as the first-line imaging procedure in oncology for soft-tissue regions (e.g., tumors in the brain, the head-and-neck region, the musculoskeletal region, and the pelvis) (3).…”

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confidence: 99%

Comparison of PET/CT with Sequential PET/MRI Using an MR-Compatible Mobile PET System

Nakamoto

Ishimori

et al. 2017

J Nucl Med

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The current study tested a newly developed flexible PET (fxPET) scanner prototype. This fxPET system involves dual arc-shaped detectors based on silicon photomultipliers that are designed to fit existing MRI devices, allowing us to obtain fused PET and MR images by sequential PET and MR scanning. This prospective study sought to evaluate the image quality, lesion detection rate, and quantitative values of fxPET in comparison with conventional whole-body (WB) PET and to assess the accuracy of registration. Seventeen patients with suspected or known malignant tumors were analyzed. Approximately 1 h after intravenous injection ofF-FDG, WB PET/CT was performed, followed by fxPET and MRI. For reconstruction of fxPET images, MRI-based attenuation correction was applied. The quality of fxPET images was visually assessed, and the number of detected lesions was compared between the 2 imaging methods. SUV and maximum average SUV within a 1 cm spheric volume (SUV) of lesions were also compared. In addition, the magnitude of misregistration between fxPET and MR images was evaluated. The image quality of fxPET was acceptable for diagnosis of malignant tumors. There was no significant difference in detectability of malignant lesions between fxPET and WB PET ( > 0.05). However, the fxPET system did not exhibit superior performance to the WB PET system. There were strong positive correlations between the 2 imaging modalities in SUV (ρ = 0.88) and SUV (ρ = 0.81). SUV and SUV measured with fxPET were approximately 1.1-fold greater than measured with WB PET. The average misregistration between fxPET and MR images was 5.5 ± 3.4 mm. Our preliminary data indicate that running an fxPET scanner near an existing MRI system provides visually and quantitatively acceptable fused PET/MR images for diagnosis of malignant lesions.

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“…Two board-certified nuclear medicine physicians assessed the quality of the PET images on a 3-point scale. Although a trend for improved image quality using the TOF information was observed, the only difference between the visual assessment scores that reached statistical significance was reported in the case of the pelvic artifacts (76). …”

Section: Mr-based Pet Attenuation Correctionmentioning

confidence: 91%

Principles of Simultaneous PET/MR Imaging

Catana

2017

Magnetic Resonance Imaging Clinics of North America

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Improvements in PET Image Quality in Time of Flight (TOF) Simultaneous PET/MRI

Abstract: The superior timing resolution and resulting TOF capability of the new PET/MRI scanner improved PET image quality in this cohort by reducing artifacts compared to non-TOF PET/MRI, TOF PET/CT, and non-TOF PET/CT.

Cited by 27 publications

References 25 publications

NEMA NU 2-2012 performance studies for the SiPM-based ToF-PET component of the GE SIGNA PET/MR system

NEMA NU 2-2012 performance studies for the SiPM-based ToF-PET component of the GE SIGNA PET/MR system

Comparison of PET/CT with Sequential PET/MRI Using an MR-Compatible Mobile PET System

Principles of Simultaneous PET/MR Imaging

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