Improving Enrollment in Cancer Clinical Trials

Connolly, Nancy B.; Schneider, Dona; Hill, Ann Marie

doi:10.1188/04.onf.610-614

Cited by 16 publications

(9 citation statements)

References 12 publications

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“…Oncology was the most frequently mentioned clinical specialty [32, 34, 35, 38, 41, 43, 45, 48] and clinical trials were the most common type of research discussed [32, 34, 35, 37, 38, 41, 43-46, 48]. The term ‘researcher’ was not clearly defined, with some studies combining the views of recruiting doctors and nurses, principal investigators and trial managers [34], others looking solely at the perspectives of research assistants or associates [33, 38, 48], and others exploring the experience of research nurses [35, 44, 47] or scientists [40]. Similarly, the studies focused on a range of clinicians, including pharmacists [36], doctors [31, 32, 37, 41, 43, 44], midwives [39], nurses [46] and the whole multi-disciplinary team [45].…”

Section: Resultsmentioning

confidence: 99%

“…Less attention was given to establishing a collaborative relationship with the local population or target patient groups. Researchers from studies involving minority groups highlighted the value of pre-research trust-building activities, such as free screening sessions, holding meetings in the local community and involving key community members in research design and recruitment [35, 37]. …”

Section: Resultsmentioning

confidence: 99%

“…Some individuals found this situation difficult to reconcile and remained suspicious of research, viewing it as an additional burden and a competitor for their patients’ attention [34, 36, 37, 43]. However, the majority welcomed the opportunity to be involved in the progression of clinical practice and also saw participation in research as providing patient benefit [34, 35, 43-48]. Researchers and clinicians viewed research involvement as an opportunity for personal career progression or to improve institutional status [40, 41, 44], however, some researchers commented on the lack of career structure and difficulty retaining experienced staff [42].…”

Section: Resultsmentioning

confidence: 99%

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Researchers’ and Clinicians’ Perceptions of Recruiting Participants to Clinical Research: A Thematic Meta-Synthesis

Newington

Metcalfe

2014

J Clin Med Res

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BackgroundRecruiting the desired number of research participants is frequently problematic with resulting financial and clinical implications. The views of individuals responsible for participant recruitment have not been previously reviewed. This systematic review and thematic meta-synthesis explores researchers’ and clinicians’ experiences and perceptions of recruiting participants to clinical research, with the aim of informing improved recruitment systems and strategies.MethodsStudies published between January 1995 and May 2013 were identified from: Ovid MEDLINE, Ovid EMBASE, Ovid PSYCHINFO, ASSIA, British Nursing Index, Scopus, Web of Science, CINAHL and PubMed. Included studies were original peer reviewed research, with qualitative methodologies and an aim of exploring the views of clinicians and/or researchers on recruitment to clinical research. Studies discussing the recruitment of patients unable to give informed consent were excluded. The findings sections of the relevant studies were free coded to identify key concepts which were grouped into hierarchical themes. The quality of the identified studies was assessed and the relative contribution of each paper was checked to ensure individual studies did not dominate in any theme.ResultsEighteen relevant papers were identified which examined the views of researchers and clinicians in 10 clinical specialties. Five main themes emerged: building a research community, securing resources, the nature of research, professional identities and recruitment strategies. The views of researchers and clinicians were similar, although the role of ‘researcher’ was inconsistently defined.ConclusionsThe general experience of recruiting participants to clinical research was one of competition and compromise. Competition arose over funding, staffing and participants, and between clinical and research responsibilities. Compromise was needed to create study designs that were acceptable to patients, clinicians and researchers. Forging relationships between clinical and research teams featured extensively, however the involvement of patients and the public within the research community was rarely discussed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Researchers’ and Clinicians’ Perceptions of Recruiting Participants to Clinical Research: A Thematic Meta-Synthesis

Newington

Metcalfe

2014

J Clin Med Res

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“…First, clinicians must establish trust between themselves and their patients [16]. This is especially important when working with minority patients who may mistrust researchers [27].…”

Section: Ensuring That Clinicians Communicate Effectively With Their mentioning

confidence: 99%

Recommendations for Enhancing Clinical Trials Education: a Review of the Literature

et al. 2010

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This study aims to apply the evidence-based practice (EBP) process to determine the factors that influence patients' understanding of, participation in, and satisfaction with clinical trials, the informed consent process, and treatment decisions and to make recommendations for improving clinical trials education. Beginning with evidence retrieval, the authors identified key search terms and searched MEDLINE--Ovid, MEDLINE--PubMed, and the Cumulative Index to Nursing and Allied Health Literature to identify articles published between July 2001 and July 2006 that highlighted clinical trials education. The articles were reviewed for clinical trials patient education information, clinician methods of communicating clinical trial information to patients, and patient satisfaction with the clinical trials process, including the informed consent process. As a result, practice changes were recommended for the patient/family, staff/community, and institution. From the literature review, 81 articles were identified. Recurring themes included decision-making, patient education, staff education, and pediatrics. Most articles focused on methods and strategies aimed at improving education at the patient/family, staff/community, and institutional levels. The issues surrounding clinical trial education are complex due to multiple variables interfering with poor patient understanding of, participation in, and satisfaction with clinical trial treatment decisions. On the basis of our findings, we recommend that clinicians involved in educating patients, families, staff, and communities about clinical trials have an awareness of and understanding for very complex issues.

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“…Solche Werbekampagnen kön-nen zwar niemals spezifische, individuelle Informationen ersetzen [9], dennoch kön-nen sie Menschen dazu ermutigen, den potenziellen Nutzen und den möglichen Nachteil einer Teilnahme an klinischen Projekten generell zu überdenken, sodass nicht nur die Teilnahme an klinischen Prü-fungen, sondern insgesamt auch deren gesellschaftliche Akzeptanz gefördert wird [9]. Die Verankerung dieses Wissens in der Bevölkerung wird als eine Schlüssel-maßnahme zur Verbesserung von Rekrutierungsmaßnahmen angesehen [10].…”

Section: Der Beginn Jeder Klinischen Studie: Die Rekrutierungunclassified

Die richtige Rekrutierung von Studienteilnehmern

Grün

Haefeli

2009

Bundesgesundheitsbl.

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Patient recruitment in clinical studies is an essential step early in a drug trial. The quality of this process determines the safety of the trial and may modulate the validity of the resulting scientific information. While there are good reasons to recruit participants as quickly as possible to accelerate drug development and promote new treatment options, it is even more important to safeguard health and well-being of the participant. Therefore all steps of recruitment from patient identification and patient availability to patient information and enrolment have to be tailored accordingly. This paper describes the numerous challenges in this task, pitfalls and risks that may jeopardize reliable and effective recruitment, and strategies to improve this important process.

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Improving Enrollment in Cancer Clinical Trials

Cited by 16 publications

References 12 publications

Researchers’ and Clinicians’ Perceptions of Recruiting Participants to Clinical Research: A Thematic Meta-Synthesis

Researchers’ and Clinicians’ Perceptions of Recruiting Participants to Clinical Research: A Thematic Meta-Synthesis

Recommendations for Enhancing Clinical Trials Education: a Review of the Literature

Die richtige Rekrutierung von Studienteilnehmern

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