Improving the assessment of everyday cognitive functioning in patients with epilepsy by means of proxy reports

Karkoska, Anne; Hallmeyer-Elgner, Susanne; Berth, Hendrik; Reichmann, Heinz; Schmitz-Peiffer, Henning

doi:10.1016/j.yebeh.2014.12.005

Cited by 6 publications

(7 citation statements)

References 20 publications

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“…Attention SCI was predicted by psychomotor speed performance, and executive function SCI was independently linked to verbal fluency. We extended previous research that solely focused on bivariate, i.e., uncontrolled, correlations between attention SCI and attention measures or executive function SCI and executive function measures 16,24,25,28 . Our statistical models predicting attention and executive function SCI consisted of corresponding objective measures.…”

Section: Discussionmentioning

confidence: 99%

“…Even though difficulties in executive functions are frequently reported in PWE, 28,29 overlap with objective executive function has rarely been studied. Only single studies report bivariate correlations with test results 25,28 . Altogether, in PWE, comprehensive investigations of SCI in different cognitive domains, especially in executive functions, are still lacking.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, we investigate whether SCI in memory, attention, and executive functions is correlated with corresponding objective measures. We selected parameters that are often impaired in PWE and that showed associations with SCI previously 11,22,28,30 . Extending previous work, which often solely considered univariate correlations, 11,24,28 we control for various possible epilepsy‐related, pharmacological, social, and psychological confounders.…”

Section: Introductionmentioning

confidence: 99%

“…Whereas some univariate correlations between attention SCI and OCI have been identified, 11,24,25 other studies have demonstrated that attention complaints and scores were unrelated, especially after controlling for confounders. 26,27 Even though difficulties in executive functions are frequently reported in PWE, 28,29 overlap with objective executive function has rarely been studied. Only single studies report bivariate correlations with test results.…”

Section: Introductionmentioning

confidence: 99%

“…Only single studies report bivariate correlations with test results. 25,28 Altogether, in PWE, comprehensive investigations of SCI in different cognitive domains, especially in executive functions, are still lacking. Nevertheless, understanding which factors are linked to SCI is of great clinical relevance, as based on the relationships, tailored counseling and specific (neuro-)psychological treatment options can be offered.…”

Section: Introductionmentioning

confidence: 99%

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Domain‐specific relationships of subjective and objective cognition in epilepsy

et al. 2023

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Objective: Many people with epilepsy report subjective cognitive impairment (SCI), i.e., problems with memory, attention, or executive functions, reducing quality of life. Nevertheless, overlap with objective cognitive impairment (OCI) is often weak. One reason may be a domain-specific mismatch between subjective reports and objective tests. We aimed to evaluate relations between SCI and OCI of corresponding domains and to assess whether these differ between persons who over-or underestimate their performance. Methods:In this prospective, cross-sectional sample of 104 adult inpatients with epilepsy, we performed multiple regression analyses predicting SCI in the domains attention, memory, and executive functions. We tested relationships with measures of psychomotor speed, short-term memory, verbal learning, verbal delayed recall, and word fluency while controlling for age, sex, seizure frequency, structural lesions, mono-versus polytherapy and adverse events of antiseizure medication (ASM), depressive and anxiety symptoms, level of education, and employment status. Furthermore, we tested whether these relationships differed between realistic raters and over-and underestimators. Results:We found domain-specific relations for attention and executive functions for the full sample, explaining a small proportion of variance of SCI (general dominance index = .03 and .004), whereas ASM adverse events and psychological variables were more important predictors. When dividing the sample according to the concordance of SCI and OCI, we found high frequencies of both over-(23%-46%) and underestimation (31%-35%) depending on the domain. The explanatory power of OCI for SCI was stronger within the subgroups compared to the full sample, suggesting nonlinear relationships and different underlying mechanisms for realistic raters, underestimators, and overestimators.Significance: Domain-specific SCI and OCI are related, and both should be assessed with standardized instruments. These relationships differ between overand underestimators as well as realistic raters. Based on the concordance of

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%