Improving Provision of Care for Long-term Survivors of Lymphoma

Ciavarella, Sabino; Minoia, Carla; Quinto, Angela Maria; Oliva, Stefano; Carbonara, Santa; Cormio, Claudia; Cox, Maria Christina; Bravo, Elena; Santoro, Filippo; Napolitano, Mariarosaria; Spina, Michele; Loseto, Giacomo; Giacosa, Attilio

doi:10.1016/j.clml.2017.08.097

Cited by 22 publications

(27 citation statements)

References 68 publications

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“…Cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) is one of the most widely used protocols and has an overall response rate (ORR) of 85%. Other regimens well tolerated by the elderly with comorbidities are: cyclophosphamide, vincristine and prednisone (CVP); oral etoposide, gemcitabine and methotrexate at low doses or in monotherapy [43][44][45]. All these regimens are valid therapeutic options in this subset of patients, although they have shown a high frequency of relapses.…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in Elderly, the Importance of a Sport Activity Training

Sica¹,

Vitiello²,

Ronchi³

et al. 2019

Preprint

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： PcALCL mainly concerns elderly patients. It is a large CD30+ T-cell neoplasm composed of large cells with anaplastic, pleomorphic or immunoblastic morphology, with exclusively cutaneous onset and localization. The clinical course of pcALCL is predominantly indolent. Most elderly patients with lymphoma tend to have a sedentary lifestyle, which has a negative effect on their quality of life (QoL) and on their survival. Several studies indicate that exercise has a positive impact on QoL because it reduces peak oxygen consumption, improves physical capacity, increases self-esteem, reduces accumulated stress and promotes relaxation. Therefore, particularly in indolent lymphomas, it is necessary to indicate a program of physical activity to be practiced systematically. The complete surgical excision and local radiotherapy are the first line gold standard in pcALCL with solitary lesion.

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Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in Elderly, the Importance of a Sport Activity Training

Sica¹,

Vitiello²,

Ronchi³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…The type of program is different from a patient to another. The preliminary evaluation is multidimensional and should include general clinical conditions, functional state of different organs, psychic state, physical-motor capacity (strength, flexibility, muscular coordination), cardiovascular function under stress conditions, comorbidities and social conditions [37]. Each of these points is very important for a correct adherence to a rehabilitation program [38].…”

Section: Introductionmentioning

confidence: 99%

Post-Transplant Lymphoproliferative Diseases in an Elderly Population Who Underwent Cardiac Transplantation: Role of Physical Activity Rehabilitation Program

Sica¹,

Sagnelli²,

Fasano³

et al. 2019

Preprint

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The incidence of post transplantation lymphoproliferative disorders (PTLDs) and other neoplasms in organ transplant patients is higher than in the non-transplanted population. This event is more frequent in older subjects, due, at least in part, to the immune dysfunction induced by immunosuppressants administered to prevent rejection. Alterations of the immune system mechanisms of protection against carcinogenesis appear to be the key role in the in the pathogenesis of these neoplasms.The data of our study on the incidence of neoplasms occurred during a long-term follow-up in an elderly population after they underwent cardiac transplantation. This study gives, also evidence of the favorable effect of physical activity programs on cardiorespiratory and psychomotor function.

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“…Programs vary from a patient to another and consequently, several parameters should be evaluated: the functional state of the various organs, the 4 psychic conditions, the physical-motor skills (strength, flexibility, muscle coordination), the cardiovascular function in stressful conditions, the comorbidities, the associated drug therapy, the social conditions, the habits and feeding capacity [40][41]. All this fundamental in order to organize a network that the patient can constantly follow [42][43][44][45]. Programs include aerobic exercise to increase muscle endurance, exercises to strengthen the extensor muscles of the legs and the upper limbs, useful for doing household chores and other activities of the daily life [46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Post-Transplant Lymphoproliferative Diseases in the Elderly after Cardiac Transplantation: The Diagnostic Role of [18f] FDG-PET With Co-Registered CT and the Effect of Sports Activity Rehabilitation Program

Sica¹,

Rimini²,

Casale³

et al. 2019

Preprint

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The incidence of cancer in organ transplant patients is higher than in the non-transplanted population. The incidence increases with increasing age. The use of Fludeoxyglucose positron emission tomography/CT (PET/CT) is sensitive and specific to detect PTLD LD compared with conventional CT imaging. We analyzed the medical data of 127 patients aged over 60 years, who underwent heart transplantation in the above period, who have been practicing early CT-PET for diagnostic purposes between February 2007 and October 2018. Of 127 consecutive patients who underwent CT-PET, SUVs up than 4, were found in 84 patients of which 20 were affected by PTLDs, seven patients were affected by chronic non neoplastic inflammatory diseases, the remainder were affected by other neoplasms. The favorable effect of physical activity programs on cardiorespiratory and psychomotor function occur in all patients. In conclusion, CT-PET at the first doubts about the possibility of the development of neoplasms has allowed a diagnosis and then a treatment more quickly. Education in behavioral norms that improve the patient's quality of life is necessary.

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Improving Provision of Care for Long-term Survivors of Lymphoma

Cited by 22 publications

References 68 publications

Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in Elderly, the Importance of a Sport Activity Training

Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in Elderly, the Importance of a Sport Activity Training

Post-Transplant Lymphoproliferative Diseases in an Elderly Population Who Underwent Cardiac Transplantation: Role of Physical Activity Rehabilitation Program

Post-Transplant Lymphoproliferative Diseases in the Elderly after Cardiac Transplantation: The Diagnostic Role of [18f] FDG-PET With Co-Registered CT and the Effect of Sports Activity Rehabilitation Program

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