2015
DOI: 10.1111/wrr.12284
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Improving the ability to eliminate wounds and pressure ulcers

Abstract: Pressure ulcers can be initiated by as little as 2 hours of constant pressure on the ski, that blocks blood circulation causing the skin and underlying tissues to die, leading to an open wound that never heals, but continues to grow in diameter and depth, and frequently jeopardizes patients' lives. Despite the application of many diverse techniques, pressure ulcers remain exceptionally difficult to heal because many ulcer elimination techniques have minimal effects, and although other techniques may appear to … Show more

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Cited by 15 publications
(13 citation statements)
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“…With treatment in specialized wound centers in Germany these costs rise to £9,569 per patient (Purwins et al, 2010 ). One in five in-patients in European hospitals have a pressure ulcer (Martin-Granados and McCaig, 2014 )—which are open wounds that are exceptionally difficult to heal, often progressing to become life-threatening (Kuffler, 2015 ). Moreover, in spite of medical interventions there is a rising prevalence of such wounds, associated with the increasing incidence of diabetes mellitus, and an increasingly aging population (Fonder et al, 2008 ), with 15% of diabetic foot ulcers resulting in amputation (Posnett and Franks, 2008 ), or an amputation each 30 s worldwide (Richard and Schuldiner, 2008 ), which in turn leads to over 50% mortality within 5 years (Reiber et al, 1995 ).…”
Section: Introductionmentioning
confidence: 99%
“…With treatment in specialized wound centers in Germany these costs rise to £9,569 per patient (Purwins et al, 2010 ). One in five in-patients in European hospitals have a pressure ulcer (Martin-Granados and McCaig, 2014 )—which are open wounds that are exceptionally difficult to heal, often progressing to become life-threatening (Kuffler, 2015 ). Moreover, in spite of medical interventions there is a rising prevalence of such wounds, associated with the increasing incidence of diabetes mellitus, and an increasingly aging population (Fonder et al, 2008 ), with 15% of diabetic foot ulcers resulting in amputation (Posnett and Franks, 2008 ), or an amputation each 30 s worldwide (Richard and Schuldiner, 2008 ), which in turn leads to over 50% mortality within 5 years (Reiber et al, 1995 ).…”
Section: Introductionmentioning
confidence: 99%
“…Our previous study demonstrates that UVB irradiation results in ROS accumulation and extracellular signal-regulated kinases (ERKs) activation, which causes the nuclear p53 accumulation and thrombomodulin (TM) promoter binding to inhibit TM expression [17]. To prevent oxidative deterioration, antioxidant extracted from natural herbal sources is widely reported to be used to protect the skin from damage by limiting the production of free radicals, calming inflammation [18], and stimulating blood flow in the skin to encourage the growth of new cells [19, 20]. Nrf2 also plays an important role in protecting the skin against UV irradiation [21].…”
Section: Introductionmentioning
confidence: 99%
“…Despite the application of diverse techniques, there is little evidence supporting their efficiency. An individualised approach to wound healing technologies is regarded as a key element of several novel approaches, including hyperbaric oxygenation therapy (HBOT) [1]. Hyperbaric oxygenation therapy is perceived as a novel basic or supplementary method in wound healing.…”
Section: Introductionmentioning
confidence: 99%
“…Its application significantly increases the percentage of completely healed patients (by up to 74-100%) and minimises the number of amputations relative to traditional approaches [1].…”
mentioning
confidence: 99%
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