2017
DOI: 10.1016/j.bbrc.2017.09.066
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Improving glycemic control in model mice with type 2 diabetes by increasing superoxide dismutase (SOD) activity using silk fibroin hydrolysate (SFH)

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Cited by 21 publications
(16 citation statements)
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“…In regard to the literature dealing with this topic, Harnedy et al [81] and Parthsarathy et al [98] reported a protein hydrolysate from blue whiting and boarfish with in vitro and in vivo antidiabetic properties, using cell cultures and mice. Similar research was carried out by Jung et al [232] with silk fibroin hydrolysate, and by Hsieh et al [162] with milk proteins. Mochida et al [233] reported that zein-derived peptides induced glycemic regulation via GLP-1 secretion, and DPP-IV inhibition in rats, whereas Ishikawa et al [234] obtained similar results by employing rice-derived peptides.…”
Section: Vertebrates Modelssupporting
confidence: 71%
“…In regard to the literature dealing with this topic, Harnedy et al [81] and Parthsarathy et al [98] reported a protein hydrolysate from blue whiting and boarfish with in vitro and in vivo antidiabetic properties, using cell cultures and mice. Similar research was carried out by Jung et al [232] with silk fibroin hydrolysate, and by Hsieh et al [162] with milk proteins. Mochida et al [233] reported that zein-derived peptides induced glycemic regulation via GLP-1 secretion, and DPP-IV inhibition in rats, whereas Ishikawa et al [234] obtained similar results by employing rice-derived peptides.…”
Section: Vertebrates Modelssupporting
confidence: 71%
“…Flavonoids contained in torbangun leaves extract were able to provide protection against oxidative stress, which can be partially associated with a mechanism involving SOD activity. Jung et al (2017) stated that this increase in SOD activity was able to prevent the death of pancreatic β-cells, thereby being able to recover hyperglycemia and insulin intolerance.…”
Section: Animal Testmentioning
confidence: 99%
“…It has been shown in previous study that the pancreatic β-cells in DM subjects had a very low SOD (Jung et al 2017). Thus, through this mechanism, the flavonoids in torbangun leaves extract can act as an antioxidant that help the DM recovery process (Suryowati et al 2015b).…”
Section: Introductionmentioning
confidence: 95%
“…Silk fibroins can be hydrolyzed by enzymes or acids, and silk fibroins hydrolyzed with a mixture of proteinases were reported to have anti-hyperglycemic activity in diabetic experimental animals [17]. However, the process is expensive and complicated, and thus, we considered that acid hydrolyzed silk fibroins might have similar anti-diabetic activities.…”
Section: Discussionmentioning
confidence: 99%