In order to solve the problem of more and more vicious events caused by college students“ mental ill-health, a research method of health education knowledge service information system model based on virtual reality is proposed. The platform development approach is based on virtual reality to provide technical support to the process of acquiring, maintaining, pushing, applying, and updating the knowledge of mental health education for college students. The system includes a knowledge base for storing college students’ mental health education knowledge, tools for supporting acquisition, classification, editing, and storage of knowledge, and tools for knowledge sharing, application, and innovation of teachers and experts engaged in college students’ mental health education. The results are as follows: after using this system, the proportion of students with excellent mental health status in a university has increased significantly, reaching 75%, and the proportion of students with poor health status has decreased from 15% to 7%. The mental health knowledge sharing platform designed in this paper has obtained satisfactory evaluation in the trial universities, accounting for 68% of the trial population. The system presented in this article demonstrates that the system can significantly improve the mental health of college students, and the system outlined in this document is important for improving the efficiency and quality of mental health education for college students and for effectively managing educational knowledge.