Improving aqueous solubility of ciprofloxacin: three different stoichiometric hydrated salt forms with oxalic acid

Abstract

Ciprofloxacin (CIF) is a powerful synthetic antibiotic usually used for chest, skin, and bone infections when the patients have resisted other antibiotics. However, ciprofloxacin has a weakness in terms of...

Ciprofloxacin salts of benzene mono/di-carboxylate: crystal structures and the improvement of solubility

“…To improve the aqueous solubility, many efforts have been made to synthesize crystalline salts or cocrystals of ciprofloxacin with carboxylic acids: linear dicarboxylic acids such as oxalic acid, 23,33,35,36 aromatic carboxylic acids such as benzoic acid derivatives. 24,25,28,37,38 Among these examples, five distinct solid forms composed of ciprofloxacin and salicylic acid were prepared through mechanochemical synthesis.…”