Purpose of Review Recent Atlantic climate prediction studies are an exciting new contribution to an extensive body of research on Atlantic decadal variability and predictability that has long emphasized the unique role of the Atlantic Ocean in modulating the surface climate. We present a survey of the foundations and frontiers in our understanding of Atlantic variability mechanisms, the role of the Atlantic Meridional Overturning Circulation (AMOC), and our present capacity for putting that understanding into practice in actual climate prediction systems. Recent Findings The AMOC-or more precisely, the buoyancy-forced thermohaline circulation (THC) that encompasses both overturning and gyre circulations-appears to underpin decadal timescale prediction skill in the subpolar North Atlantic in retrospective forecasts. Skill in predicting more wide-ranging climate variations, including those over land, is more limited, but there are indications this could improve with more advanced models. Summary Preliminary successes in the field of initialized Atlantic climate prediction confirm the climate relevance of low-frequency Atlantic Ocean dynamics and suggest that useful decadal climate prediction is a realizable goal.