Improving image segmentation performance and quantitative analysis via a computer-aided grading methodology for optical coherence tomography retinal image analysis

DeBuc, Delia Cabrera; Salinas, Harry M.; Ranganathan, Sudarshan; Tátrai, Erika; Gao, Wensheng; Shen, Meixiao; Wang, Jianhua; Somfai, Gábor Márk; Puliafito, Carmen A.

doi:10.1117/1.3470116

Cited by 20 publications

(15 citation statements)

References 30 publications

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“…Sull et al compared TRT in ETDRS partitions obtained with several commercial devices and found the results obtained with SD-OCT to be similar 21. Our results of TRT were within the ranges, compared to the results reported by others 21,25. The thickness maps for six intraretinal layers obtained in the present study in EDTRS sections were also similar to those reported in a previous study,22 with some mild disparities.…”

Section: Discussionsupporting

confidence: 90%

“…These findings may possibly be because the ONL in the present study included ONL and IS, and PR might include the outer segment of photoreceptors. The thickness values of OPL layer in ETDRS sectors were lower than those in other studies,22,25,37,39 but similar to the value reported by Liu et al35 Since the OCT used in the present study and by Liu et al are both custom-built systems with similar hardware configuration, similar results from healthy subjects may be expected. The remaining differences between the present study and other previous reports may also be simply due to the variation across normal subjects, imaging resolution, and algorithm differences.…”

Section: Discussionsupporting

confidence: 89%

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The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects

Tan¹,

Ye²,

Jiang³

et al. 2016

OPTH

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PurposeTo determine the repeatability and profiles with different partition methods in intraretinal thickness layers in healthy human subjects, using optical coherence tomography (OCT).MethodsA custom-built ultrahigh-resolution OCT was used to acquire three-dimensional volume of the macula in 20 healthy subjects. The dataset was acquired twice using the macular cube 512×128 protocol in an area of 6×6 mm2 centered on the fovea. Commercially available segmentation software (Orion™) was used to segment the dataset into thickness maps of six intraretinal layers. The coefficient of repeatability and intraclass coefficient of correlation (ICC) were analyzed using hemispheric zoning and sectors defined by the Early Treatment Diabetic Retinopathy Study (ETDRS).ResultsAll datasets were successfully segmented to create six thickness maps of individual intraretinal layers. Coefficients of repeatabilities of these layers in hemispheric zones ranged from 0.9 to 6.6 µm, with an average of 3.6 µm (standard deviation [SD] 1.4), which was not significantly different compared to ETDRS sectors (P>0.05). ICCs of these layers in hemispheric zones ranged from 0.68 to 0.99, with an average of 0.91 (SD 0.07). There were no significant differences in ICCs between two zoning methods (P>0.05). Significant variations of tomographic intraretinal thicknesses were found between the inner and outer annuli and among the quadrantal sectors within the inner and outer annuli (P<0.05). Significant variations of the quadrantal sectors including both inner and outer annuli were evident in intraretinal layers (P<0.05) except for the outer plexiform layer.ConclusionThe measurement repeatabilities of tomographic thicknesses of intraretinal layers are comparable using both hemispheric and ETDRS partitions in volumetric data combined with the commercially available segmentation software. In keeping with known, normal anatomical variation, significant differences in tomographic thickness in various intraretinal layers were apparent in both hemispheric and ETDRS sectors.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects

Tan¹,

Ye²,

Jiang³

et al. 2016

OPTH

Self Cite

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“…The OCTRIMA software enables the segmentation of 6 layers of the retina on OCT images based on their optical densities: the RNFL, the GCL+IPL complex, the inner nuclear layer (INL), the outer plexiform layer (OPL), the outer nuclear layer (ONL) and retinal pigment epithelium (RPE). We have previously shown the high repeatability and reproducibility of OCTRIMA measurements in normal subjects with undisrupted retinal structure similarly to what is observed in patients with MS [20], [21]. The reproducibility was the highest for the thickness measurements of the ONL, GCC, GCL+IPL and RNFL, the inter- and intraexaminer, intervisit variabilities (<6 µm for all layers and all comparisons) being under the resolution of the Stratus OCT device for all layers [21].…”

Section: Methodssupporting

confidence: 69%

In Vivo Evaluation of Retinal Neurodegeneration in Patients with Multiple Sclerosis

et al. 2012

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ObjectiveTo evaluate macular morphology in the eyes of patients with multiple sclerosis (MS) with or without optic neuritis (ON) in previous history.MethodsOptical coherence tomography (OCT) examination was performed in thirty-nine patients with MS and in thirty-three healthy subjects. The raw macular OCT data were processed using OCTRIMA software. The circumpapillary retinal nerve fiber layer (RNFL) thickness and the weighted mean thickness of the total retina and 6 intraretinal layers were obtained for each eye. The eyes of MS patients were divided into a group of 39 ON-affected eyes, and into a group of 34 eyes with no history of ON for the statistical analyses. Receiver operating characteristic (ROC) curves were constructed to determine which parameter can discriminate best between the non-affected group and controls.ResultsThe circumpapillary RNFL thickness was significantly decreased in the non-affected eyes compared to controls group only in the temporal quadrant (p = 0.001) while it was decreased in the affected eyes of the MS patients in all quadrants compared to the non-affected eyes (p<0.05 in each comparison). The thickness of the total retina, RNFL, ganglion cell layer and inner plexiform layer complex (GCL+IPL) and ganglion cell complex (GCC, comprising the RNFL and GCL+IPL) in the macula was significantly decreased in the non-affected eyes compared to controls (p<0.05 for each comparison) and in the ON-affected eyes compared to the non-affected eyes (p<0.001 for each comparison). The largest area under the ROC curve (0.892) was obtained for the weighted mean thickness of the GCC. The EDSS score showed the strongest correlation with the GCL+IPL and GCC thickness (p = 0.007, r = 0.43 for both variables).ConclusionsThinning of the inner retinal layers is present in eyes of MS patients regardless of previous ON. Macular OCT image segmentation might provide a better insight into the pathology of neuronal loss and could therefore play an important role in the diagnosis and follow-up of patients with MS.

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“…Manual correction of the boundary detection is enabled if segmentation errors are present. The repeatability and reproducibility of the thickness measurements was assessed earlier and was found to be very good [35], [36]. All the scans were segmented by the same blinded operator to reduce the possible bias caused by different operators and unblinded analysis.…”

Section: Methodsmentioning

confidence: 99%

A Morphological Study of Retinal Changes in Unilateral Amblyopia Using Optical Coherence Tomography Image Segmentation

et al. 2014

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ObjectiveThe purpose of this study was to evaluate the possible structural changes of the macula in patients with unilateral amblyopia using optical coherence tomography (OCT) image segmentation.Patients and Methods38 consecutive patients (16 male; mean age 32.4±17.6 years; range 6–67 years) with unilateral amblyopia were involved in this study. OCT examinations were performed with a time-domain OCT device, and a custom-built OCT image analysis software (OCTRIMA) was used for OCT image segmentation. The axial length (AL) was measured by a LenStar LS 900 device. Macular layer thickness, AL and manifest spherical equivalent refraction (MRSE) of the amblyopic eye were compared to that of the fellow eye. We studied if the type of amblyopia (strabismus without anisometropia, anisometropia without strabismus, strabismus with anisometropia) had any influence on macular layer thickness values.ResultsThere was significant difference between the amblyopic and fellow eyes in MRSE and AL in all subgroups. Comparing the amblyopic and fellow eyes, we found a statistically significant difference only in the thickness of the outer nuclear layer in the central region using linear mixed model analysis keeping AL and age under control (p = 0.032). There was no significant difference in interocular difference in the thickness of any macular layers between the subgroups with one-way between-groups ANCOVA while statistically controlling for interocular difference in AL and age.ConclusionsAccording to our results there are subtle changes in amblyopic eyes affecting the outer nuclear layer of the fovea suggesting the possible involvement of the photoreceptors. However, further studies are warranted to support this hypothesis.

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Improving image segmentation performance and quantitative analysis via a computer-aided grading methodology for optical coherence tomography retinal image analysis

Cited by 20 publications

References 30 publications

The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects

The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects

In Vivo Evaluation of Retinal Neurodegeneration in Patients with Multiple Sclerosis

A Morphological Study of Retinal Changes in Unilateral Amblyopia Using Optical Coherence Tomography Image Segmentation

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