Improving the granule strength of roller-compacted ibuprofen sodium for hot-melt coating processing

Lopes, Diogo Gomes; Garsuch, Verena; Becker, Karin; Paudel, Amrit; Stehr, Michael; Zimmer, Andreas; Salar-Behzadi, Sharareh

doi:10.1016/j.ijpharm.2016.06.049

Cited by 12 publications

(8 citation statements)

References 28 publications

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“…Dry granulation technology via roller compaction (RC) is increasingly applied in the pharmaceutical industry to produce solid oral dosage forms, mainly tablets, as well as capsules and sachets (Chang et al, 2008, Lopes et al, 2016). The granulation step primarily addresses the poor flowability of powders and other issues, such as dustiness, low bulk density and propensity for segregation.…”

Section: Introductionmentioning

confidence: 99%

Model-based approach to the design of pharmaceutical roller-compaction processes

Toson

Lopes

Paus

et al. 2019

International Journal of Pharmaceutics: X

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Section: Introductionmentioning

confidence: 99%

Model-based approach to the design of pharmaceutical roller-compaction processes

Toson

Lopes

Paus

et al. 2019

International Journal of Pharmaceutics: X

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“…The meltable materials can be added to the starting powder mixture can be in the form of either solid particles or molten liquid 37 . Accordingly the procedure of the process basically is ether melt-in procedure or spray-on procedure 38 . Solid meltable binder melts during the process termed as melt-in procedure 2,34 .…”

Section: Hmc Using Fluid-bed Processormentioning

confidence: 99%

Dry-Coating of Powder Particles is Current Trend in Pharmaceutical Field

Alli¹

2021

J. Drug Delivery Ther.

608

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Modification of surface attributes of particles, usually accomplished by coating, is desirous to enhance and maintain their usability. Coating is a multi-step process involves application of the coating material (CoM) onto the substrate, herein powder particles, where the process along with device/ equipment monitors surface attributes of the applied coating. Nowadays competitive market calls for cost cutting to survive product(s). Thus saving of energy and time, minimising number and quantity of additives, reducing and shortening process steps; consequently minimising the coating process cost are main goals while developing coating process for powder particle. Innovation of processes for dry-powder coating (DPC) along with their further development and refinement finds solution to said issues. Further, DPC process does not calls for liquid solvent or solution thus are viewed as cost-effective and environmentally safe, DPC process uses thermo-mechanical methods like mechanofusion, magnetic assisted impaction coating (MAIC), hybridization, rotating fluid-bed process, theta-composer, hot-melt coating (HMC), and many others. Besides these available are non-thermo-mechanical methods namely electrostatic coating; supercritical fluids (SCF) based methods like rapid expansion of supercritical fluid (RESF), gas anti-solvent (GAS), SCF anti-solvent, gas-saturated solution (GSS); vapour coating; and others. Basing on said thermo-mechanical and non-thermo-mechanical principle several DPC methods/ process had been reported in scientific literatures and patents. Said DPC method founds multidisciplinary applications like drug delivery and drug development. Diverse devices are there for the DPC process; their method of working, principle, limitations and benefits along with their applicability in pharmaceutical field are discussed and presented in this article. Keywords: Dry, particle, coating, pharmaceutical, process

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“…Moreover, the addition of polysorbate 65 maintained the immediate release profile of the water-soluble drug as well. Both in vivo and in vitro results showed that the coating amount, emulsifier content, and spray pressure were the main critical parameters (68,69).…”

Section: Coating With Lipidsmentioning

confidence: 99%

Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems

et al. 2019

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Particle engineering has become a hot topic in the field of modified-release delivery systems during last decades. It has a wide range of pharmaceutical applications and is a bridge linking between drugs and drug delivery systems. Particles are an important part of many dosage forms and viewed as a carrier of drugs. Their size, shape, crystalline form, and structure directly affect the stability and releasing pattern of drugs. Engineering size or modifying particles by forming porous, core-shell, or skeleton structures can realize the development and utilization of functionally modified release systems (including fast-release systems, sustained-release systems, and targeted-release systems). However, there are certain problems in the practical application, such as bitter taste and coating damage. Combining with some polymer or lipid materials to form core-shell or embedded structures is considered as the key to taste masking. And, using cushioning agents is proven to be effective in preserving the integrity of the functional coating film of multiparticulates during tableting. To sum up, this review, from a particle engineering point, expounds the influence of different factors on the functionality of particles and offers some useful comments and suggestions for industry personnel.

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Improving the granule strength of roller-compacted ibuprofen sodium for hot-melt coating processing

Cited by 12 publications

References 28 publications

Model-based approach to the design of pharmaceutical roller-compaction processes

Model-based approach to the design of pharmaceutical roller-compaction processes

Dry-Coating of Powder Particles is Current Trend in Pharmaceutical Field

Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems

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