Improving posttransplantation survival of human ovarian tissue by treating the host and graft

Abir, Ronit; Fisch, Benjamin; Jessel, Shlomit; Felz, Carmela; Ben-Haroush, Avi; Orvieto, Raoul

doi:10.1016/j.fertnstert.2010.07.1082

Cited by 76 publications

(100 citation statements)

References 35 publications

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“…The HMG was used 4 weeks after transplantation, missing the critical time that induced neovascularization and therefore caused fibrosis, which also indicated the importance of using angiogenic factor at the early stage of neovascularization. However, Abir et al [31] did not observe the improvement of the primordial or growing follicles survival rate in the grafts when started gonadotrophin administration 2-days before and 2 days after grafting, compared with untreated recipients. They suggested that additional exogenous gonadotropin administration is probably unnecessary.…”

Section: Discussionmentioning

confidence: 92%

“…The administration of angiogenic factors has been used in ovarian transplantation animal models [27,31]. According to previous data, the increased VEGF expression in the grafted ovaries appeared 2 days after transplantation [32], which is also the critical time that the total follicle pool was reduced and the area of the grafted tissue was non-reversibly damaged.…”

Section: Discussionmentioning

confidence: 98%

“…Although the patients we chose were young, we even found no follicle in some fresh control samples unexpectedly. Follicles are distributed unevenly in human ovary, and we might have inadvertently transplanted slices with no or only few follicles [31]. However, on analysis of the results from an endometrial cancer patient (Patient 2), a high number of follicles were identified in the transplanted samples in group C, most of which were primordial follicles.…”

Section: Discussionmentioning

confidence: 99%

“…Although the administration of VEGF and bFGF showed their potential to improve graft and follicular survival in animals, we still need to consider the risk of side effect of those angiogenic factors [31] if the results need to be eventually applied to human autotransplantation. Based on Lund et al [34] experience with in vivo bFGF and VEGF expression levels in tumor xenografts, bFGF doses higher than 1,000 ng and VEGF higher than 200 ng per chamber were considered unphysiological and therefore irrelevant.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

VEGF and bFGF increase survival of xenografted human ovarian tissue in an experimental rabbit model

Wang

Ying

OuYang

et al. 2013

J Assist Reprod Genet

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

VEGF and bFGF increase survival of xenografted human ovarian tissue in an experimental rabbit model

Wang

Ying

OuYang

et al. 2013

J Assist Reprod Genet

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“…In this controlled study, it is noteworthy that untreated xenografted animals showed a normal uterine development, whereas those xenografted and treated with gonadotropins, triptorelin, or both, showed underdevelopment [78]. Other substances such as the anti-apoptotic S1P and angiogenic factors, such as VEGF, are currently under scrutiny to establish if they could improve the immediate post-transplant follicular loss [87][88][89].…”

Section: Ovarian Cortical Tissue Transplantmentioning

confidence: 92%

Applicability of adult techniques for ovarian preservation to childhood cancer patients

Detti

Williams

2012

J Assist Reprod Genet

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Purpose To appraise the feasibility of current adult medical and surgical techniques for ovarian preservation in prepubertal and adolescent girls with cancer. Methods Literature search using PubMed and SCOPUS up to February 2012. In addition, the reference lists of selected studies and all identified systematic and narrative reviews were scanned for relevant references. Inclusion criteria were ovarian preservation and cancer. Exclusion criteria were non-English publications, letters, personal communications, and ovarian preservation for conditions other than cancer. Results Data from the selected publications was interpreted and discussed in the relevant sections. Cryopreservation of ovarian tissue followed by autologous transplant represents the only surgical option available for pre-pubertal girls and adolescents who cannot delay the start of chemotherapy. Few studies report on pre-pubertal and adolescent girls undergoing ovarian preservation surgeries with good harvesting, and no follow-up has been conveyed, to date. Outcomes of ovarian function after ovarian suppression with GnRH-analogs in adults have been controversial and no reports are available for pre-pubertal girls. Conclusions Autologous transplantation of cryopreserved ovarian cortex probably represents the best option for preservation of fertility and hormonal function in childhood cancer females; however, future research needs to address the safety of this technique, especially in patients with blood-borne cancers. Ovarian suppression with GnRHanalogs at the time of chemotherapy treatment has not proven to be superior to non-suppression for fertility preservation purposes in adults. Not enough evidence is presently available in childhood cancer patients.

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Assessment of the effect of different vitrification solutions on human ovarian tissue after short‐term xenotransplantation onto the chick embryo chorioallantoic membrane

Zeng

Tang

Zeng

et al. 2016

Molecular Reproduction Devel

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Chemotherapy can lead to the loss of fertility and premature ovarian failure in young women who suffer from malignant diseases. Freezing ovarian tissue by vitrification allows for the preservation of a large number of follicles prior to treatment, yet no established protocols have been optimized with respect to the vitrification solution. The aim of the present study was to evaluate the early stage of human ovarian tissue xenotransplantated onto the chick embryo chorioallantoic membrane after vitrification, and to determine the effect of different vitrification solutions on ovarian tissue quality-as defined by morphology and viability of follicles, neovascularization, cell proliferation, and apoptosis. Each vitrification protocol had a different impact on ovarian tissue at the early transplantation stage; one process using the lowest concentrations of ethylene glycol and dimethylsulfoxide, plus sucrose, demonstrated a moderate advantage compared to the other protocols. We also demonstrated that the chorioallantoic membrane model can be a useful alternative for short-term xenotransplantation studies of angiogenesis into human ovarian cortical tissue.

show abstract

Improving posttransplantation survival of human ovarian tissue by treating the host and graft

Cited by 76 publications

References 35 publications

VEGF and bFGF increase survival of xenografted human ovarian tissue in an experimental rabbit model

VEGF and bFGF increase survival of xenografted human ovarian tissue in an experimental rabbit model

Applicability of adult techniques for ovarian preservation to childhood cancer patients

Assessment of the effect of different vitrification solutions on human ovarian tissue after short‐term xenotransplantation onto the chick embryo chorioallantoic membrane

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