Improvements in Topical Ocular Drug Delivery Systems:  Hydrogels and Contact Lenses

Ribeiro, Andreza Maria; Figueiras, Ana; Veiga, Francisco

doi:10.18433/j3h60p

Cited by 32 publications

(17 citation statements)

References 81 publications

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“…The magnetic stirring speed was 100 rpm. At predetermined time points (2,4,6,8,10,12,24, and 36 h), 1 mL of each sample was withdrawn and immediately replaced with an equal volume of fresh Ringer's solution. The amount of drug released by L/NPs was determined by the HPLC method as described in the "Analysis of drug-loading efficiency and capacity" section.…”

Section: In Vitro Drug Release Testmentioning

confidence: 99%

“…Three methods are used for drug delivery to the posterior segment and fundus in clinical settings ( Figure 1). [1][2][3][4][5][6][7] The first method has been applied to the treatment of posterior segment disease and involves injection or implantation of the drug into the vitreous humor via the flat part of the ciliary body. The second method targets the subconjunctival fascia by implantation or injection, with the drug eventually becoming concentrated in the choroid, retinal pigment epithelium, retina, etc.…”

Section: Introductionmentioning

confidence: 99%

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Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone

Ban¹,

Zhang²,

Huang³

et al. 2017

IJN

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Drug delivery carriers can maintain effective therapeutic concentrations in the eye. To this end, we developed lipid nanoparticles (L/NPs) in which the surface was modified with positively charged chitosan, which engaged in hydrogen bonding with the phospholipid membrane. We evaluated in vitro corneal permeability and release characteristics, ocular irritation, and drug dynamics of modified and unmodified L/NPs in aqueous humor. The size of L/NPs was uniform and showed a narrow distribution. Corneal permeation was altered by the presence of chitosan and was dependent on particle size; the apparent permeability coefficient of dexamethasone increased by 2.7 and 1.8 times for chitosan-modified and unmodified L/NPs, respectively. In conclusion, a chitosan-modified system could be a promising method for increasing the ocular bioavailability of unmodified L/NPs by enhancing their retention time and permeation into the cornea. These findings provide a theoretical basis for the development of effective drug delivery systems in the treatment of ocular disease.

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Section: In Vitro Drug Release Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone

Ban¹,

Zhang²,

Huang³

et al. 2017

IJN

View full text Add to dashboard Cite

show abstract

“…The cornea is structured into the epithelium, stroma, rich in water and endothelium. Most of the drugs delivered to the eye are drops, ointments, hydrogels and extended release devices, such as contact lens for local action [232]. Absorption through the conjunctiva offers an entry into the bloodstream.…”

Section: Implications Of Ocular Mucins On Drug Deliverymentioning

confidence: 99%

“…The cornea and conjunctiva are covered with the tear fluid, which besides secreted mucins contains electrolytes, albumin and lysozyme and on its top lays a lipid barrier (secretion by the Meibomian glands). In normal conditions, only a very small volume of administered drugs, circa 30 µl, can be applied without overflowing [232,233]. The composition of eye drops can enhance tear flow reducing drug concentration at the epithelium.…”

Section: Implications Of Ocular Mucins On Drug Deliverymentioning

confidence: 99%

A slippery slope: On the origin, role and physiology of mucus

Taherali

Varum

Basit

2018

Advanced Drug Delivery Reviews

146

127

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The mucosa of the gastrointestinal tract, eyes, nose, lungs, cervix and vagina is lined by epithelium interspersed with mucus-secreting goblet cells, all of which contribute to their unique functions. This mucus provides an integral defence to the epithelium against noxious agents and pathogens. However, it can equally act as a barrier to drugs and delivery systems targeting epithelial passive and active transport mechanisms. This review highlights the various mucins expressed at different mucosal surfaces on the human body, and their role in creating a mucoid architecture to protect epithelia with specialized functions. Various factors compromising the barrier properties of mucus have been discussed, with an emphasis on how disease states and microbiota can alter the physical properties of mucus. For instance, Akkermansia muciniphila, a bacterium found in higher levels in the gut of lean individuals induces the production of a thickened gut mucus layer. The aims of this article are to elucidate the different physiological, biochemical and physical properties of bodily mucus, a keen appreciation of which will help circumvent the slippery slope of challenges faced in achieving effective mucosal drug and gene delivery.

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“…The molecule has a water-soluble hydrophilic exterior, and an apolar cavity that provides a hydrophobic matrix capable of hosting a wide range of guest molecules, ranging from polar molecules to a polar molecule [103]. CD (cyclic oligosaccharides, CDs) have been proposed as a new attractive biomaterial to obtain hydrogels, combining both, the favorable property of CDs to form inclusion complexes and the swelling behavior of hydrogels [104].…”

Section: Cyclodextrins (Cd)mentioning

confidence: 99%

Diabetic Retinopathy: An Inclusive Review on Current Treatment and Management Approaches

Jyothi

2018

Asian J Pharm Clin Res

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Diabetic retinopathy (DR) is a complication which occurs due to diabetes mellitus leading to loss of vision and hindering the quality of patient life by damaging the layer of retina at the posterior segment of the eye. According to the survey around 285 million peoples are suffering from visual loss out of these 65% of people are more than 50 years old and 82% of blind patients are more than 50 years old. The diseases that occur in the posterior segment of the eye like, cytomegalovirus retinitis, posterior uveitis, age related macular degeneration and diabetic retinopathy needs a novel delivery system that can improve the concentration of drugs that reaches posterior segment of the eye. The development of new drug delivery system gained more importance in the field of research in which nanotechnology is the most considered approach. The nanotechnology-based systems such as nanoparticles, nanoliposomes, niosomes, nanomicelles, nanoemulsions, nanogels, cyclodextrins, dendrimers, and quantum dots are developed as a new formulation for drug delivery. The rationale behind the nanoparticle systems is its ability to formulate a sustained, controlled release dosage form, painless, safe, non-invasive system to overcome the major barriers in the treatment of DR. Based on the nanoparticles, some approaches are exploited for more effective conveyance of drug toward the posterior segment. Thus, these advanced delivery systems progress the therapeutic efficacy of the drug and patient’s obedience and life quality. In this review, the new therapeutic treatments and their managements were discussed and methods of drug delivery to reach the posterior segment of eye.

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Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

Cited by 32 publications

References 81 publications

Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone

Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone

A slippery slope: On the origin, role and physiology of mucus

Diabetic Retinopathy: An Inclusive Review on Current Treatment and Management Approaches

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