The visualization of arteries and heart usually plays a crucial role in the clinical diagnosis, but researchers face the problem of region selection and mutual occlusion in clinical visualization. So the arteries and heart cannot be easily visualized by the current methods of visualization. To solve these problems, we propose a new framework for arteries and cardiac visualization by combining the priori knowledge and set operations. Firstly, a suitable region can be easily determined in transfer function space with the priori knowledge and visual feedback results. Secondly, the arteries and heart can be directly extracted by the marked seed point. Finally, the arteries and heart are separated for solving mutual occlusion through set operations. This framework can easily solve the mutual occlusion problem in clinical visualization and greatly improve the region selection method in transfer function space. Its effectiveness has been demonstrated on the basis of many experimental results when compared with visualization results of clinical medical workstations in real-world 3D computed tomography angiography (CTA) images.