Improving Effect of Dietary Taurine Supplementation on the Oxidative Stress and Lipid Levels in the Plasma, Liver and Aorta of Rabbits Fed on a High-Cholesterol Diet

Methionine Supplementation Did Not Augment Oxidative Stress, Atherosclerotic Changes and Hepatotoxicity Induced by High Cholesterol Diet in C57BL/6J Mice

“…Similar toxic effects are also observed following excess cholesterol intake (17,19,39). Free radicals and lipid peroxides have been accepted to be responsible for the toxic effects observed due to excess dietary amounts of both methionine (3,4,7,13,14) and cholesterol (16 21).…”

“…These authors also reported a significant elevation in lipid peroxide levels and GSH-Px, catalase and SOD On the other hand, an HC diet also affects the proox idant and antioxidant balance in the tissues (16)(17)(18)(19)(20)(21). Indeed, severe hypercholesterolemia and vascular ath erosclerotic lesions as well as an increase in oxidative stress in plasma, erythrocytes and several tissues such as liver and aorta have been observed in rabbits follow ing the feeding of an HC diet (16)(17)(18)(19)(20). Contrarily, ath erosclerotic changes were not observed in the aorta of rats following the feeding of an HC diet (12,18,21), although lipid peroxidation increased and the antioxi dant system was affected in some tissues (16,18,21).…”

“…On the other hand, a high-cholesterol (HC) diet resulted in a significant increase in serum (16)(17)(18), erythrocyte (19), liver (17,18,20) and aorta (17,18,20) lipid peroxide levels, as well as significant alter ations in the antioxidant system and typical atheroscle rotic changes in the aorta of rabbits. However, in rats, an HC diet does not induce atherosclerotic changes in the aorta (12,21) and erythrocyte hemolysis (22), although this diet produces changes in prooxidant and antioxidant balance in some tissues (16,18,21).…”

Effect of Blueberry Feeding on Lipids and Oxidative Stress in the Serum, Liver and Aorta of Guinea Pigs Fed on a High-Cholesterol Diet

“…[2][3][4][5] The potential roles of several antioxidants in high cholesterol (HC)-induced atherosclerosis have therefore been investigated. 4,5) Blueberries (BB; Vaccinium corymbosum L.) contain polyphenols and flavonols. The use of BB has been suggested to be useful in oxidative stress-related conditions.…”

Effect of a Taurine Treatment on the Regression of Existing Atherosclerotic Lesions in Rabbits Fed on a High-cholesterol Diet

“…1,6) We have recently reported that taurine ameliorated cholesterol accumulation and cholesterol-induced oxidative stress in the plasma, liver, and aorta of rabbits fed on a high-cholesterol (HC) diet, and that this may have been related to its antioxidative effect, besides the reducing effect on serum lipids in this study. 10) We investigated in this study whether or not taurine has any regressive effect on existing atherosclerotic lesions and oxidative stress in rabbits fed on an HC diet.…”