Improving and measuring the solubility of favipiravir and montelukast in SC-CO₂ with ethanol projecting their nanonization

Abstract

Improving and measuring the solubility of favipiravir and montelukast in SC-CO2 with ethanol projecting their nanonization.

Solubility Measurement and Correlation of Alprazolam in Carbon Dioxide with/without Ethanol at Temperatures from 308 to 338 K and Pressures from 120 to 300 bar

“…Additionally, CO 2 can be easily removed from the extract by just reducing pressure. − A lot of compounds, such as lower alcohols, water, and some hydrocarbons, are thought to be promising supercritical fluids, and all of them take advantages of their combination of features corresponding to liquids (high dissolving capacity) and high-pressure gases (high diffusion coefficient and low density). − Nonetheless, scCO 2 has certain limitations such as its lack of polarity, which avoids establishing specific interactions with other solvents and solutes. Consequently, there is a strong motivation to enhance its polarity using strategies such as adding small quantities of an appropriate cosolvent. − The idea of including a cosolvent in an SCF has been an area of interest for many years. − Supercritical carbon dioxide has shown a great ability in various fields including extraction of essential oil , and seed oil, , solubility, nanoparticle formation, − impregnation, , optimization and mathematical modeling, , and polymer synthesis . Supercritical-fluid-based advancements cover a wide range of applications such as extraction, impregnation, formulation, particle formation, sterilization, cleaning, chemical reactions, energy production, and waste treatment.…”