Improving Angiogenesis and Muscle Performance in the Ischemic Limb Model by Physiological Ischemic Training in Rabbits

Zhao, Yan; Li, Jianan; Lin, Aicui; Xiao, Mingyue; Xiao, Bo; Wan, Chunxiao

doi:10.1097/phm.0b013e318238a166

Cited by 12 publications

(19 citation statements)

References 29 publications

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“…In this study, we had used blood cuffs placed around the hind limbs with inflation to 200 mmHg until the femoral artery pulse disappeared rather than isometric exercise. 9 This style of PIT may have a potential use in patients with ischaemic cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

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Physiologic ischaemic training induces endothelial progenitor cell mobilization and myocardial angiogenesis via endothelial nitric oxide synthase related pathway in rabbits

Xiao

Lü

et al. 2014

Journal of Cardiovascular Medicine

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Section: Discussionmentioning

confidence: 99%

“…8 PIT could be a well-tolerated, non-invasive modality to enhance angiogenesis. 9,10 However, the mechanisms for its therapeutic effects are not completely understood.…”

Section: Introductionmentioning

confidence: 99%

Physiologic ischaemic training induces endothelial progenitor cell mobilization and myocardial angiogenesis via endothelial nitric oxide synthase related pathway in rabbits

Xiao

Lü

et al. 2014

Journal of Cardiovascular Medicine

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“…PIT is a technique whereby skeletal muscle is subjected to intense contraction via isometric contraction or tourniquet in order to stimulate physiological ischemia (Ni et al, 2015). In animal models, PIT applied eight times daily for 4 weeks to a normal healthy limb has been shown to upregulate vascular endothelial growth factor (VEGF) and facilitate angiogenesis improving blood flow and capillary supply in a remote pathological ischemeic limb (Shen et al, 2009; Zhao et al, 2011). In clinical trials, PIT using isometric handgrip exercise performed at 50% maximal voluntary contraction (MVC) by patients with coronary artery disease and a coronary artery occlusion significantly increased collateral blood flow in the myocardium (Lin et al, 2012).…”

Section: Remote Limb Ischemia To Affect Distant Organsmentioning

confidence: 99%

Isometric Exercise Training for Managing Vascular Risk Factors in Mild Cognitive Impairment and Alzheimer’s Disease

Hess

Smart

2017

Front. Aging Neurosci.

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Alzheimer’s disease (AD) is the most common form of dementia diagnosed amongst the elderly. Mild cognitive impairment (MCI) is a condition often indicative of the earliest symptomatology of AD with 10%–15% of MCI patients reportedly progressing to a diagnosis of AD. Individuals with a history of vascular risk factors (VRF’s) are considered high risk candidates for developing cognitive impairment in later life. Evidence suggests that vascular injury resulting from untreated VRF’s promotes progression from MCI to AD and exacerbates the severity of dementia in AD, and neuroimaging studies have found that the neurodegenerative processes associated with AD are heavily driven by VRF’s that promote cerebral hypoperfusion. Subsequently, common links between vascular disorders such as hypertension and neurodegenerative disorders such as AD include compromised vasculature, cerebral hypoperfusion and chronic low grade inflammation (a hallmark of both hypertension and AD). Exercise has been demonstrated to be an effective intervention for blood pressure management, chronic low grade inflammation and improvements in cognition. Data from recent analyses suggests that isometric exercise training (IET) may improve vascular integrity and elicit blood pressure reductions in hypertensives greater than those seen with dynamic aerobic and resistance exercise. IET may also play an effective role in the management of VRF’s at the MCI stage of AD and may prove to be a significant strategy in the prevention, attenuation or delay of progression to AD. A plausible hypothesis is that the reactive hyperemia stimulated by IET initiates a cascade of vascular, neurotrophic and neuro-endocrine events that lead to improvements in cognitive function.

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“…Based on these suggestions, an intermittent low‐intensity “aerobic” BFR training protocol, but with BFR applied only during the exercise (deflating the cuffs during rest periods), could provide a greater training stimulus, i.e., a higher tolerable training intensity and/or duration and occlusion pressures leading to high order fibers recruitment. Additionally, the brief episodes of low and high O 2 exposure in skeletal muscle, generated by the cycles of cuffs inflation and deflating (i.e., ischemia‐reperfusion), could also induce additional training‐effects on oxidative metabolism and angiogenesis (Clanton & Klawitter, ; Zhao et al., ). Therefore, the application of an intermittent compared with continuous BFR may be advantageous in trying to induce simultaneous gains in aerobic fitness and muscle strength.…”

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confidence: 99%

Short‐term low‐intensity blood flow restricted interval training improves both aerobic fitness and muscle strength

Oliveira

Caputo

Corvino

et al. 2015

Scandinavian Med Sci Sports

111

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The present study aimed to analyze and compare the effects of four different interval-training protocols on aerobic fitness and muscle strength. Thirty-seven subjects (23.8 ± 4 years; 171.7 ± 9.5 cm; 70 ± 11 kg) were assigned to one of four groups: low-intensity interval training with (BFR, n = 10) or without (LOW, n = 7) blood flow restriction, high-intensity interval training (HIT, n = 10), and combined HIT and BFR (BFR + HIT, n = 10, every session performed 50% as BFR and 50% as HIT). Before and after 4 weeks training (3 days a week), the maximal oxygen uptake (VO2max ), maximal power output (Pmax ), onset blood lactate accumulation (OBLA), and muscle strength were measured for all subjects. All training groups were able to improve OBLA (BFR, 16%; HIT, 25%; HIT + BFR, 22%; LOW, 6%), with no difference between groups. However, VO2max and Pmax improved only for BFR (6%, 12%), HIT (9%, 15%) and HIT + BFR (6%, 11%), with no difference between groups. Muscle strength gains were only observed after BFR training (11%). This study demonstrates the advantage of short-term low-intensity interval BFR training as the single mode of training able to simultaneously improve aerobic fitness and muscular strength.

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Improving Angiogenesis and Muscle Performance in the Ischemic Limb Model by Physiological Ischemic Training in Rabbits

Abstract: Physiologic ischemic exercise training can promote remote angiogenesis in the pathologic ischemic skeletal muscle and thus improve performance.

Cited by 12 publications

References 29 publications

Physiologic ischaemic training induces endothelial progenitor cell mobilization and myocardial angiogenesis via endothelial nitric oxide synthase related pathway in rabbits

Physiologic ischaemic training induces endothelial progenitor cell mobilization and myocardial angiogenesis via endothelial nitric oxide synthase related pathway in rabbits

Isometric Exercise Training for Managing Vascular Risk Factors in Mild Cognitive Impairment and Alzheimer’s Disease

Short‐term low‐intensity blood flow restricted interval training improves both aerobic fitness and muscle strength

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