This Special Issue of the journal Water, “The Evaluation of Hydrologic Response to Climate Change”, is intended to explore the various impacts of climate change on hydrology. Using a selection of approaches, including field observations and hydrological modeling; investigations, including changing habitats and influences on organisms; modeling of water supply and impacts on landscapes; and the response of varying components of the hydrological cycle, the Issue has published nine articles from multi-institution, often multicountry collaborations that assess these changes in locations around the world, including China, Korea, Russia, Pakistan, Cambodia, United Kingdom, and Brazil.