Improving image-guided target localization through deformable registration

Brock, Kristy K.; Hawkins, M.; Eccles, C.; Moseley, Joanne; Moseley, Douglas; Jaffray, David A.; Dawson, Laura A.

doi:10.1080/02841860802256491

Cited by 49 publications

(47 citation statements)

References 25 publications

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“…These have been shown to displace the stomach and bowel by ≥2cm, with low complication rates 58 . The clinical implementation of deformable image registration has the potential to improve set-up accuracy in the face of organ deformation, which leads to discrepancies in planned versus delivered doses 59 . It may also have a role in CT and MRI co-registration prior to contouring, and in comparing pre-and post-treatment imaging 59 .…”

Section: Future Technical Developmentsmentioning

confidence: 99%

“…The clinical implementation of deformable image registration has the potential to improve set-up accuracy in the face of organ deformation, which leads to discrepancies in planned versus delivered doses 59 . It may also have a role in CT and MRI co-registration prior to contouring, and in comparing pre-and post-treatment imaging 59 . The implementation of daily online image guidance using MRI in the context of the MRlinac will provide enhanced soft tissue information compared to CBCT, thus improving set-up accuracy, without the need for fiducials.…”

Section: Future Technical Developmentsmentioning

confidence: 99%

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Advances in Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma

Murray

Dawson

2017

Seminars in Radiation Oncology

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SBRT is an emerging effective treatment for hepatocellular carcinoma (HCC) associated with acceptable rates of toxicity in appropriately selected patients. Despite often being reserved for patients unsuitable for other local treatments, prospective and retrospective studies have demonstrated excellent long-term control. SBRT may be used as a stand-alone treatment, or as an adjunct to other HCC therapies. Based on available data, SBRT appears to complement existing local liver therapies.Randomised and non-randomized comparative studies are required to better determine the optimal role of SBRT in HCC treatment.

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Section: Future Technical Developmentsmentioning

confidence: 99%

Section: Future Technical Developmentsmentioning

confidence: 99%

Advances in Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma

Murray

Dawson

2017

Seminars in Radiation Oncology

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“…As regards the methodology for studying motion and deformation, different modalities have been reported, including ultrasound (17), magnetic resonance imaging (MRI) scans (18,19), repeated CT scans and on-board imaging (OBI) (15). CBCT is increasingly used for online set-up correction, soft tissue targeting, safety margin calculation (20,21) and image-guided adaptive radiotherapy (22,23). CBCT is more convenient for daily imaging compared with MRI and CT.…”

Section: Discussionmentioning

confidence: 99%

An assessment of interfractional bladder, rectum and vagina motion in postoperative cervical cancer based on daily cone-beam computed tomography

Wang

et al. 2015

Molecular and Clinical Oncology

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Abstract. Interfractional variations of the bladder, rectum and vagina may affect the accuracy of postoperative intensity-modulated radiotherapy in patients with cervical cancer. This study aimed to assess the interfractional variations with daily kV cone-beam computed tomography (CBCT). All the patients were instructed to control the filling status of the bladder and rectum. CBCT images were obtained daily after set-up and the bladder, rectum and vagina were contoured on each CBCT scan. All the contours were transferred to the planning CT following image fusion. Interfractional variations in pelvic organs were assessed with CBCT based on two reference lines, which were identified as A (the midsaggital line across the superior border of pubic symphysis) and B (a parallel line 1.5 cm above line A). The mean volume (range) of the bladder and rectum was 156.5 (1.7-626.5) and 48.2 (11.3-139.7) ml, respectively. The uniform planning target volume (PTV) margin of 10 mm failed to encompass the vagina in 17.3 and 18.1% of the fractions on lines A and B, respectively. The motion of the vagina (standard deviation) was 0.3 (0.3) and 0.1 (0.5) cm on lines A and B, respectively. The anteroposterior dimension and position of the vagina were significantly affected by the filling status of the bladder (P<0.05), but not by that of the rectum. Although instructions were given, the interfractional variations of the vagina and other pelvic organs were significant, which may exceed the uniform PTV margin; therefore, more effective methods to decrease these variations should be investigated.

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“…One of the current limitations is that this approach can only correct for rigid-body set-up errors in the patient's position 4,5 . Non-rigid deformations to patient pose are encountered frequently in external-beam radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

“…Non-rigid deformations to patient pose are encountered frequently in external-beam radiotherapy. External variations in patient geometry and incorrectly positioned appendages cannot be corrected by rigid-body adjustments alone and may distort the internal anatomy of the patient 4 . This may alter the treatment volume and decrease the overall quality of treatment.…”

Section: Introductionmentioning

confidence: 99%

A method for patient set-up guidance in radiotherapy using augmented reality

Talbot

Meyer

Watts

et al. 2009

Australas. Phys. Eng. Sci. Med.

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A system for patient set-up in external beam radiotherapy was developed using Augmented Reality (AR). Live images of the linac treatment couch and patient were obtained with video cameras and displayed on a nearby monitor. A 3D model of the patient's external contour was obtained from planning CT data, and AR tracking software was used to superimpose the model onto the video images in the correct position for treatment. Throughout set-up and treatment, the user can view the monitor and visually confirm that the patient is positioned correctly. To ensure that the virtual contour was displayed in the correct position, a process was devised to register the coordinates of the linac with the camera images. A cube with AR tracking markers attached to its faces was constructed for alignment with the isocentre using room lasers or cone-beam CT. The performance of the system was investigated in a clinical environment by using it to position an anthropomorphic phantom without the aid of additional set-up methods. The positioning errors were determined by means of CBCT and image registration. The translational set-up errors were found to be less than 2.4 mm and the rotational errors less than 0.3 degrees. This proof-of-principle study has demonstrated the feasibility of using AR for patient position and pose guidance.

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Improving image-guided target localization through deformable registration

Cited by 49 publications

References 25 publications

Advances in Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma

Advances in Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma

An assessment of interfractional bladder, rectum and vagina motion in postoperative cervical cancer based on daily cone-beam computed tomography

A method for patient set-up guidance in radiotherapy using augmented reality

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